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The FIRST LEGO League Challenge is an international competition organized by FIRST for elementary and middle school students.

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Body Forward is the 2010-11 FIRST Lego League competition. The project and missions revolve around biomedical engineering.

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Food Factor is the FIRST Lego League (FLL) competition for 2011-12; released on September 2. It focuses on food safety and methods to prevent contamination.

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Hydro Dynamics is the name of the 2017/18 FIRST Lego League challenge. It focuses on the water cycle and the ways in which humans can influence it. Each event consists of two main portions: the project and robot gameplay. Teams have fewer than ten weeks to prepare for their competitions.

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Nano Quest was the name of the 2006–07 challenge theme of FIRST Lego League. It revolved around the emerging field of nanotechnology.

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No Limits is the 2004-05 FIRST Lego League challenge theme. It focused on solutions for aiding people with physical disabilities. The year's theme was introduced by the story Late for Lunch by James Patrick Kelly, which the described the life of a disabled child.

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Ocean Odyssey is the 2005-06 FIRST Lego League challenge theme. It centered on topics relating to the world's oceans and oceanography. The challenge was developed with the collaboration of the Woods Hole Oceanographic Institution and the Monterey Bay Aquarium Research Institute.

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Smart Move is the name of the 2009-10 FIRST Lego League challenge, released September 3, 2009. It is centered on transport and how to make new and more efficient forms.