
The Minister of Health, Welfare and Sport is the head of the Ministry of Health, Welfare and Sport and a member of the Cabinet and the Council of Ministers. The current Minister of Health, Welfare and Sport is Hugo de Jonge of the Christian Democratic Appeal who has been in office since 26 October 2017 and also serves as First Deputy Prime Minister. The Minister of Health, Welfare and Sport is often assigned a State Secretary who is tasked with specific portfolios. The current State Secretary for Health, Welfare and Sport is Paul Blokhuis of the Christian Union (CU) who has been in office since 26 October 2017. Additionally there is also a Minister without Portfolio assigned to the Ministry of Health, Welfare and Sport, Tamara van Ark of the People's Party for Freedom and Democracy (VVD) who has been in office since 9 July 2020.

Hedwig "Hedy" d'Ancona is a retired Dutch politician of the Labour Party (PvdA) and political activist.

Louis Joseph Maria Beel was a Dutch politician of the defunct Roman Catholic State Party (RKSP) and later co-founder of the Catholic People's Party (KVP) now the Christian Democratic Appeal (CDA) party and jurist who served as Prime Minister of the Netherlands from 3 July 1946 until 7 August 1948 and from 22 December 1958 until 19 May 1959.

Eduard Jan Bomhoff is a Dutch economist. He served as Deputy Prime Minister and Minister of Health, Welfare and Sport for the Pim Fortuyn List (LPF) in the Cabinet Balkenende I from 22 July 2002 until 16 October 2002.

Else "Els" Borst-Eilers was a Dutch politician of the Democrats 66 (D66) party and physician. She was granted the honorary title of Minister of State on 21 December 2012.

Leendert Cornelis "Elco" Brinkman is a retired Dutch politician of the Christian Democratic Appeal (CDA) party and businessperson.

Mathilde Hubertine Maria Francisca "Til" Gardeniers-Berendsen was a Dutch politician of the defunct Catholic People's Party (KVP) and later the Christian Democratic Appeal (CDA) party and nonprofit director.

Aart Jan de Geus is a retired Dutch politician of the Christian Democratic Appeal (CDA) party and businessman. He served as Minister of Labor and Social Affairs from 2002 to 2007. Then he worked as Deputy Secretary-General for the OECD. From 2012 to 2019, De Geus was Chairman and CEO of the Bertelsmann Stiftung. Since January 2020, he has been Chairman of the Goldschmeding Foundation.

Leendert Ginjaar was a Dutch politician of the People's Party for Freedom and Democracy (VVD) and chemist.

Johannes Franciscus "Hans" Hoogervorst is a retired Dutch politician of the People's Party for Freedom and Democracy (VVD) and economist. He is the chairman of the International Accounting Standards Board (IASB) since 1 July 2011.

Adolf Marcus "Dolf" Joekes was a Dutch politician and diplomat of the defunct Free-thinking Democratic League (VDB) and later co-founder of the Labour Party (PvdA) and businessman.

Hugo Mattheüs de Jonge is a Dutch politician serving as first Deputy Prime Minister of the Netherlands and Minister of Health, Welfare and Sport since 2017 in the Third Rutte cabinet. A member of the Christian Democratic Appeal (CDA), he was elected to its leadership in 2020 for the upcoming general election. He withdrew later that year, citing an impossibility to combine his position as Health Minister in charge of the COVID-19 pandemic efforts with his party leadership.

Abraham "Ab" Klink is a retired Dutch politician of Christian Democratic Appeal (CDA) and sociologist. He is a corporate director of the VGZ Cooperative since 1 January 2014 and a professor at the Vrije Universiteit Amsterdam for Healthcare, Labor and Political Guidance since 1 January 2011.

Victor Gerard Marie "Vic" Marijnen was a Dutch politician of the defunct Catholic People's Party (KVP) now the Christian Democratic Appeal (CDA) party and jurist who served as Prime Minister of the Netherlands from 24 July 1963 until 14 April 1965.

Jozef Marie Mathias "Jo" Ritzen is a retired Dutch politician of the Labour Party (PvdA) and economist.

Bauke Roolvink was a Dutch politician of the defunct Anti-Revolutionary Party (ARP) now merged into the Christian Democratic Appeal (CDA) party and trade union leader

Charles Joan Marie Adriaan van Rooy was a Dutch politician of the defunct Catholic People's Party (KVP) now merged into the Christian Democratic Appeal (CDA).

Edith Ingeborg Schippers is a retired Dutch politician of the People's Party for Freedom and Democracy (VVD) and businesswoman serving as President of the DSM Company since 1 February 2019.

Lodewijk Benedictus Johannes "Louis" Stuyt was a Dutch politician of the defunct Catholic People's Party (KVP) now merged into the Christian Democratic Appeal (CDA) and physician.

Jacobus Gerardus "Ko" Suurhoff was a Dutch politician of the defunct Social Democratic Workers' Party (SDAP) and co-founder of the Labour Party (PvdA) and trade union leader.

Gerardus Mattheus Johannes "Gerard" Veldkamp was a Dutch politician of the defunct Catholic People's Party (KVP) now merged into the Christian Democratic Appeal (CDA) party and economist.

Irene Vorrink was a Dutch politician of the Labour Party (PvdA).