
Africander was an American Thoroughbred Champion racehorse.

American Pharoah is an American Thoroughbred racehorse who won the American Triple Crown and the Breeders' Cup Classic in 2015. He was the 12th Triple Crown winner in history, and in winning all four races, became the first horse to win the Grand Slam of Thoroughbred racing. He won the 2015 Eclipse Award for Horse of the Year and 2015 Champion three-year-old. He was bred and owned throughout his racing career by Ahmed Zayat of Zayat Stables, trained by Bob Baffert, and ridden in most of his races by Victor Espinoza. He now stands at stud at Ashford Stud in Kentucky.

Arrogate was an American Thoroughbred racehorse who won the 2016 Travers Stakes in a track record time in his first stakes appearance. He then won the Breeders' Cup Classic and was named the American Champion Three-Year-Old Male Horse and World's Best Racehorse of 2016. To start his four-year-campaign, he won the 2017 Pegasus World Cup in a new track record followed by a win in the Dubai World Cup. On returning to the United States however, he suffered three straight defeats and retired with a record of seven wins from eleven starts. Despite having only four stakes race wins, the large purses for these wins made him the all-time leading money earner in North America.

Ballot was an American two-time Champion Thoroughbred racehorse and damsire of the very important sire, Bull Lea.

Billy Kelly was an American Thoroughbred racehorse who was the champion two-year-old in 1918 when he won 14 of 17 starts. Favored for the 1919 Kentucky Derby, he lost to his stablemate, the then lightly regarded Sir Barton, but Billy Kelly would beat Sir Barton in 8 of 12 head to head races. Billy Kelly would go on to win 39 races from 69 starts. He was elected to the National Museum of Racing and Hall of Fame in 2015.

Bret Hanover was an outstanding American Standardbred racehorse. He was one of only nine pacers to win harness racing's Triple Crown of Harness Racing for Pacers and won 62 of 68 starts. He was the first horse to be voted United States Harness Horse of the Year three times and remains the only pacer to have received that honor.

Broomstick (1901–1931) was a Thoroughbred race horse whose most important win was in the 1904 Travers Stakes. After retirement, he became one of the great sires in American racing history, leading the North American sire list in 1913, 1914 and 1915. He was inducted into the National Museum of Racing and Hall of Fame in 1956.

Citation was widely regarded one of the greatest thoroughbreds of all time and an American Triple Crown-winning Thoroughbred racehorse who won 16 consecutive races in major stakes race competition. He was the first horse in history to win one million dollars.

Colin was a champion American Thoroughbred racehorse who was undefeated in 15 starts. In 1907, he swept the major two-year-old stakes races including the Belmont Futurity and Champagne Stakes and was the consensus Horse of the Year. His three-year-old campaign was cut short by injury but he was still Horse of the Year based on his three wins including the Belmont Stakes. As a sire, he suffered from fertility problems but still sired multiple stakes winners.

Count Fleet was a champion American thoroughbred racehorse. In 1943, he became the sixth American Triple Crown winner when he won the Belmont Stakes by a then record margin of twenty-five lengths. After an undefeated season, he was named the 1943 Horse of the Year and champion three-year-old. Also a champion at age two, he is ranked as one of the greatest American racehorses of the twentieth century. He was inducted into the National Museum of Racing and Hall of Fame in 1961.

Dan Patch was a noted American Standardbred pacer. At a time when harness racing was one of the largest sports in the nation, Dan Patch was a major celebrity. He was undefeated in open competition and was so dominant on the racetrack that other owners eventually refused to enter their horses against him. Instead, he ended his racing career performing time trials and traveled extensively on exhibition, earning millions of dollars in purses, attendance gate receipts and product endorsements. Dan Patch broke world speed records at least 14 times in the early 1900s. In 1905, he set a world's record for the fastest mile by a harness horse that stood unmatched for over 30 years. Unofficially, Dan Patch broke this record in 1906 with a clocking of 1:55. He died on July 11, 1916. His owner Marion Willis Savage died just one day later.

Domino (1891–1897) was a 19th-century American thoroughbred race horse.

Dubai Millennium (1996–2001) was a Thoroughbred racehorse and sire, trained in the United Kingdom and Dubai during his racing career which ran from 1998 and 2000. He is notable for winning a series of major races in 1999 and 2000 including the Dubai World Cup. He died after contracting grass sickness at the age of five.

Easy Goer was an American Champion Hall of Fame Thoroughbred racehorse known for earning American Champion Two-Year-Old Colt honors in 1988 and defeating 1989 American Horse of the Year Sunday Silence in the Belmont Stakes by eight lengths. Both horses were later voted into the American Hall of Fame. The victory deprived Sunday Silence of the Triple Crown. It was also the second-fastest Belmont in history, behind only the record performance of Secretariat in 1973. Easy Goer was the first two-year-old champion to win a Triple Crown race since Spectacular Bid in 1979. Easy Goer also ran the fastest mile on dirt by any three-year-old in the history of Thoroughbred racing with a time of 1:32 2⁄5, which was a second faster than Secretariat's stakes record, and one-fifth of a second off of the world record set by Dr. Fager in 1968.

Fair Play was an American-bred Thoroughbred racehorse who was successful on the track, but even more so when retired to stud. He is best known as the sire of Man o' War, widely considered one of the greatest American racehorses of all time. On the racetrack, Fair Play was known for his rivalry with the undefeated Colin, to whom he finished second in the Belmont Stakes. Later, Fair Play was the leading sire in North America of 1920, 1924 and 1927, and the leading broodmare sire of 1931, 1934 and 1938. He was inducted into the National Museum of Racing and Hall of Fame in 1956.

Forego was an American Thoroughbred racehorse that won eight Eclipse Awards including Horse of the Year, Champion Handicap Horse and Champion Sprinter.

Frosted is an American Thoroughbred racehorse. In 2016, he set a stakes record while winning the Metropolitan Handicap in a "dazzling performance" and followed up with a win in the Whitney Handicap. Prior to that, despite winning several stakes races, he was best known for finishing behind American Pharoah four times, including a runner-up performance in the 2015 Belmont Stakes.

Gold Heels was an American Thoroughbred Champion racehorse who, in a two-year period, set one new stakes record and four track records, including a world record.

Goldencents is an American Thoroughbred racehorse best known for winning consecutive runnings of the Breeders' Cup Dirt Mile. As a two-year-old he ran three times, winning the Delta Jackpot Stakes and finishing second in the Champagne Stakes. In the following year he won the Sham Stakes and the Santa Anita Derby before finishing unplaced in the Kentucky Derby and the Preakness Stakes. He was brought back to sprint distances and ran well without winning before taking the Breeders' Cup Dirt Mile. As a four-year-old he won the Pat O'Brien Stakes and finished second three times before winning his second Breeders' Cup Dirt Mile.

Irish Lad (1900–1925) was an American Thoroughbred Champion racehorse and a world record holder.

John Henry was an American champion Thoroughbred racehorse. He was sired by Ole Bob Bowers out of Once Double. John Henry had 39 wins with $6,591,860 in earnings, was twice voted the Eclipse Award for Horse of the Year, and was listed as #23 on Blood Horse magazine's Top 100 U.S. Racehorses of the 20th Century.

Kingston (1884–1912) was an American Thoroughbred racehorse. He won 89 races, the most in the history of the sport of thoroughbred racing. Of his 138 starts, he was out of the money only on four occasions. He was later inducted into the United States Racing Hall of Fame.

Kona Gold was an American Champion Thoroughbred racehorse.

Lava Man is an American Thoroughbred racehorse who was once claimed for $50,000 but wound up being inducted into the National Museum of Racing and Hall of Fame in 2015. In a forty-seven race career, despite finishing off the board while losing all 5 of his races outside California, he won seventeen times with his major victories including three Hollywood Gold Cups, two Santa Anita Handicaps and the Pacific Classic Stakes.

Leroidesanimaux was a Thoroughbred racehorse who competed in Brazil and was an Eclipse Award winner in the United States.

Man o' War was an American Thoroughbred who is widely considered one of the greatest racehorses of all time. Several sports publications, including The Blood-Horse, Sports Illustrated, ESPN, and the (AP) Associated Press, voted Man o' War as the outstanding horse of the 20th century. During his racing career, just after World War I, Man o' War won 20 of 21 races and $249,465 in purses. He was the unofficial 1920 American horse of the year and was honored with Babe Ruth as the outstanding athlete of the year by The New York Times. He was inducted into the National Museum of Racing and Hall of Fame in 1957. On March 29, 2017, the museum opened a special exhibit in his honor, "Man o' War at 100".

Midnight Lute is an American Thoroughbred racehorse. He was named American Champion Sprint Horse in 2007.

Milkmaid was an American two-time Champion Thoroughbred racehorse. She was bred by J. Hal Woodford at his farm in Bourbon County, Kentucky. Woodford had bred and raced the 1907 Kentucky Derby winner, Pink Star. Out of the mare, Nell Olin, her sire was the British import, Peep o' Day, a son of the great Ayrshire who won the 1888 2,000 Guineas Stakes and Epsom Derby then just missed winning the British Triple Crown when he ran second in the St. Leger Stakes.

Mr. Prospector was a Thoroughbred racehorse who became an outstanding breeding stallion and notable sire of sires. A sprinter whose career was cut short by repeated injuries, he won seven of his 14 starts, including the Gravesend Handicap at Aqueduct Racetrack and the Whirlaway Handicap at Garden State Park.

Northern Dancer was a Thoroughbred who in 1964 became the first Canadian-bred horse to win the Kentucky Derby. He then became one of the most successful sires of the 20th century. He is considered a Canadian icon, and was inducted into the Canadian Sports Hall of Fame in 1965. Induction into the Racing Hall of Fame in both Canada and the United States followed in 1976. As a competitor, The Blood-Horse ranked him as one of the top 100 U.S. Thoroughbred racehorses of the 20th century. As a sire of sires, his impact on the breed is still felt worldwide.

Omar Khayyam (1914–1938) was a British-born Thoroughbred racehorse who was sold as a yearling to an American racing partnership and who became the first foreign-bred horse to win the Kentucky Derby. He was named for the famous Persian mathematician, poet, and astronomer, Omar Khayyam.

Raise a Native was an undefeated Thoroughbred racehorse that was named 1963 champion two-year-old colt in the Turf and Sport Digest poll and was the highest rated juvenile in the Experimental Free Handicap. He sired 74 stakes winners, including Majestic Prince and Alydar. In its 1988 obituary for the horse, The New York Times called him "the most influential sire of American Thoroughbred stallions over the last 20 years".

Round Table was an American Thoroughbred Hall of Fame racehorse. He is considered the greatest turf horse in American racing history.

Ruffian was an American champion thoroughbred racehorse who won 10 consecutive races, usually by wide margins. In July 1975, she entered a highly anticipated match race with Kentucky Derby winner Foolish Pleasure, in which she broke down. Surgery was attempted but Ruffian reacted poorly and exacerbated the injuries while coming out of anesthesia. As a result, she was euthanized. Ruffian was ranked among the top U.S. racehorses of the 20th century by The Blood-Horse magazine. Her story was told in the 2007 film Ruffian and numerous books.

Seabiscuit was a champion thoroughbred racehorse in the United States who became the top money winning racehorse up to the 1940s. He beat the 1937 Triple-Crown winner, War Admiral, by 4 lengths in a 2-horse special at Pimlico and was voted American Horse of the Year for 1938.

Seattle Slew was an American Thoroughbred race horse who won the Triple Crown in 1977 — the tenth of thirteen horses to accomplish the feat. He is one of two horses to have won the Triple Crown while having been undefeated in any previous race; the second was Justify, who won the Triple Crown in 2018 and who is descended from Seattle Slew. Honored as the 1977 Horse of the Year, he was also a champion at ages two, three, and four. In the Blood-Horse magazine List of the Top 100 U.S. Racehorses of the 20th Century Seattle Slew was ranked ninth.

Secretariat was an American Thoroughbred racehorse who, in 1973, became the first Triple Crown winner in 25 years. His record-breaking victory in the Belmont Stakes, which he won by 31 lengths, is widely regarded as one of the greatest races in history. During his racing career, he won five Eclipse Awards, including Horse of the Year honors at ages two and three. He was nominated to the National Museum of Racing and Hall of Fame in 1974. In the List of the Top 100 U.S. Racehorses of the 20th Century, Secretariat is second only to Man o' War, who also was a large chestnut colt given the nickname "Big Red".

Sir Barton was a chestnut Thoroughbred race horse who in 1919 became the first winner of what would come to be known as the American Triple Crown.

Spectacular Bid was a champion American Thoroughbred racehorse, who holds the world record for the fastest 1 1/4 miles on the dirt. In a racing career which lasted from 1978 through 1980, Spectacular Bid won 26 of his 30 races, including the Kentucky Derby and the Preakness Stakes. In his career, Spectacular Bid earned a then-record sum of US$2,781,607. He also won Eclipse Awards in each of his three racing seasons.

Star Pointer (1889–1910) was the first Standardbred race horse to complete a mile in less than two minutes. He was a pacer by Brown Hal out of Sweepstakes.

Sun Briar was a Thoroughbred racehorse retrospectively named the American Champion Two-Year-Old Colt of 1917 and the American Champion Older Male Horse of 1919 by writers from The Blood-Horse magazine. He was a son of Sundridge, the 1911 Champion sire in Great Britain who also sired Epsom Derby winner Sunstar. Sun Briar was out of the mare Sweet Briar, the daughter of St. Frusquin, a multiple winner of top-level races including the 1896 British Classic and the 2,000 Guineas Stakes. St. Frusquin was also a leading sire in Great Britain and Ireland in 1903 and the Leading broodmare sire in Great Britain & Ireland in 1924.

Wajima was an American Champion Thoroughbred racehorse.

War Admiral was an American Thoroughbred racehorse, best known as the fourth winner of the American Triple Crown and Horse of the Year in 1937, and rival of Seabiscuit in the 'Match Race of the Century' in 1938. During his career toward the end of the Great Depression, War Admiral won 21 of his 26 starts with earnings of $273,240 After his retirement to stud, he was the leading sire in North America for 1945 and was also an outstanding broodmare sire whose influence is still felt today in descendants such as American Pharoah and Justify.

Waya (1974–2001) was a French Thoroughbred World Record holding racehorse who competed successfully in France and was a Champion in the United States. She was bred by the prominent French horseman Daniel Wildenstein through his breeding company, Dayton Ltd. Out of the mare War Path, her sire was Wildenstein's stallion Faraway Son, a Group 1 winner and the 1971 French Champion Miler.

Whirlaway was an American champion thoroughbred racehorse. The chestnut horse was sired by English Derby winner Blenheim, out of the broodmare Dustwhirl. Whirlaway was bred at Calumet Farm in Lexington, Kentucky. Trained by Ben A. Jones and ridden by Eddie Arcaro, Whirlaway won the U.S. Triple Crown in 1941. With his win in the Travers Stakes, he remains to this day the only horse to have won the Superfecta. Whirlaway was widely known as "Mr. Longtail" because his tail was especially long and thick and it would blow far out behind him during races, flowing dramatically in the wind.

Whisk Broom II (1907–1928) was an American-bred Thoroughbred racehorse who raced in the United Kingdom and in the United States. Whisk Broom showed high class form during four seasons of racing in Europe, but produced his best performances when returning to America in 1913. He claimed the New York Handicap Triple by winning the Metropolitan Handicap, the Brooklyn Handicap, and the Suburban Handicap, a feat unmatched until Tom Fool achieved it forty years later. Kelso in 1961 and Fit To Fight in 1984 later joined them as the only other horses to win the Handicap Triple. Whisk Broom II's career was ended by injury after his triple success, but he went on to become a successful breeding stallion.

Whitmore is an American Thoroughbred racehorse who was named the American Champion Sprint Horse of 2020 after winning the Breeders' Cup Sprint at age seven. He had previously finished eighth in that race in 2017 as a four-year old, second in 2018 and third in 2019. His other major wins include the Phoenix Stakes in 2017 and Forego Stakes in 2018. He is also known for his winning record at Oaklawn Park, where he won the listed Hot Springs Stakes four times in a row and the Count Fleet Sprint Handicap three times. His career earnings are over $4.2 million.

Winx is a retired champion Australian Thoroughbred racehorse. Between May 2015 and her retirement in April 2019, she won 33 consecutive races including 25 Group 1s, at distances ranging from 1300 metres to 2200 metres. In the World's Best Racehorse Rankings, she was the second-ranked filly or mare in 2015, improving in 2016 to become both the world's top-ranked filly or mare and the world's top-ranked turf horse. She retained this ranking in 2017 and in 2018 was co-ranked as the best horse in the world. In 2017 she was inducted into the Australian Racing Hall of Fame, only the third horse to earn this honour while still in training. Over her career, she earned more than 26 million Australian dollars.

Wise Dan is a champion American Thoroughbred racehorse. He is the first horse to win the same three Eclipse Awards in consecutive years, having been named American Horse of the Year, Champion Older Male and Champion Male Turf Horse in 2012 and 2013.

Zenyatta is a retired American Thoroughbred race horse mare, winner of 19 starts in a 20-race career. Her sole defeat came in her final race, the 2010 Breeders' Cup Classic where she lost by a neck to Blame in an attempt to repeat her win in the 2009 event. Despite the loss, she was named the 2010 American Horse of the Year. She was also the American Champion Older Female Horse in 2008, 2009 and 2010. She was inducted into the National Museum of Racing and Hall of Fame in 2016.