
Chris Byrd vs. Wladimir Klitschko II, billed as "Revenge Is The Name Of The Game", was a professional boxing match contested on 22 April 2006 for the IBF and vacant IBO heavyweight championship.

Joe Calzaghe vs. Jeff Lacy was a boxing match that took place on March 4, 2006 in Manchester, England for the WBO, IBF, & The Ring titles. Dubbed "Judgement day", it pitted long-time WBO champion Calzaghe against up and coming IBF champion, American Jeff "Left Hook" Lacy.

Ricardo Mayorga vs. Oscar De La Hoya, billed as "Danger Zone", was a professional boxing match contested on May 6, 2006 for the WBC light middleweight title.

Floyd Mayweather Jr. vs. Carlos Baldomir, billed as Pretty Risky, was a boxing match for the World Boxing Council and The Ring (magazine) Welterweight titles. The bout was held on November 4, 2006, at the Mandalay Bay Resort and Casino in Las Vegas, Nevada. The event also featured Robert Guerrero vs. Orlando Salido for the International Boxing Federation Featherweight title. Floyd Mayweather won this bout by a unanimous decision.

"Mayweather vs. Judah: Sworn Enemies" was a boxing IBF Welterweight championship which took place on April 8, 2006, at the Thomas and Mack Center in Paradise, Nevada between IBF Welterweight Champion Zab Judah and undefeated three-division champion Floyd Mayweather Jr..

Pacquiao vs. Larios, also billed as Mano-A-Mano and Thrilla in Manila 2, was a professional boxing super featherweight fight held on July 2, 2006 at the Araneta Coliseum, Quezon City, in the Philippines and was a production of ABS-CBN Sports and promoted by Manny Pacquiao Promotions and Golden Boy Promotions. The judges were Humbert Furgoni from France, Daniel van de Wiele from Belgium, and Noppharat Srichharoen from Thailand with referee Bruce McTavish and ring announcer Michael Buffer. It was aired live in free-to-air television network ABS-CBN, worldwide through The Filipino Channel, and through pay per view on In Demand, HBO, DirecTV, and SkyCable. Pacquiao won the fight via unanimous decision, knocking down Larios two times. The three judges scored the fight 117–110, 118–108 and 120–106 all for Pacquiao.

Manny Pacquiao vs. Érik Morales II, billed as The Battle, was a super featherweight boxing match. The bout took place on January 21, 2006 at the Thomas & Mack Center, Las Vegas, Nevada, United States and was distributed by HBO PPV. The bout is the second of the Pacquiao-Morales trilogy, widely considered as one of the greatest boxing trilogies of all time.

Manny Pacquiao vs. Érik Morales III, billed as The Grand Finale, was a super featherweight boxing match. The bout took place on November 18, 2006 at the Thomas & Mack Center, Las Vegas, Nevada, United States and was distributed by HBO PPV. The bout is the last of the Pacquiao-Morales trilogy, widely considered as one of the greatest boxing trilogies of all time. The fight also marked a return to HBO for Pacquiao, and his first fight in his four-year contract with Top Rank as his promoter.