
The Mesoamerican Barrier Reef System (MBRS), also popularly known as the Great Mayan Reef or Great Maya Reef, is a marine region that stretches over 1,126 kilometres (700 mi) along the coasts of four countries – Mexico, Belize, Guatemala, and Honduras – from Isla Contoy at the northern tip of the Yucatán Peninsula south to Belize, Guatemala and the Bay Islands of Honduras. The reef system includes various protected areas and parks including the Belize Barrier Reef, Arrecifes de Cozumel National Park, Hol Chan Marine Reserve (Belize), Sian Ka'an biosphere reserve, and the Cayos Cochinos Marine Park. Belize's coastline, including the Belize Barrier Reef, is home to approximately 30% of the Mesoamerican Barrier Reef System.

The Arrecifes de Cozumel National Park is off the coast of the island of Cozumel in the state of Quintana Roo, Mexico. The Cozumel reef system is part of the Mesoamerican Barrier Reef System, the second largest coral reef system in the world. Even though almost the entire island of Cozumel is surrounded by coral reefs, the park only encompasses the reefs on the south side of the island. It begins just south of the International Pier and continues down and around Punta Sur and up just a small portion of the east side of the island. The park contains both shallow and mesophotic coral reefs and extends to the 100 m depth isobar.

Bacalar Chico National Park and Marine Reserve (BCNPMR) is a protected area and UNESCO World Heritage Site on the northern part of Ambergris Caye in Belize.

The Belize Barrier Reef is a series of coral reefs straddling the coast of Belize, roughly 300 meters (980 ft) offshore in the north and 40 kilometers (25 mi) in the south within the country limits. The Belize Barrier Reef is a 300-kilometer (190 mi) long section of the 900-kilometer (560 mi) Mesoamerican Barrier Reef System, which is continuous from Cancún on the north-eastern tip of the Yucatán Peninsula through the Riviera Maya and down to Honduras, making it the second largest coral reef system in the world after the Great Barrier Reef in Australia. It is Belize's top tourist destination, popular for scuba diving and snorkeling and attracting almost half of its 260,000 visitors. It is also vital to the country's fishing industry.

Gladden Spit and Silk Cayes Marine Reserve (GSSCMR) is a protected marine reserve in the central part of Belize's Barrier Reef. It covers approximately 25,980 acres (10,510 ha) lying 36 kilometres (22 mi) off the coast of Placencia. Established in 2003, The reserve comes under the authority of the government's Fisheries Department, but is managed by the Southern Environmental Association, a community-based organisation.

The Great Blue Hole is a giant marine sinkhole off the coast of Belize. It lies near the center of Lighthouse Reef, a small atoll 70 km (43 mi) from the mainland and Belize City. The hole is circular in shape, 318 m (1,043 ft) across and 124 m (407 ft) deep. It was formed during several episodes of quaternary glaciation when sea levels were much lower. Analysis of stalactites found in the Great Blue Hole shows that formation took place 153,000; 66,000; 60,000; and 15,000 years ago. As the ocean began to rise again, the cave was flooded. The Great Blue Hole is a part of the larger Belize Barrier Reef Reserve System, a World Heritage Site of the United Nations Educational, Scientific and Cultural Organization (UNESCO).

Hol Chan Marine Reserve is a marine reserve close to Ambergris Caye and Caye Caulker, off the coast of Belize. It covers approximately 18 km² (4,448 acres) of coral reefs, seagrass beds, and mangrove forest. Hol Chan is Mayan for "little channel".
Isla Contoy is a small island in the Mexican state of Quintana Roo, approximately 30 kilometers north of Isla Mujeres. The island is only 8.5 km (5.3 mi) in length and has an area of 3.17 square kilometres (1.22 sq mi).

Port Honduras Marine Reserve is a national protected marine reserve in the Toledo district of Belize. It was established in January 2000, and covers 40,470 hectares of mangrove and coastal ecosystems. It encompasses over one hundred small, mangrove-fringed cayes, benthic habitats comprising soft-bottom seagrass beds and fringing reefs.

South Water Caye Marine Reserve is the largest marine reserve in the Stann Creek district of Belize. It was established in 1996 and covers 47,702 hectares of mangrove and coastal ecosystems.