
In 7 BC, Augustus divided the city of Rome into 14 administrative regions. These replaced the four regiones — or "quarters" — traditionally attributed to Servius Tullius, sixth king of Rome. They were further divided into official neighborhoods.

The Regio I Porta Capena is the first regio of imperial Rome, under Augustus's administrative reform. Regio I took its name from the Porta Capena, a gate of the Servian Walls, through which the Appian Way entered the city prior to the construction of the Aurelian Walls.

The Regio II Caelimontium is the second regio of imperial Rome, under Augustus's administrative reform. It took its name from the Caelian Hill, which the region was centred on.

The Regio III Isis et Serapis was the third regio of imperial Rome, under Augustus's administrative reform. Regio III took its name from the double sanctuary of Isis and Serapis, in the area of the Via Praenestina, containing the valley that was to be the future site of the Colosseum, and parts of the Oppian and Esquiline hills.

The Regio IV Templum Pacis is the fourth regio of imperial Rome, under Augustus's administrative reform. Regio IV took its name from the Temple of Peace built in the region by the emperor Vespasian. It includes the valley between the Esquiline and the Viminal hills, the popular area of the Subura, and the Velian Hill.

The Regio IX Circus Flaminius is the ninth regio of imperial Rome, under Augustus's administrative reform. Regio IX took its name from the racecourse located in the southern end of the Campus Martius, close to Tiber Island.

The Regio V Esquiliae is the fifth regio of imperial Rome, under Augustus's administrative reform. Regio V took its name from the Esquiline Hill. It contains parts of the Oppian Hill and Cispian Hill and of the Esquiline, plus the plain just outside the Servian walls.

The Regio VI Alta Semita is the sixth regio of imperial Rome, under Augustus's administrative reform. Regio VI took its name from the street passing over the Quirinal Hill. It was a large regio that also encompassed the Viminal Hill, the lower slopes of the Pincian, and the valleys in-between.

The Regio VII Via Lata is the seventh regio of imperial Rome, under Augustus's administrative reform. Regio VII took its name from the wide urban street the Via Lata. It was the urban section of the Via Flaminia, which ran between the Servian walls and the Aurelian Walls, and corresponds to the modern Via del Corso. The regio contained part of the Campus Martius on the east of the street plus the Collis Hortulorum, the Pincian Hill.

The Regio VIII Forum Romanum Magnum is the eighth regio of imperial Rome, under Augustus's administrative reform. Regio VIII took its name from the Roman Forum, the political epicentre of Ancient Rome.

The Regio X Palatium is the tenth regio of imperial Rome, under Augustus's administrative reform. Regio X took its name from the Palatine Hill and the imperial palaces located on it.

The Regio XI Circus Maximus is the eleventh regio of imperial Rome, under Augustus's administrative reform. Regio XI took its name from the Circus Maximus, located in the valley between the Palatine and the Aventine hills.

The Regio XII Piscina Publica is the twelfth regio of imperial Rome, under Augustus's administrative reform. Regio XII took its name from the Piscina Publica, a swimming pool that disappeared during the middle imperial period.

The Regio XIII Aventinus is the thirteenth regio of imperial Rome, under Augustus's administrative reform. Regio XIII took its name from the hill which dominated the region, the Aventine.

The Regio XIV Transtiberim is the fourteenth regio of imperial Rome, under Augustus's administrative reform. Meaning "across the Tiber", the Regio took its name from its position on the east bank of the Tiber River.