
The Aitape River is a river in the Aitape area of northern Papua New Guinea.

The Arafundi River is a river in northern Papua New Guinea.

The Arai River is a river in southern Papua New Guinea.

The Aramia River is a river in southwestern Papua New Guinea.

The Awung River is a river in northern Papua New Guinea.

The Bamu River is a river in southwestern Papua New Guinea.

The Bapi River or Keri River is a river in northern Papua New Guinea.

The Bensbach River is a river in southwestern Papua New Guinea. It is located just to the east of the Maro River in Merauke Regency, Indonesia, and just to the west of the Morehead River in Papua New Guinea.

The Bigei River or Peka River is a river in northern Papua New Guinea.

Boiken Creek is a creek in northern Papua New Guinea.

The Elevala River is a river in southwestern Papua New Guinea.

The Evapia River is a river in northern Papua New Guinea.

The Fly River is the third longest river in the island of New Guinea, after the Sepik River and Mamberamo River with a total length of 1,060 km (660 mi) and the largest by volume of discharge in Oceania, the largest in the world without a single dam in its catchment, and overall the 25th-largest primary river in the world by discharge volume. It is located in the southwest of Papua New Guinea and Papua Province of Indonesia. It rises in the Victor Emanuel Range arm of the Star Mountains, and crosses the south-western lowlands before flowing into the Gulf of Papua in a large delta.

The Frieda River is a river in northern Papua New Guinea.

The Gilagil River is a river in northern Papua New Guinea.

The Guabe River is a river in northern Papua New Guinea.

The Guam River is a river in northern Papua New Guinea.

The Jimi River is a river in Western Highlands Province, Papua New Guinea.

The Kaugel River is a river in Western Highlands Province, Papua New Guinea. With a total length of 112.6 km (70.0 mi) it is one of the major tributary of Purari River.

The Kaukomba River is a small river of Madang Province in Papua New Guinea. It joins Jabab Creek to form the Toto River, which enters the ocean just east of the village of Asuramba. It is located 600 km from Port Moresby.

The Keram River is a river in northern Papua New Guinea.
The Kikori River is a major river in southern Papua New Guinea on the island of New Guinea. With a total length of 445 km (277 mi) long and flows southeast into the Gulf of Papua, with its delta at the head of the gulf. The settlement of Kikori lies on the delta.

The Kumil River is a river in northern Papua New Guinea.

The Kumusi River is a river located in the Oro Province of Papua New Guinea. Known for its width and its strength, the Kumusi has had a significant impact on the history of the Oro Province. It was a significant factor in the Kokoda Track Campaign and also a contributing factor to the destruction caused by Cyclone Guba.

Lamari River is a river that originates in Kratke Range in the south central highlands of Eastern Highlands Province of Papua New Guinea. It flows into the Purari River basin.

The Left May or Arai River is a river in northern Papua New Guinea.

The Leonard Schultze River or Leonhard Schultze River is a river in northern Papua New Guinea. It is named after German explorer Leonhard Schultze-Jena.

Malas River is a river in Madang Province, Papua New Guinea. It rises in the Adelbert Range and empties to the Bismarck Sea at 4.6666667°S 145.5833333°E.
Mambare River is a river in Oro Province, Papua New Guinea, located at 8.05°S 148.0333333°E.

The Markham River is a river in eastern Papua New Guinea. It originates in the Finisterre Range and flows for 180 km (110 mi) to empty into the Huon Gulf at Lae.

The Masaweng River is a river in northern Papua New Guinea.

The Mindjim River is a river in northern Papua New Guinea.

The Moam River is a river in northern Papua New Guinea.

The Morehead River is a river in southwestern Papua New Guinea. It is located just to the east of the Bensbach River, and to the west of the Fly River. The river flows through the Trans-Fly savanna and grasslands.

The Musa is a river on the eastern side of the Papuan Peninsula, in Papua New Guinea.

The Nuru River is a river in northern Papua New Guinea.
The Ok Tedi is a river in New Guinea. The Ok Tedi Mine is located near the headwaters of the river, which is sourced in the Star Mountains. It is the second largest tributary of the Fly River. Nearly the entirety of the river runs through the North Fly District of the Western Province of Papua New Guinea, but the river crosses the international boundary with Indonesia for less than one kilometre. The largest settlement of the Western Province, Tabubil is located near its banks.

The Omati River is a river in southern Papua New Guinea.

The Pahoturi, or Paho River, is a river in southwestern Papua New Guinea.

The Piore River is a river in northern Papua New Guinea.

The Pual River is a river in northern Papua New Guinea.

The Purari is a river in that originates in the south central highlands especially in Kandep District of Enga Province of Papua New Guinea, flowing 470 kilometres (292 mi) though the Gulf Province to the Gulf of Papua. The Purari has a 33,670 km2 (13,000 sq mi) drainage basin and is the third largest river in Papua New Guinea.

The Ramu River is a major river in northern Papua New Guinea. The headwaters of the river are formed in the Kratke Range from where it then travels about 640 km (398 mi) northwest to the Bismarck Sea.

Segero Creek is a creek located in Western Province, Papua New Guinea.

The Senu River is a river in Sandaun Province, Papua New Guinea.

The Sepik River is the longest river on the island of New Guinea, and after the Fly and the Mamberamo the third largest by volume. The majority of the river flows through the Papua New Guinea (PNG) provinces of Sandaun and East Sepik, with a small section flowing through the Indonesian province of Papua.

The Soari River is a river in Papua New Guinea. It is located in Western Province, in the southwest of the country, 500 km west of Port Moresby.

Sogeram River is a river in Madang Province, Papua New Guinea. It empties into the Ramu River at 4.8°S 144.7333333°E.

The Strickland River is a major river in the Western Province of Papua New Guinea. It is the largest tributary of the Fly River with a total length of 824 km (512 mi) including the Lagaip River the main river source of the Strickland River. It was named after Edward Strickland, vice-president of the Geographical Society of Australasia by the New Guinea Exploration Expedition of 1885.

The Timper River is a river in northern Papua New Guinea.

The Torokina River is a river on Bougainville Island, within the Autonomous Region of Bougainville, in northeastern Papua New Guinea.

The Tua River is a tributary of the Purari River of Papua New Guinea. It originates in the Eastern Highlands Province and flows through the highlands of the Simbu Province, where it joins the Pio River, giving rise to the Purari.

The Turama River is a river of Papua New Guinea. Approximately 10 miles wide at the mouth, with a total length of 302 km (188 mi), it narrows rapidly. This, combined with its location at the head of the Gulf of Papua, results in tidal bores sweeping up the river. The effects are noticeable as far as 100 km upstream.

The Wassi Kussa River is a river in southwestern Papua New Guinea.
Wawoi River is a river located in Western Province, Papua New Guinea. With a total length of 482 km (300 mi) and has a drainage basin of 18,171 km2 (7,016 sq mi) its source is located in Mount Bosavi and flows southeast into the Gulf of Papua.

The Wogamush River is a river in northern Papua New Guinea.

The Yaganon River is a river in northern Papua New Guinea.

The Yellow River is a river in northern Papua New Guinea.

The Yuat is the major tributary of the Sepik River in northern Papua New Guinea. The Yuat is on the right (southern) side and joins the Sepik about 20 linear km upstream from the Keram River, and just downstream from the Chambri Lakes. The eponymous Yuat and Upper Yuat languages are spoken along the banks of the Yuat River.