Cuvieronius is an extinct New World genus of gomphotheres and is named after the French naturalist Georges Cuvier. Alive, specimens typically stood about 2.3 m (7.5 ft) tall at the shoulder, weighed about 3.5 t and would have superficially resembled a modern elephant with spiral-shaped tusks.

Glyptotherium is an extinct genus of glyptodont, a group of extinct mammals related to the armadillos living from the Middle to Late Pleistocene, approximately 1.8 million to 12,000 years ago (AEO). The genus is considered an example of North American megafauna, of which most have become extinct. Glyptotherium may have been wiped out by changing climate or human interference.

Hemiauchenia, synonym Tanupolama, is a genus of lamine camelids that evolved in North America in the Miocene period about 10 million years ago. This genus diversified and moved to South America in the Early Pleistocene, as part of the Great American Biotic Interchange, giving rise to modern lamines. The genus became extinct at the end of the Pleistocene.
Holmesina is a genus of pampathere, an extinct group of armadillo-like creatures that were distantly related to extant armadillos. Like armadillos, and unlike the other extinct branch of megafaunal cingulates, the glyptodonts, the shell was made up of flexible plates which allowed the animal to move more easily. Holmesina species were herbivores that grazed on coarse vegetation; armadillos are mostly insectivorous or omnivorous.

Mixotoxodon is an extinct genus of notoungulate of the family Toxodontidae inhabiting South America, Central America and parts of southern North America during the Pleistocene, from 1,800,000—12,000 years ago.
Nothrotherium is an extinct genus of medium-sized ground sloth from South America. It differs from Nothrotheriops in smaller size and differences in skull and hind leg bones, but both genera can be traced back to Hapalops, the genus which both evolved from in different ecological conditions.

Paramylodon is an extinct genus of ground sloth of the family Mylodontidae endemic to North America during the Pliocene through Pleistocene epochs, living from around ~4.9 Mya–11,000 years ago. It is also known as Harlan's ground sloth.

Platygonus is an extinct genus of herbivorous peccaries of the family Tayassuidae, endemic to North and South America from the Miocene through Pleistocene epochs, existing for about 10.289 million years .