
Layton Brothers: Mystery Room is a puzzle adventure video game for iOS and Android, published by Level-5. It is a spin-off of the Professor Layton series, following rookie investigator Lucy Baker, who works with genius detective Alfendi Layton, son of Hershel Layton, in a special department of Scotland Yard's crime investigation unit known as the "Mystery Room". The game was released in Japan on September 21, 2012, and in English on June 27, 2013. An Android version was released on September 5, 2013.

Layton's Mystery Journey: Katrielle and the Millionaires' Conspiracy is a puzzle video game developed and published by Level-5. It is the seventh main entry in the Professor Layton series and follows a new protagonist, Katrielle Layton. It was released for Android, iOS, and the Nintendo 3DS, in 2017, and for the Nintendo Switch in Japan in 2018, and worldwide in 2019. A manga adaptation of the game drawn by Hori Oritoka began serialization on March 20, 2018, in Shōgakukan's Ciao magazine, and an anime adaptation, Layton Mystery Tanteisha: Katori no Nazotoki File, began airing on Fuji TV and other channels in April 2018.

Professor Layton and the Azran Legacy is a puzzle game developed by Level-5 for the Nintendo 3DS. It is the sixth entry in the Professor Layton series, making up the third and final part of the prequel trilogy of games and according to Level 5 CEO Akihiro Hino, it will be the last Layton title to star Layton himself as the protagonist. The game saw a release in early to late 2013 in all territories except North America, where it was released on February 28 of the following year.
Professor Layton and the Curious Village is a puzzle adventure video game for the Nintendo DS system. It was developed by Level-5 and published by Level-5 in Japan and Nintendo worldwide. It was released in Japan during 2007, and in PAL regions and North America a year later in 2008. Curious Village is the first title in the Professor Layton series, directly followed by Professor Layton and the Diabolical Box. An enhanced mobile port of Curious Village featuring additional cutscenes, subtitled "HD for Mobile", was released in 2018.

Professor Layton and the Diabolical Box, known in Australia and Europe as Professor Layton and Pandora's Box, is the second game in the Professor Layton series by Level-5. It was followed by a third game, Professor Layton and the Unwound Future. The game follows Professor Layton and his self-proclaimed apprentice Luke as they travel cross-country by train to solve the mystery behind a mysterious box that is said to kill anyone who opens it. An enhanced mobile port of Diabolical Box, subtitled "HD for Mobile", was released on December 5, 2018.

Professor Layton and the Eternal Diva is a 2009 anime mystery film directed by Masakazu Hashimoto and produced by P.A.Works and OLM. The film is based on the Professor Layton video game series by Level-5, taking place between the events of the video games Professor Layton and the Last Specter and Professor Layton and the Miracle Mask. In the story, renowned opera star Janice Quatlane contacts her former teacher, Professor Hershel Layton, after encountering a young girl who claims to be the reincarnation of her dead friend. While Layton and his apprentice, Luke Triton, are attending one of Jancie's performances they get unwillingly pulled into a puzzle-themed battle royal where the winner will apparently receive "the gift of eternal life". According to Level-5, the film stays true to the games, with music, puzzles and characters.

Professor Layton and the Last Specter, known in Europe as Professor Layton and the Spectre's Call, is a puzzle adventure video game produced by Level-5 for the Nintendo DS handheld game console. Last Specter is the fourth game in the Professor Layton series, and is a prequel that takes place three years before the first trilogy, detailing how Professor Layton met his apprentice, Luke Triton and introducing Layton's assistant Emmy Altava.

Professor Layton and the Miracle Mask is a puzzle adventure video game developed by Level-5. It is the fifth game in the Professor Layton series, the second in the prequel trilogy of games, and the first in the series to be developed for the Nintendo 3DS. Miracle Mask was released as a launch title for the Nintendo 3DS in Japan in February 2011, becoming the best-selling game on the day of the system's launch. The game was later released worldwide in October 2012. Professor Layton and the Miracle Mask Plus, an enhanced edition featuring new puzzles and added cutscenes, was released on the Nintendo eShop in Japan in February 2013.

Professor Layton and the Unwound Future, known in Europe and Australia as Professor Layton and the Lost Future, is the third game in the first trilogy of the Professor Layton puzzle game series by Level-5. It was first released in Japan in November 2008 and was later released in North America in September 2010 and in Europe and Australia in October 2010. In the game, Layton meets an older version of his apprentice, Luke, who brings him to a terrible future he wishes him to help fix. The game was well received by critics. An enhanced mobile port of Unwound Future, subtitled "HD for Mobile", was released on July 13, 2020.

Professor Layton vs. Phoenix Wright: Ace Attorney is a visual novel adventure puzzle video game for the Nintendo 3DS, and was developed by both Capcom and Level-5, the latter publishing it in Japan while Nintendo published it worldwide. The game is a crossover between two games series from both developers, combining the puzzle and exploration elements of Level-5's Professor Layton series, and the general trial mechanics of Capcom's Ace Attorney adventure series, the latter enhanced by the addition of a few new elements. Shu Takumi, the series director for the Ace Attorney series, assisted with the scenario designs for the game. The plot focuses on Professor Layton and Phoenix Wright, along with their respective assistants, working together to solve the mystery behind a young girl that they both encounter separately, and a strange world they are brought to through her, with Layton focused on finding clues to solve the mystery, while Wright focuses on protecting people who are put on trial for being "witches".