
2B is the protagonist and initial player character of the 2017 video game Nier: Automata. A humanoid combat android created as part of the YoRHa squadron, her mission is to liberate Earth from hostile machine lifeforms created by an unnamed alien race. Her Type B designation indicates that she specializes in front-line combat, and she is able to wield two weapons and use a large variety of combat styles. Her personality is cold, collected, and quick-thinking in dire situations, a trait of her model line that was inherited from her predecessor A2, whom she resembles perfectly. She disdains open displays of emotion, believing them to be unnecessary, although she hides emotional trauma and anger over the missions she is forced to complete.

Alisa Bosconovitch is a video game character from the Tekken series developed by Namco Bandai Games, first appearing in Tekken 6: Bloodline Rebellion. Created by Dr. Bosconovitch, Alisa is a gynoid with detachable body parts. She and Lars Alexandersson are the main protagonists of the console versions of that game's Scenario Campaign mode. Her surname is commonly misspelled as "Boskonovitch", because her creator's surname is spelled that way. Alisa has received a generally positive reception from fans of the series, proving to be one of the more popular characters introduced in Tekken 6. She has been both praised and criticised for her character design.

Arcee is the name of several fictional characters in the Transformers franchise. They are female Autobots, usually pink or blue in color. Being the most famous of the Female Autobots, she has made more appearances and has had several more incarnations than any other female Transformer. Originally she turned into a car, however, later incarnations have turned into motorcycles. Arcee's design, alternate mode, and personality vary depending on continuity. Usually colored pink and white, she has also been depicted as a blue-colored character, and Botcon storyline saw her reformatted into a Maximal spider.

Bumblebee is a fictional robot superhero in the many continuities in the Transformers franchise. The character is a member of the Autobots, a group of sentient self-configuring modular extraterrestrial robotic lifeforms.

Clank is one of the titular protagonist game characters in the Ratchet & Clank video game series by Insomniac Games.

The Fallen is a fictional robot supervillain in the Transformers robot superhero franchise. According to Hasbro, he was formerly known as Megatronus Prime, and was a multiversal singularity, meaning that while he exists across the multiverse, this is no longer the case because of an event called The Shrouding, where all multiversal singularities within the Hasbro-Takara multiversal now exist as separate beings within each universe. As explained in more detail in the appropriate sections below, The Fallen has been given different origin stories in several of the different continuities in which he has appeared. Although the Fallen's origins are only suggested in his comic book appearance, they would be fully explained in Dorling Kindersley's Transformers: The Ultimate Guide.

Fulgore is a player character in the Killer Instinct series of fighting games by Rare. Fulgore was introduced in the original Killer Instinct in 1994 as an advanced fighting cyborg and a nemesis of the protagonist Jago. The character was met with positive critical reception and became an icon of the series.

GLaDOS is a fictional artificially superintelligent computer system from the video game series Portal. GLaDOS later appeared in The Lab and Lego Dimensions. The character was created by Erik Wolpaw and Kim Swift and voiced by Ellen McLain. GLaDOS is responsible for testing and maintenance in the Aperture Science Computer-Aided Enrichment Center in all titles. While GLaDOS initially appears in the first game to simply be a voice that guides the player, her words and actions become increasingly malicious as she makes her intentions clear. The second game, as well as the Valve-created comic Lab Rat, reveals that she was mistreated by the scientists and used a neurotoxin to kill the scientists in the laboratory before the events of Portal. She is apparently destroyed at the end of the first game but returns in the sequel, in which she is comically supplanted and temporarily stuck on a potato battery.

HK-47 is a fictional droid character in the 2003 video game Star Wars: Knights of the Old Republic, its 2004 sequel, Star Wars Knights of the Old Republic II: The Sith Lords, the Trials of Obi-Wan 2005 expansion pack to the massively multiplayer online game Star Wars Galaxies, and the MMORPG Star Wars: The Old Republic (2011). HK-47 was voiced by Kristoffer Tabori. HK-47 has been positively received for his characterization and humor.

Jack refers to multiple fictional characters in the game Tekken. The character is an android, first introduced under the name "Jack" in the original video game Tekken. Subsequent Tekken games feature an upgraded model with a slightly different name, with the exception of Tekken 4, in which he makes no appearance.

Jazz is a fictional robot character from the Transformers franchise. He is usually portrayed as a music-loving robot that speaks using American slang. In certain continuities he is shown as being Optimus Prime's good friend and right-hand man, but in all continuities, he transforms into some kind of sports car.

KOS-MOS is a fictional character from the Xenosaga role-playing video game series by Monolith Soft and Bandai Namco Entertainment. KOS-MOS also appears as a major character in the anime Xenosaga: The Animation and in several crossover video games.

Mega Man, known as Rockman in Japan, is the title character and the protagonist of the Mega Man series by Capcom. He was created by Akira Kitamura for the first Mega Man game released in 1987, with artist Keiji Inafune providing detailed character artwork based on Kitamura's pixel art design.

Mega Man X, known as Rockman X in Japan, with his name usually abbreviated to "X" , is the main protagonist of Capcom's Mega Man X video game series originating in the 1993 Super Nintendo video game Mega Man X. Mega Man X is an android who, along with his partner Zero, are elite members of the Maverick Hunters, a special police force tasked for defending humans and Reploids against criminal Reploids, known as Mavericks. Mega Man X has appeared in multiple printed adaptations of the series as well as an original video animation, Day of Sigma, which explores his early days as a hunter. Mega Man X is also a supporting character in the Mega Man Zero and Mega Man ZX video game series. Outside of the main Mega Man franchise, X has appeared in multiple crossover video games series.

Megatron is a character from the Transformers franchise created by American toy company Hasbro in 1984, based on a design by Japanese toy company Takara. The original Megatron was the leader and warlord of the Decepticons, a fictional faction of sentient self-configuring modular extraterrestrial robotic lifeforms from the planet Cybertron. He serves as the nemesis of the Autobot leader Optimus Prime. In most incarnations, after meeting his demise, usually at Optimus' hands, Megatron would be resurrected as Galvatron.

Mighty No. 9 is a 2016 action platform video game developed by Comcept, in conjunction with Inti Creates, and published by Deep Silver. The game was crowdfunded through Kickstarter and incorporated heavy input from the public. Mighty No. 9 closely resembles the early Mega Man series in both gameplay and character design, which project lead Keiji Inafune worked on, and is considered a spiritual successor.

Mother Brain is a fictional character created by Nintendo for the Metroid series. She is one of the most prominent antagonists within the series, serving as the main antagonist of Metroid and Super Metroid. It is revealed that she/it was created by the bird-like Chozo species.

HMX-12 Multi is a fictional character in Leaf's and Aquaplus' visual novel To Heart. In the visual novel, she is an experimental maid robot, and she made her first appearance as one of the game's ten female main characters. Multi was created by writer Tatsuya Takahashi, who wrote her scenario for the visual novel, and designed by illustrator Tōru Minazuki. She is voiced in Japanese by Yui Horie and by Tara Sands in the English version of the 1999 anime.

Optimus Prime, known in Japan as Convoy , is a fictional character created by the Transformers franchise. He is a Cybertronian, a fictional extraterrestrial species of sentient self-configuring modular robotic lifeforms, a synergistic blend of biological evolution and technological engineering. In almost every version of the mythos, Optimus is the leader of the Autobots, a faction of Transformers who are rivals of the Decepticons, another faction. He is defined by his strong moral character and is almost always portrayed as the primary hero of the story, opposing the evil Decepticon leader Megatron.

Proto Man, known in Japan as Blues , is a fictional character from Capcom's Mega Man video game series. Proto Man first appeared in the 1990 video game Mega Man 3, and was known as Break Man. At the end of Mega Man 3, Dr. Light reveals that Break Man's actual name is Proto Man, and that he is Mega Man's older brother.

R.O.B. is a toy robot accessory for the Nintendo Entertainment System (NES). It was launched in July 1985 as the Family Computer Robot in Japan, and October 1985 as R.O.B. in North America. Its short lifespan yielded only two games in the Robot Series: Gyromite and Stack-Up.

SHODAN is a fictional artificial intelligence and the main antagonist of the cyberpunk-horror themed video games System Shock and System Shock 2.

Wheatley is a fictional artificial intelligence from the Portal franchise first introduced in the 2011 video game Portal 2. He is voiced by British comedian and writer Stephen Merchant, and created in part by Portal 2's designer Erik Wolpaw.

Zero is a video game character present throughout Capcom's Mega Man franchise. Debuting in the Mega Man X series, Zero is a Maverick Hunter: A mechanical soldier in charge of defeating "Mavericks" and their more utilitarian counterparts ("Mechaniloids"). Zero also acts as a mentor and longtime friend to X, the main protagonist of the X series. He continues his role as the titular main protagonist of the Mega Man Zero series. Zero has also played a supporting role in other series in the franchise such as the Mega Man ZX series and appeared in crossover video games as a guest character.