
Ardour is a hard disk recorder and digital audio workstation application that runs on Linux, macOS, FreeBSD and Microsoft Windows. Its primary author is Paul Davis, who was also responsible for the JACK Audio Connection Kit. Ardour is intended to be digital audio workstation software suitable for professional use.

Audacity is a free and open-source digital audio editor and recording application software, available for Windows, macOS, Linux, and other Unix-like operating systems. Audacity was started in the fall of 1999 by Dominic Mazzoni and Roger Dannenberg at Carnegie Mellon University and was released on May 28, 2000 as version 0.8.

AV Linux is a Linux-based operating system aimed for multimedia content creators. Available for the i386 and x86-64 architectures with a kernel customised for maximum performance and low-latency audio production, it has been recommended as a supported Linux platform for Harrison Mixbus.

Buzztrax is a free software project to create a clone of the Buzz music composer. The driving motivation is to preserve the playability of the compositions made with Buzz. Songs are made by adding virtual sound generators and effects, connecting them, recording short musical phrases and arranging them in the sequencer. For distribution, songs can be exported to common audio formats such as OGG, MP3, WAV and many others.

Common Music Notation (CMN) is open-source musical notation software. It is written in Common Lisp and runs on a variety of operating systems and Common Lisp implementations.

Denemo is a scorewriter and music sequencer. Denemo has been under development since 1999.

FFmpeg is a free and open-source software project consisting of a large suite of libraries and programs for handling video, audio, and other multimedia files and streams. At its core is the FFmpeg program itself, designed for command-line-based processing of video and audio files. It is widely used for format transcoding, basic editing, video scaling, video post-production effects and standards compliance.

Frescobaldi is an editor for LilyPond music files. It aims to be powerful, yet lightweight and easy to use. Frescobaldi is free software, freely available under the GNU General Public License. It is designed to run on all major operating systems. It is named after Girolamo Frescobaldi, an Italian composer of keyboard music in the late Renaissance and early Baroque period.

Gregorio is a free and open-source scorewriter computer program especially for Gregorian chant in square notation. Gregorio was adopted by many Abbeys and large projects, the most prominent user is maybe the St. Peters's Abbey of Solesmes.

Hydrogen is an open source drum machine created by Alessandro Cominu, an Italian programmer who goes by the pseudonym Comix. Its main goal is to provide professional yet simple and intuitive pattern-based drum programming.

Impro-Visor is an educational tool for creating and playing a lead sheet, with a particular orientation toward representing jazz solos.

Integra Live is open-source software for interactive sound design developed and maintained by the Integra Lab at Birmingham Conservatoire, part of Birmingham City University. The software takes an audio input either from the computer's audio interface or from an audio file, and allows various types of audio transformation to be applied. The software can be used in live performance as well as in creating new sounds or composing new music in a studio. Integra Live was originally designed to address problems of software usability in the creation and performance of live electronic music. Integra Live is supported on PC computers running the Microsoft Windows operating system and on Apple computers running OS X.

Jokosher is a free software, non-linear multi-track digital audio editor, released under the GNU GPL. It is written in Python, using the GTK+ interface and GStreamer as an audio back-end, initially just for the Linux operating system but also with support for Windows.

Libav is a free software project, forked from FFmpeg in 2011, that produces libraries and programs for handling multimedia data.

LilyPond is a computer program and file format for music engraving. One of LilyPond's major goals is to produce scores that are engraved with traditional layout rules, reflecting the era when scores were engraved by hand.

LMMS is a digital audio workstation application program. When LMMS is executed on a computer with appropriate hardware, it allows music to be produced by arranging samples, synthesizing sounds, playing on a MIDI keyboard, and combining the features of trackers and sequencers. It supports the Linux Audio Developer's Simple Plugin API (LADSPA), LV2 and Virtual Studio Technology (VST) plug-ins. It is free software, written in Qt and released under the GNU General Public License, version 2 (GPLv2).

MilkDrop is a hardware-accelerated music visualization plugin for Winamp, which was originally developed by Ryan Geiss in 2001. It uses DirectX and intelligent beat detection to render iterated images which blend seamlessly. MilkDrop uses a complex system of interpolation to transition between presets gradually through time, creating a constantly changing visual experience.

MilkyTracker is a free software multi-platform music tracker for composing music in the MOD and XM module file formats.

Mixxx is free and open-source software for DJing. It is cross-platform and supports most common music file formats. Mixxx can be controlled with MIDI and HID controllers and timecode vinyl records in addition to computer keyboards and mice.

MPlayer is a free and open-source media player software application. It is available for Linux, OS X and Microsoft Windows. Versions for OS/2, Syllable, AmigaOS, MorphOS and AROS Research Operating System are also available. A port for DOS using DJGPP is also available. Versions for the Wii Homebrew Channel and Amazon Kindle have also been developed.

MusE is computer software, a sequencer for Musical Instrument Digital Interface (MIDI) and audio, with recording and editing abilities. It was originally written by Werner Schweer and now is developed by the MusE development team. It is free software released under the GNU General Public License.

MuseScore is a scorewriter for Windows, macOS, and Linux, comparable to Finale and Sibelius, supporting a wide variety of file formats and input methods. It is released as free and open-source software under the GNU General Public License. MuseScore is accompanied by a freemium mobile score viewer and playback app, and an online score sharing platform. The makers of MuseScore claim that it is the world's most popular notation software.

Psycle is a modular music production application for Microsoft Windows IBM PC-compatible computers. It is based on the tracker interface but also includes features like VST compatibility, 96 kHz / 32 bit wav rendering and ASIO support. Psycle songs are stored in .psy files although the software is able to import other popular tracker formats as well like .xm, .it and the original .mod extension files.

Qtractor is a hard disk recorder and digital audio workstation application for GNU/Linux. Qtractor is written in C++ and is based on the Qt framework. Its author is Rui Nuno Capela, who is also responsible for the Qjackctl, Qsynth and Qsampler line of GNU/Linux audio software. Qtractor's intention was to provide digital audio workstation software simple enough for the average home user, and yet powerful enough for the professional user.

Rosegarden is a free software digital audio workstation program developed for Linux with ALSA and Qt4. It acts as an audio and MIDI sequencer, scorewriter and musical composition and editing tool. It is intended to be a free alternative to such applications as Cubase.

Sonic Pi is a live coding environment based on Ruby, originally designed to support both computing and music lessons in schools, developed by Sam Aaron in the University of Cambridge Computer Laboratory in collaboration with Raspberry Pi Foundation.

Sweep is a Free and open-source digital audio editor and live playback tool for Unix-like systems such as Linux and Berkeley Software Distribution (BSD). It is able to handle many sound formats, including MP3, WAV and Vorbis. Originally developed with the support of Pixar, the most notable feature of Sweep is its stylus-like cursor tool called Scrubby.

TuxGuitar is a free and open-source tablature editor, which includes features such as tablature editing, score editing, and import and export of Guitar Pro gp3, gp4, and gp5 files. In addition, TuxGuitar's tablature and staff interfaces function as basic MIDI editors.

VCV Rack is a free and open-source cross-platform software modular synthesizer.