
The .22 Long Rifle or simply .22 LR is a long-established variety of .22 caliber rimfire ammunition originating from the United States. It is used in a wide range of rifles, pistols, revolvers, smoothbore shotguns, and submachine guns.

The ArmaLite AR-7 Explorer is a semi-automatic firearm in .22 Long Rifle caliber, developed in 1959 from the AR-5 that was adopted by the U.S. Air Force as a pilot and aircrew survival weapon. The AR-7 was adopted and modified by the Israeli Air Force as an aircrew survival weapon in the 1980s.

The Blüm machine gun was a Soviet training machine gun designed by Mikhail Nikolayevich Blüm around 1929. It was chambered for the .22 Long Rifle cartridge. The gun was developed in order to reduce the training costs in terms of ammunition and wear of the Soviet machine guns in service at the time.

The garrucha is a small pistol, similar to a derringer, common in southern Brazil and Argentina in the early 20th century. It is usually double-barreled, though with the barrels side-by-side rather than vertical as is common in American derringers, and the bores can be rifled or smooth.

High Standard Derringer was introduced by High Standard Manufacturing Company in 1962; it was a remarkable change to the over-under derringer design with innovative solutions.

The M6 Aircrew Survival Weapon was a specially-made .22 Hornet over .410 bore combination gun issued to United States Air Force aircrews to help forage for food in the event of a plane crash. It was issued from 1952 until the early 1970s, in conjunction with the M4 Survival Rifle. Plans to replace both with the ArmaLite AR-5 never came to fruition and in 2018 was instead replaced with the GAU-5A Aircrew Self Defense Weapon in some instances.

The Marble Game Getter is a light, double-barrel (over-under), combination gun manufactured by the Marble's Arms & Manufacturing Company in Gladstone, Michigan. The firearm features a skeleton folding stock and a rifle barrel over a smooth-bore shotgun barrel. A manually pivoted hammer striker is used to select the upper or lower barrel. Three generations of the system were/are produced—First Generation, Second Generation and the Third Generation currently manufactured by Marble Arms.

A pen gun is a firearm that resembles an ink pen. They generally are of small caliber and are single shot. Early examples of pen guns were pinfired, but modern designs are rim or centerfire. Some pen guns are not designed to fire regular cartridges, but rather blank cartridges, signal flares or tear gas cartridges.

The Savage Model 24 is an American made over-and-under combination gun manufactured by Savage Arms. The basic .22LR over .410 gauge model weighs 7 pounds, has 24-inch barrels and an overall length of 41-inches. It may also be disassembled for ease of stowage.

The Springfield Armory M6 Scout is a .22 Hornet over .410 bore combination gun that is virtually identical to the original M6 Aircrew Survival Weapon. It is also made in .22 Long Rifle over .410 bore and .22 Magnum over .410 bore. The Scouts are made with 18.25 inches (46.4 cm) barrels, as opposed to the original M6's 14 inches (36 cm) barrel length, to comply with National Firearms Act. The later models have large over-sized trigger guards and Picatinny rails for mounting a wide range of sights and scopes. They come in stainless steel or with a Parkerized finish.