
This is a list of characters in the American television series, Prison Break. The characters are listed alphabetically by their last name or by the name which appears in the episode credits.

Theodore "T-Bag" Bagwell is a fictional character from the American television series Prison Break. Played by Robert Knepper, he is part of the main group of characters in the series and is part of the Fox River Eight. After guest-starring in the series' second episode, "Allen", the actor became one of the regular cast members.

Bradley Bellick is a fictional character from the American television series, Prison Break. He is portrayed by Wade Williams. As one of the principal characters of Prison Break, he has been featured in the first four seasons of the series. The character was introduced in the series' pilot as Captain Brad Bellick, the leader of the correctional officers at Fox River State Penitentiary. Originally, he was the main antagonist of Michael Scofield and the escape team. In the second season, the character's role changes as the main plot moves away from the prison setting, which allows him to remain as one of the main characters in the series. While not possessing the educational rigour as Scofield or Agent Mahone, he has shown himself to be highly cunning and even been able to outsmart Scofield on numerous occasions and he must not be underestimated, and in Season 2 was able to track down several of the Fox River escapees and travel across America on a low budget. In season three, he is a prisoner in the Panamanian prison, Sona. In season four, Bellick became a member of Scofield's team dedicated to locating Scylla, but sacrificed his life to protect their mission.

Lincoln Burrows, played by Dominic Purcell, is a fictional character and one of the two protagonists of the American television series Prison Break. The plot of Prison Break revolves around Lincoln being framed for the murder of the Vice President's brother and Lincoln's brother, Michael Scofield’s plan to help him escape his death sentence. In flashbacks, teenage Lincoln is played by Max Kirsch, and for one episode, Hunter Jablonski.

Benjamin Miles "C-Note" Franklin, played by Rockmond Dunbar, is a fictional character from the American television series, Prison Break. The character was introduced as a prisoner in the pilot episode. The actor was promoted from a recurring guest star to a regular cast member midway through the first season.

Paul Kellerman, played by Paul Adelstein, is a fictional character from the American television series, Prison Break. The character was introduced to the series as a Secret Service special agent in the series pilot but the actor was not listed as a regular cast member until the third episode. The character's role is most prominent in the series' conspiracy plot.

This is a list of characters in the American television series, Prison Break. The characters are listed alphabetically by their last name or by the name which appears in the episode credits.

Alexander "Alex" Mahone is a fictional character portrayed by William Fichtner in the American television series Prison Break. Mahone is introduced in the premiere of the second season as a special agent in the Federal Bureau of Investigation, specializing in manhunts for escaped prisoners for 14 years.

Michael Scofield, portrayed by Wentworth Miller, is a fictional character and one of the two main protagonists of the American television series Prison Break. The character first appeared in the series pilot, in which he deliberately sends himself to prison so as to break his elder brother, Lincoln Burrows, out before his execution for a crime he did not commit. The storyline of the first season revolves around the two brothers and Michael's plan to help Lincoln escape his death sentence. Later seasons detail their life on the run and their quest for the truth behind Lincoln's imprisonment. As the principal character, Michael has been featured in every episode of the series. Although both Lincoln and Michael are the main protagonists of the series, Michael has been featured more extensively than Lincoln, especially in the first season and the third.

Fernando Sucre, played by Amaury Nolasco, is a fictional character from the American television series, Prison Break. He is introduced to the series in the pilot episode as the prison cellmate of the series protagonist, Michael Scofield quickly growing into a major character in the series.

Dr. Sara Scofield is a fictional character from the American television series, Prison Break. She is played by Sarah Wayne Callies.

This is a list of characters in the American television series, Prison Break. The characters are listed alphabetically by their last name or by the name which appears in the episode credits.