
Vaucluse is a department in the southeastern French region of Provence-Alpes-Côte d'Azur. It had a population of 559,016 as of 2016. The department's prefecture is Avignon.
Avignon Provence Airport is an airport located in the city of Avignon and 4 kilometres (2 mi) west of Caumont-sur-Durance, in the Vaucluse department of the Provence-Alpes-Côte d'Azur region in France.

The Battle of Arausio took place on 6 October 105 BC, at a site between the town of Arausio, and the Rhône River. Ranged against the migratory tribes of the Cimbri under Boiorix and the Teutoni under Teutobod were two Roman armies, commanded by the proconsul Quintus Servilius Caepio and consul Gnaeus Mallius Maximus. However, bitter differences between the commanders prevented the Roman armies from co-operating, with devastating results. The terrible defeat gave Gaius Marius the opportunity to come to the fore and make radical reforms to the organisation and the recruitment of Roman legions. Roman losses are described as being up to 80,000 troops as well as another 40,000 auxiliary troops (allies) and servants and camp followers, virtually all of their participants in the battle. In terms of losses, the battle is regarded as one of the worst defeats in the history of ancient Rome.

The Château de Beaumont le Vieux is a ruined castle in the commune of Beaumont-du-Ventoux in the Vaucluse département of France.

Sporting Union Cavaillonnais XIII are a French Rugby league club based in Cavaillon, Vaucluse in the Provence-Alpes-Côte d’Azur region. The club plays in the French National Division 1 which is the French rugby league's 3rd tier. Founded in 1938, their home games are played at the Stade Pagnetti.

The Jewish cemetery of L'Isle-sur-la-Sorgue is one of the important Jewish sites of the Department of Vaucluse. Since 30 June 2008 it is listed as a historic Monument.

The Comtat Venaissin, often called the Comtat for short, was a part of the Papal States (1274‒1791) in what is now the Provence-Alpes-Côte d'Azur region of France.

The Château d'Entrechaux is a ruined castle in the commune of Entrechaux in the Vaucluse département of France.
The Château de Lacoste or La Coste is a ruined castle in the commune of Lacoste in the Vaucluse département of France.

Air Base 115 Orange-Caritat is a French Air and Space Force base in Vaucluse, France. It is equipped with one runway and was named after Maurice de Seynes, a French-Soviet aircraft pilot. It is located 5 kilometres (3 mi) east of Orange, a commune in the Vaucluse department of the Provence-Alpes-Côte d'Azur region in France.
The ancient residential diocese of Orange in the Comtat Venaissin in Provence, a fief belonging to the Papacy, was suppressed by the French government during the French Revolution. It was revived in 2009 as a titular see of the Roman Catholic Church.

Saint-Gobain SEFPRO, founded in 1929, produces refractories for the glass industry. The company consists of plants, sales offices and Research and Development Centers employing over 2200 people across four continents, with headquarters in Le Pontet, Vaucluse, France. The group belongs to the ‘Innovative Materials’ division of the Saint-Gobain group.

The 3rd constituency of Vaucluse is a French legislative constituency in the Vaucluse département. Marion Maréchal-Le Pen, a member of the National Front, represented the constituency during the XIV legislature (2012–2017).