
Hafizullah Amin was an Afghan communist revolutionary, politician and teacher. He organized the Saur Revolution of 1978 and co-founded the Democratic Republic of Afghanistan (DRA), ruling Afghanistan as General Secretary of the People's Democratic Party from September 1979 until his assassination in December 1979.
On 5 August 2010, ten members of International Assistance Mission (IAM) Nuristan Eye Camp team were killed in Kuran wa Munjan District of Badakhshan Province in Afghanistan. The team was attacked as it was returning from Nuristan to Kabul. One team member was spared while the rest of the team were killed immediately. Those killed were six Americans, two Afghans, one Briton and one German.

Islam Bibi was a female police officer in Afghanistan in the Helmand province Headquarters and also a pioneer in the fight for feminism.

Dadullah was the Taliban's senior military commander in Afghanistan until his death in 2007. He was also known as Maulavi or Mullah Dadullah Akhund. He was an ethnic Pashtun from the Kakar tribe of Kandahar province. According to the United Nations' list of entities belonging to or associated with the Al-Qaida organization, he had been the Taliban's Minister of Construction. He was killed by British and American special forces.

Mullah Mansoor Dadullah (1972–2015) was Mullah Dadullah's younger half-brother who succeeded him as a senior military commander of the Taliban in southern Afghanistan. He came from the Arghandab district of Kandahar province, and belonged to the Kakar Pashtun tribe.

Adolph "Spike" Dubs was the United States Ambassador to Afghanistan from May 13, 1978, until his death in 1979. He was killed during a rescue attempt after his kidnapping.

Harold Joseph "Harry" Greene was a United States Army general who was killed during the War in Afghanistan. During his time with the United States Army, he held various commands associated with engineering and logistical support for United States and coalition troops. At the time of his death, he was deputy commanding general of Combined Security Transition Command – Afghanistan.

Nils Horner was a Swedish Radio journalist. Horner was the chief correspondent for Sveriges Radio's Asia division and had covered multiple stories surrounding the War in Afghanistan (2001–present), as well as natural disasters.

Mirwais Jalil, was an Afghan journalist for the BBC World Service near Kabul, Afghanistan. Jalil has been praised for being crucial in the BBC's coverage of the Afghanistan civil war and as a highly credible journalist. On 29 July 1994, he was returning from an interview with Prime Minister Gulbuddin Hekmatyar when masked men kidnapped him, and Jalil was found murdered the next morning outside of Kabul. Jalil's aggressive coverage of the civil war between the mujahedeen was seen as authoritative and is said to be the reason of his fate.

Malalai Kakar was the most high-profile policewoman in the Islamic Republic of Afghanistan (2001–2021) during its existence.

Ahmed Wali Karzai was a politician in Afghanistan who served as Chairman of the Kandahar Provincial Council from 2005 until his death. He was the younger paternal half-brother of former Afghan President Hamid Karzai and an elder of the Popalzai tribe. Wali Karzai formerly lived in the United States, where he managed a restaurant owned by his family. He returned to Afghanistan following the removal of the Taliban government in late 2001. He has been accused of political corruption and was allegedly on the CIA payroll. He was assassinated by one of his close bodyguards, Sardar Mohammad, on 12 July 2011.

Habibullah Khan was the Emir of Afghanistan from 1901 until his death in 1919. He was the eldest son of the Emir Abdur Rahman Khan, whom he succeeded by right of primogeniture in October 1901. His grandfather was Mohammad Afzal Khan.

Sardar Mohammed Daoud Khan, also romanized as Daud Khan or Dawood Khan, was an Afghan politician who served as the Prime Minister of Afghanistan from 1953 to 1963 and, as leader of the 1973 Afghan coup d'état which overthrew the monarchy, became the first President of Afghanistan, from 1973 to 1978. Born into the Musahiban royal family, Khan started as a provincial governor in the 1930s and later a commander before he was chosen as prime minister in the monarchy of his first cousin, Mohammed Zahir Shah. Ten years after his resignation as prime minister, Khan overthrew the monarchy with the backing of Afghan Army officers and declared himself as the first President of the Republic of Afghanistan in 1973, renouncing his royal title.

Thomas E. Little was an American optometrist from Kinderhook, New York, most widely known as the leader of an International Assistance Mission Nuristan Eye Camp team killed in the 2010 Badakhshan massacre. The team was attacked in the Kuran wa Munjan District of Badakhshan Province, while returning from Nuristan to Kabul.

Tetsu Nakamura , also known as Kaka Murad ,(15 September 1946 – 4 December 2019), was a Japanese physician and honorary Afghan citizen who headed Peace Japan Medical Services (PMS), an aid group known as Peshawar-kai in Japanese.

Haji Abdul Qadeer was a prominent Northern Alliance leader in Afghanistan and opposed the Taliban. Originally a commander of the Hezb-i Islami Khalis faction during the Soviet–Afghan War, he then served as governor of Nangarhar Province, the head of the Eastern Afghanistan Shura, and later Vice President of Afghanistan and Minister of Public Works in the administration of Hamid Karzai from 19 June 2002 until his assassination on 6 July 2002. He was the older brother of fellow anti-Soviet and Northern Alliance commander Abdul Haq, who was executed in late 2001 by the Taliban.

Abdul Samad Rohani was an Afghan journalist who worked for the British Broadcasting Corporation (BBC) and the Afghan news agency Pajhwok. He was abducted in Helmand Province, Afghanistan, on June 7, 2008, and found murdered the following day in Lashkar Gah. Reporters Without Borders stated that he had apparently been tortured and then shot three times.

Danish Siddiqui was an Indian photo-journalist based in Delhi, who used to lead the national Reuters Multimedia team. He received the 2018 Pulitzer Prize for Feature Photography, as part of the Reuters team, for documenting the Rohingya Refugee Crisis. In 2021, he was killed while covering a clash between Afghan security forces and Taliban forces near a border crossing with Pakistan.

Death of Karen Fischer and Christian Struwe is about two German journalists working for Deutsche Welle who were shot on 7 October 2006 in a tent they had pitched alongside a road near Baghlan in Afghanistan, while they were doing research for a freelance documentary. They were the first foreign journalists killed after the 2001 invasion in the War in Afghanistan

Patrick Daniel Tillman Jr. was an American professional football player in the National Football League (NFL) who left his sports career and enlisted in the United States Army in May 2002 in the aftermath of the September 11 attacks. His service in Iraq and Afghanistan, and subsequent death, were the subject of national attention when he was killed in action as a result of friendly fire.