
The Battle of Opis, fought in September 539 BC, was a major engagement between the armies of Persia under Cyrus the Great and the Neo-Babylonian Empire under Nabonidus during the Persian invasion of Mesopotamia. At the time, Babylonia was the last major power in western Asia that was not yet under Persian control. The battle was fought in or near the strategic riverside city of Opis, north of the capital Babylon. It resulted in a decisive victory for the Persians. A few days later, the city of Sippar surrendered to the Persians and Cyrus's forces entered Babylon apparently without a fight. Cyrus was subsequently proclaimed king of Babylonia and its subject territories, thus ending the independence of Babylon and incorporating the Babylonian Empire into the greater Persian Empire.

The Battle of Carchemish was fought about 605 BC between the armies of Egypt allied with the remnants of the army of the former Assyrian Empire against the armies of Babylonia, allied with the Medes, Persians, and Scythians. This battle is also mentioned in Ezekiel chapter 30 in the Bible.

The Medo-Babylonian conquest of the Assyrian Empire was the last war fought by the Neo-Assyrian Empire between 626 and 609 BC. Succeeding his brother Ashur-etil-ilani, the new king of Assyria, Sinsharishkun, was immediately faced by the revolt of one of his brother's chief generals, Sin-shumu-lishir, who attempted to usurp the throne for himself. Though this threat was dealt with relatively quickly, the instability caused by the brief civil war may have made it possible for another official or general, Nabopolassar, to rise up and seize power in Babylonia. Sinsharishkun's inability to defeat Nabopolassar, despite repeated attempts over the course of several years, allowed Nabopolassar to consolidate power and form the Neo-Babylonian Empire, restoring Babylonian independence after more than a century of Assyrian rule. The Neo-Babylonian Empire, and the newly formed Median Empire under King Cyaxares, then invaded the Assyrian heartland. In 614, the Medes captured and sacked Assur, the ceremonial and religious heart of the Assyrian Empire, and in 612 their combined armies attacked and razed Nineveh, the Assyrian capital. Sinsharishkun's fate is unknown but it is assumed that he died in the defense of his capital. He was succeeded as king only by Ashur-uballit II, possibly his son, who rallied what remained of the Assyrian army at the city of Harran and, bolstered by an alliance with Egypt, ruled for three years, in a last attempt to resist the Medo-Babylonian invasion of his realm.

The Battle of Nineveh is conventionally dated between 613 and 611 BC, with 612 BC being the most supported date. Rebelling against the Assyrians, an allied army which combined the forces of Medes and the Babylonians, besieged Nineveh and sacked 750 hectares of what was, at that time, one of the greatest cities in the world. The fall of Nineveh led to the destruction of the Neo-Assyrian Empire over the next three years as the dominant state in the Ancient Near East. Archeological records show that the capital of the once mighty Assyrian Empire was extensively de-urbanized and depopulated in the decades and centuries following the battle. A garbled account of the fall of the city later led to the story of the legendary king Sardanapalus.

The Siege of Babylon in 689 BC took place after Assyrian king Sennacherib's victory over the Elamites at the Battle of River Diyala. Although the Assyrians had suffered heavy casualties at the river, they had beaten the Elamites such that the Babylonians now stood alone.

In 589 BC, Nebuchadnezzar II laid siege to Jerusalem, culminating in the destruction of the city and its temple in the summer of 587 according to Albright, or 586 BC according to Thiele. In 2004, Rodger Young published an analysis in which he identified 587 BC for the end of the siege, based on details from the Bible and neo-Babylonian sources for related events. Whereas the Nebuchadnezzar Chronicle provides information about the siege of Jerusalem in 597 BC, the only known records of the siege that culminated in Jerusalem's destruction are found in the Hebrew Bible.

The siege of Jerusalem was a military campaign carried out by Nebuchadnezzar II, king of Babylon, in 597 BC. In 605 BC, he defeated Pharaoh Necho at the Battle of Carchemish, and subsequently invaded Judah. According to the Nebuchadnezzar Chronicle, King Jehoiakim of Judah rebelled against Babylonian rule, but Nebuchadnezzar captured the city and installed Zedekiah as ruler.

The Siege of Tyre was waged by Nebuchadnezzar II of Babylon for 13 years from 586 to 573 BC. The siege of Tyre, in Phoenicia, has a significant connection to the Book of Ezekiel where it was prophesied that the city would fall to Babylonian forces after a years-long siege.