
The Mark Twain Prize for American Humor is an American award presented by the John F. Kennedy Center for the Performing Arts annually since 1998. Named after the 19th-century humorist Mark Twain, it is presented to individuals who have "had an impact on American society in ways similar to" Twain. The JFK Center chose Twain due to his status as a controversial social commentator and his "uncompromising perspective of social injustice and personal folly." A copy of Karl Gerhardt's 1884 bust of Twain is presented in an autumn ceremony at the Kennedy Center Concert Hall in Washington, D.C., during which the honoree is celebrated by his or her peers. The event is a significant fundraiser to benefit the Kennedy Center, which sells tickets as well as access to dinners and after-parties featuring the celebrities.

Carol Creighton Burnett is an American actress, comedian, singer, and writer, whose career spans seven decades of television. She is best known for her groundbreaking comedy variety show, The Carol Burnett Show, originally aired on CBS. It was one of the first of its kind to be hosted by a woman. She has achieved success on stage, television and film in varying genres including dramatic and comedic roles. She has also appeared on various talk shows and as a panelist on game shows.

George Denis Patrick Carlin was an American stand-up comedian, actor, social critic, and author. Regarded as one of the most important and influential stand-up comics of all time, he was dubbed "the dean of counterculture comedians". He was known for his dark comedy and reflections on politics, the English language, psychology, religion, and taboo subjects. His "seven dirty words" routine was central to the 1978 United States Supreme Court case F.C.C. v. Pacifica Foundation, in which a 5–4 decision affirmed the government's power to censor indecent material on the public airwaves.

David Khari Webber Chappelle is an American stand-up comedian, actor, writer and producer. With his incisive observations, he has been described as "poetically unfiltered and sociopolitically introspective, with an ability to illuminate and interrogate agonizing and poignant topics." Chappelle is the recipient of numerous accolades, including four Emmy Awards and three Grammy Awards as well as the Mark Twain Prize. He is known for his satirical comedy sketch series Chappelle's Show (2003–2006). The series, co-written with Neal Brennan, ran until Chappelle quit the show in the middle of production of the third season. After leaving the show, Chappelle returned to performing stand-up comedy across the U.S. By 2006, Chappelle was called the "comic genius of America" by Esquire and, in 2013, "the best" by a Billboard writer. In 2017, Rolling Stone ranked him No. 9 in their "50 Best Stand Up Comics of All Time."

William Edward Crystal is an American actor, comedian, singer, writer, producer, director, and television host. He gained prominence in the 1970s and 1980s for television roles as Jodie Dallas on the ABC sitcom Soap and as a cast member and frequent host of Saturday Night Live. He then became a Hollywood film star during the late 1980s and 1990s, appearing in the critical and box office successes Rabbit Test (1978), The Princess Bride (1987), Throw Momma from the Train (1987), Memories of Me (1988), When Harry Met Sally... (1989), City Slickers (1991), Mr. Saturday Night (1992), Analyze This (1999), and Parental Guidance (2012). and providing the voice of Mike Wazowski in the Monsters, Inc. films, starting in 2001. He will reprise his role in the upcoming Disney+ series Monsters at Work (2021).

Ellen Lee DeGeneres is an American comedian, television host, actress, writer, and producer. She starred in the sitcom Ellen from 1994 to 1998 and has hosted her syndicated TV talk show, The Ellen DeGeneres Show, since 2003.

John William Ferrell is an American actor, comedian, producer, writer, and businessman. He first established himself in the mid-1990s as a cast member on the NBC sketch comedy show Saturday Night Live, and has subsequently starred in comedy films such as Anchorman: The Legend of Ron Burgundy (2004), Talladega Nights (2006), Step Brothers (2008), The Other Guys (2010), and Anchorman 2: The Legend Continues (2013), all but one of which he co-wrote with his comedy partner Adam McKay. The two also founded the comedy website Funny or Die in 2007. Other film roles include Elf, Old School, Blades of Glory (2007), Daddy's Home (2015), and the animated films Megamind (2010) and The Lego Movie (2014).

Elizabeth Stamatina "Tina" Fey is an American actress, comedian, writer, producer, and playwright. She is best known for her work on the NBC sketch comedy series Saturday Night Live (1997–2006) and for creating the comedy series 30 Rock and Unbreakable Kimmy Schmidt (2015–2020). Fey is also known for her work in film, including Mean Girls (2004), Baby Mama (2008), Date Night (2010), Megamind (2010), Muppets Most Wanted (2014), Sisters (2015), Whiskey Tango Foxtrot (2016), Wine Country (2019), and Soul (2020).

Caryn Elaine Johnson, known professionally as Whoopi Goldberg, is an American actor, comedian, author, and television personality. A recipient of numerous accolades, Goldberg is one of sixteen entertainers to have won an Emmy Award, a Grammy Award, an Academy Award, and a Tony Award.

James Douglas Muir "Jay" Leno is an American comedian, actor, writer, producer, and former late-night television host. After doing stand-up comedy for years, he became the host of NBC's The Tonight Show with Jay Leno from 1992 to 2009. Beginning in September 2009, Leno started a primetime talk show, titled The Jay Leno Show, which aired weeknights at 10:00pm ET, also on NBC.

David Michael Letterman is an American television host, comedian, writer, and producer. He hosted late night television talk shows for 33 years, beginning with the February 1, 1982, debut of Late Night with David Letterman on NBC, and ending with the May 20, 2015, broadcast of Late Show with David Letterman on CBS. In total, Letterman hosted 6,080 episodes of Late Night and Late Show, surpassing his friend and mentor Johnny Carson as the longest-serving late night talk show host in American television history. In 1996, Letterman was ranked 45th on TV Guide's 50 Greatest TV Stars of All Time. In 2002, The Late Show with David Letterman was ranked seventh on TV Guide's 50 Greatest TV Shows of All Time.

Stephen Glenn Martin is an American actor, comedian, writer, producer, and musician. Martin came to public notice in the 1960s as a writer for The Smothers Brothers Comedy Hour, and later as a frequent host on Saturday Night Live. In the 1970s, Martin performed his offbeat, absurdist comedy routines before packed houses on national tours. Since the 1980s, having branched away from comedy, Martin has become a successful actor, as well as an author, playwright, pianist, and banjo player, eventually earning Emmy, Grammy, and American Comedy awards, among other honors.

Lorne Michaels is a Canadian-American television producer and screenwriter best known for creating and producing Saturday Night Live and producing the Late Night series, The Kids in the Hall and The Tonight Show.

Edward Regan Murphy is an American actor, comedian, writer, and singer. He rose to fame on the sketch comedy show Saturday Night Live, for which he was a regular cast member from 1980 to 1984. Murphy has also worked as a stand-up comedian and was ranked No. 10 on Comedy Central's list of the 100 Greatest Stand-ups of All Time.

William James Murray is an American actor, comedian, and writer. Known for his deadpan delivery, he first rose to fame on Saturday Night Live, a series of performances that earned him his first Emmy Award, and later starred in comedy films—including Meatballs (1979), Caddyshack (1980), Stripes (1981), Tootsie (1982), Ghostbusters (1984), Ghostbusters II (1989), What About Bob? (1991), Groundhog Day (1993) and Kingpin (1996). His only director credit is Quick Change (1990), co-directed with Howard Franklin.

George Robert Newhart is an American stand-up comedian and actor, noted for his deadpan and slightly stammering delivery style. Newhart came to prominence in 1960 when his album of comedic monologues, The Button-Down Mind of Bob Newhart, became a bestseller and reached number one on the Billboard pop album chart; it remains the 20th-best selling comedy album in history. The follow-up album, The Button-Down Mind Strikes Back!, was also a success, and the two albums held the Billboard number one and number two spots simultaneously.

Richard Franklin Lennox Thomas Pryor was an American stand-up comedian, actor, and writer. He reached a broad audience with his trenchant observations and storytelling style, and is widely regarded as one of the greatest and most influential stand-up comedians of all time.

Carl Reiner was an American actor, comedian, director, screenwriter, and author whose career spanned seven decades. During the early years of television comedy from 1950 to 1957, he acted on and contributed sketch material for Your Show of Shows and Caesar's Hour, starring Sid Caesar. In the 1960s, Reiner was best known as the creator, producer, writer, and actor on The Dick Van Dyke Show.

Marvin Neil Simon was an American playwright, screenwriter and author. He wrote more than 30 plays and nearly the same number of movie screenplays, mostly adaptations of his plays. He has received more combined Oscar and Tony Award nominations than any other writer.

Mary Jean "Lily" Tomlin is an American actress, comedian, writer, singer, and producer. Tomlin started her career as a stand-up comedian as well as performing Off-Broadway during the 1960s. Her breakout role was on the variety show Rowan & Martin's Laugh-In from 1969 until 1973. She currently stars as Frankie Bergstein on the Netflix series Grace and Frankie, which debuted in 2015 and has earned her nominations for four Primetime Emmy Awards, three Screen Actors Guild Awards and a Golden Globe Award.

Jonathan Harshman Winters III was an American comedian, actor, author, television host, and artist. Beginning in 1960, Winters recorded many classic comedy albums for the Verve Records label. He also had records released every decade for over 50 years, receiving 11 Grammy nominations, including eight for Best Comedy Album, during his career. From these nominations, he won the Grammy Award for Best Album for Children for his contribution to an adaptation of The Little Prince in 1975 and the Grammy Award for Best Spoken Comedy Album for Crank(y) Calls in 1996.