
Melissa Aldana is a Chilean tenor saxophone player, who performs both as a soloist and with her band Melissa Aldana & Crash Trio.

Tomás Enrique Araya Díaz is a Chilean-American musician, best known as the vocalist and bassist of American thrash metal band Slayer. Araya is ranked fifty-eighth by Hit Parader on their list of the 100 Greatest Metal Vocalists of All Time.

Max Berrú Carrión was an Ecuadorian and Chilean musician. He was one of the two founders of Inti-Illimani where he was a lead singer between 1967 and 1997.

Andrés Bucci is a Chilean electronic music producer and DJ. He is known for his solo work as well as for his role as a member of Plan V. He is one of three Bucci brothers, all DJs and electronic music producers.

Pier Bucci is a Chilean electronic music producer. He is known for his solo work and for his role in the groups Mambotur, Skipsapiens, Monne Automne and Bucci. He is one of three Bucci brothers – Juan Pablo, Pier and Andrés – all of whom are electronic music producers.

Paula Schopf is a Chilean electronic music producer and DJ, born in Santiago, Chile in 1970. Sister of musician and producer Dandy Jack and DJ Adrian, she has developed her own career as a DJ and producer in both Chile and Germany under the name "Chica Paula".

Valeria Cisternas, better known by her stage name Tomasa Del Real, is a Chilean singer, composer, and reggaeton artist. She is regarded as a pioneer of Neoperreo, a social-media inspired offshoot of reggaeton. As such, many refer to her as "La Reina del Neoperreo".

Luis Enrique Gatica Silva, better known as Lucho Gatica was a Chilean bolero singer, film actor, and television host known as "the King of Bolero." It is estimated that Gatica released more than 90 recordings. He toured a vast portion of the world, having performed in concerts in Europe, the Middle East and Asia. He was the uncle of the record producer Humberto Gatica.

Luis "Checho" Orlando González Jiménez is a Chilean folklore composer and songwriter known mainly in his hometown. In the 1950s, he was a member of several musical trios, including "Los González", "Los Mantles" and "Los Mineros", and composed songs with Rubí Jáuregui. In the 2010 Copiapó mining accident he accompanied the relatives in the Esperanza camp. Through the record labels he created, he delivered "Dragones" and "Boyas" de Plata. These awards were also presented at the Festival of the Elderly held in 2003 with Checho's own funding.

Mario Antonio Iriarte Donoso is a Chilean musician, singer, songwriter and teacher, originary from Santa Cruz.

Nicolás Jaar is a Chilean-American composer and recording artist based in New York. Among his notable works are the albums Space Is Only Noise (2011), Pomegranates (2015) and Sirens (2016). Since 2011, he has embarked on multiple explorative directions, performing a five-hour improvisational concert at MoMA PS1 and releasing a large volume of experimental recordings through his label, Other People, including works by Lydia Lunch, Pierre Bastien, John Wall and Lucretia Dalt. He scored Jacques Audiard's Dheepan and Pablo Larrain's 2020 film, Ema. Jaar is half of the band Darkside and has released two albums under the alias Against All Logic.

Fernando José Larraín de Toro is a Chilean comedian and film/television actor. He is of Basque descent.

Javiera Alejandra Mena Carrasco is a Chilean indie electropop musician. She started her musical career in the Chilean indie music scene in 2001, and achieved wider success after the release of her first studio album in 2006. Her musical style tends to be synthesized electronic sound, although prior to her official debut she made acoustic-oriented songs accompanied solely by guitar.

Leopoldo Jorge Méndez Alcayaga is a Chilean-Swedish DJ, singer and producer, known by his stage name Méndez, formerly DJ Méndez. He won the 2002 MTV Video Music Awards Latinoamérica for Best Southwest New Artist.

Yael Meyer is a Los Angeles-based singer, songwriter, musician and producer.
Denisse Lillian Laval Soza, better known by her stage name Nicole, is a Chilean singer-songwriter, based in Santiago and Miami.

Juana (Juanita) Parra is the daughter of Gabriel Parra, and Eugenia Correa. Gabriel was the original drummer of Chilean progressive rock–folk group Los Jaivas. He died in a crash in Peru in 1988.

Francisco Ismael Segundo Parraguez Cabezas, or simply Ismael Parraguez was a Chilean musician, Normal teacher, poet, and novelist. He was known for being the creator of the Orfeón Chileno in 1914, during the centennial of the Battle of Rancagua and the children's poem Los pollitos dicen, which he published on his 1907 book Poesías Infantiles. Parraguez was also known by the pseudonym of Misael Guerra.

Jorge Arnaldo Pedreros Avilés was a Chilean musician, record producer, actor and comedian. He was one of the creators of the iconic comedy show Jappening con Ja.

Jonathan Alejandro Perez is a Chilean drummer who is currently based in Kristiansand, Norway. He is known for his work with the Norwegian gothic metal and symphonic metal bands Trail of Tears and Sirenia. He is currently Green Carnation drummer since 2016.

José Miguel Carlos Piñera Echenique, known in Chile by his nickname "Negro" Piñera is a Chilean celebrity, night club owner and amateur musician. He is the brother of President of Chile Sebastián Piñera and of economist José Piñera. Piñera was married to Argentinean model Belén Hidalgo. Negro Piñera is of Asturian and Basque descent.

Luis Mauricio Redolés Bustos is a Chilean poet, singer-songwriter and musician. His literary and musical work is characterised by irony, satire, humour and use of colloquialisms.

Claudio Valenzuela is a guitarist, singer, and composer. He is most known as the lead-singer and guitarist of Chilean rock band Lucybell. Formed in 1991, Valenzuela is the only original member and the main composer of the band, as the line-up shifted over the years. Lucybell has released 7 studio albums.