Enrique Milton Almada Cavo, also known as Quique Almada, was a Uruguayan actor and comedian.

Alberto Candeau was a famous Uruguayan actor and writer.

Daniel Hendler is a Uruguayan film, television, and theatre actor who works mainly in the cinema of Argentina, where he lives. He is known for his starring roles in films such as Bottom of the Sea, Family Law, The Paranoids, Phase 7 and award-winning Lost Embrace by director Daniel Burman, with whom he worked many times. Working on both sides of the Río de la Plata, Hendler achieved international recognition due to his awards as an actor. In 2004, he won the Silver Bear for Best Actor at the Berlin Film Festival for his performance in Lost Embrace. He made his debut as screenwriter and director with the film Norberto's Deadline in 2010. Hendler is part of the generation of actors who revitalized the Uruguayan cinema with films like 25 Watts, and is one of the regular actors of the so-called New Argentine Cinema.

George Hilton, born Jorge Hill Acosta y Lara, was an Uruguayan actor well known for his many Spaghetti Western performances. Sometimes credited as Jorge Hilton, he appeared in over 20 Euro-westerns as well as several Giallo and action films.
Rubens Osvaldo Jesús Udaquiola Laport is a Uruguayan-Argentine actor and UNHCR Goodwill Ambassador. In 2000, he earned Martín Fierro Award for his portrayal in television comedy Campeones de la Vida.

Gustavo Rojo Pinto was a Uruguayan film actor and producer. He appeared in more than 160 films and television shows between 1938 and 2016. He is the father of Ana Patricia Rojo.

Edmundo Rey Kelly was an Uruguayan film, stage and television actor during the country's Golden Age of film.

Omar Varela is a Uruguayan actor, director, playwright, and teacher, the founder of the theater company Italia Fausta.
Martín Pedro Zabalúa Marramoti, known as Tincho Zabala was a Uruguayan film actor.