
Alberto Candeau was a famous Uruguayan actor and writer.

Mateo Chiarino is a Uruguayan actor, writer, and director of film, stage, and television. He is currently based in Buenos Aires, Argentina.

Daniel Hendler is a Uruguayan film, television, and theatre actor who works mainly in the cinema of Argentina, where he lives. He is known for his starring roles in films such as Bottom of the Sea, Family Law, The Paranoids, Phase 7 and award-winning Lost Embrace by director Daniel Burman, with whom he worked many times. Working on both sides of the Río de la Plata, Hendler achieved international recognition due to his awards as an actor. In 2004, he won the Silver Bear for Best Actor at the Berlin Film Festival for his performance in Lost Embrace. He made his debut as screenwriter and director with the film Norberto's Deadline in 2010. Hendler is part of the generation of actors who revitalized the Uruguayan cinema with films like 25 Watts, and is one of the regular actors of the so-called New Argentine Cinema.

Juan Carlos Mareco was a Uruguayan actor and radio and television talk show host. He achieved fame in Spain, Chile and Argentina from the 1960s onwards in comedy roles and as a television host in a variety of genres.

Cecilio Pablo Fernando Podestá was a Uruguayan-Argentine stage actor, singer, acrobat, sculptor and painter. He is considered to be one of the most prominent actors of classical Argentina theatre, and along with his brothers, was one of the founders of the Circo criollo. A number of institutions and places are named after him, including a town in Buenos Aires Province, and film awards known as the Premios Pablo Podestá.

Edmundo Rey Kelly was an Uruguayan film, stage and television actor during the country's Golden Age of film.

Froilán Varela (1891–1948) was a Uruguayan stage and film actor. He spent most of his life in Argentina, where he appeared in twenty two films including the historical Savage Pampas (1945) for which he won the Silver Condor Award for Best Supporting Actor.

Omar Varela is a Uruguayan actor, director, playwright, and teacher, the founder of the theater company Italia Fausta.

Walter Vidarte was a Uruguayan actor.