
The ITUC Regional Organisation for Africa (ITUC-Africa) is a regional organisation of the International Trade Union Confederation, representing trade unions from countries in Africa. There are 56 national trade union federations affiliated to ITUC-Africa, from 45 countries, and representing a total of 15 million workers.

The Botswana Federation of Trade Unions (BFTU) is the national trade union federation for Botswana. Founded in 1977, it represents over 90% of all trade unions in the country, including all major unions. The BFTU is currently undertaking a reorganization which will see its 25 affiliates merged and reduced in numbers to 13.

The Central Organization of Trade Unions (COTU) is a national trade union center in Kenya. It was founded in 1965 upon the dissolution on the Kenya Federation of Labour and the African Workers' Congress. It currently closely liaises with Non Governmental Organizations of East Africa Trade Union (NGOEATU).

The Democratic Confederation of Labour (CDT) is a national trade union center in Morocco. It was established in 1978.

The Democratic Federation of Labour (FDT) is a national trade union center in Morocco. It was formed in April 2003 as a breakaway from the Democratic Confederation of Labour (CDT).

The Democratic Organization of African Workers' Trade Union was a regional organisation of the World Confederation of Labour. It has a membership of 35 unions and eight 'pan-African federations' in 29 countries.

The General Union of Algerian Workers is the main Algerian trade union, established February 24, 1956 with the objective of mobilizing Algerian labour against French colonial and capitalist interests. It was banned shortly afterwards, in May 1956.

The General Union of Moroccan Workers (UGTM) is a national trade union center in Morocco. It was formed March 20, 1960 and has a membership of 695,000.

The National Confederation of Senegalese Workers (CNTS) is a national trade union center in Senegal, It was founded in 1969 and has a membership of 60,000.

The National Confederation of Togolese Workers (CNTT) is a national trade union center in Togo. It was created in January, 1973 and included the Union Nationale des Travailleurs du Togo (UNTT) and the Confédération Syndicale des Travailleurs du Togo (CSTT), both of whom had been dissolved by the government in 1972.

The National Confederation of Workers of Burkina (CNTB) is a trade union centre in Burkina Faso. It is affiliated with the International Trade Union Confederation. CNTB emerged from the Confédération africaine des travailleurs croyants.

The National Organization of Trade Unions (NOTU) is the largest national trade union center in Uganda with 25 affiliated unions representing 935,000 workers in 2018.

The National Union of Namibian Workers (NUNW) is the national trade union center in Namibia. It was originally established as a general workers union in April 1970 through a resolution of the 1969/70 South West Africa People's Organisation (SWAPO) party congress in Tanzania. In 1978, the NUNW affiliated to the World Federation of Trade Unions (WTFU). The headquarters in exile of the NUNW were set up in Luanda, Angola in 1979. From 1986, various industrial unions were established inside Namibia under the umbrella of the NUNW and in 1989, a consolidation congress took place that merged the exiled and internal wings of the NUNW into a unified federation. In October 2009 the NUNW affiliated to the International Trade Union Confederation (ITUC), thus effectively withdrawing from the WFTU. In January 2014, NUNW affirmed its allegiance to SWAPO, citing both a shared experience during colonialism and SWAPO's political positions.

The Swaziland Federation of Trade Unions (SFTU) was a national trade union center in Swaziland. It was founded in 1983 and dissolved into the Trade Union Congress of Eswatini (TUCOSWA) in 2012.

The Trade Union Congress of Tanzania (TUCTA) is a national trade union center in Tanzania. It has a membership of 320,000 and was formed in 2000 after the dissolution of the Tanzania Federation of Free Trade Unions (TFTU).

The Tunisian General Labour Union is a national trade union center in Tunisia. It has a membership of more than one million and was founded January 20, 1946.

Zambia Union of Financial Institutions and Allied Workers (ZUFIAW) is the dominant financial trade union in Zambia.