
This is a list of science fiction comedy works—those mixing soft science fiction or science fantasy with comedy.

17776 is a serialized speculative fiction multimedia narrative by Jon Bois, published online through SB Nation. Set in the distant future in which all humans have become immortal and infertile, the series follows three sentient space probes that watch humanity play an evolved form of American football in which games can be played for millennia over distances of thousands of miles. The series debuted on July 5, 2017, and new chapters were published daily until the series concluded with its twenty-fifth chapter on July 15.

Agents of Mayhem is an open world action-adventure video game developed by Volition and published by Deep Silver. The game was released in August 2017 for Microsoft Windows, PlayStation 4, and Xbox One. The game's themes are based on Saturday-morning cartoons and superhero films. It is set in the same fictional universe as Volition's Saints Row series, and includes several plot and character crossovers. Agents of Mayhem received mixed reviews; it was generally praised for its humor, characters and combat but criticized for its repetitiveness.

Blackhole, stylized as BLACKHOLE, is a puzzle-platform game developed and published by independent Czech company FiolaSoft Studio. The developers worked with Let's Players and YouTubers on the script for the story and for building the characters. It was first released on February 27, 2015 for Microsoft Windows, followed by Linux and OS X on May 11, 2015.

The Cyberiad is a series of humorous science fiction short stories by Polish writer Stanisław Lem, originally published in 1965, with an English translation appearing in 1974. The main protagonists of the series are Trurl and Klapaucius, the "constructors".

Doctor Who: The Curse of Fatal Death is a Doctor Who special made specifically for the Red Nose Day charity telethon in the United Kingdom, and was originally broadcast in four parts on BBC One on 12 March 1999 under the title Doctor Who and the Curse of Fatal Death. Later home video releases are formatted as two parts and drop the "and" in the title. It follows in a long tradition of popular British television programmes producing short, light-hearted specials for such telethon events.

Dr. Slump is a Japanese manga series written and illustrated by Akira Toriyama. It was serialized in Shueisha's anthology magazine Weekly Shōnen Jump from 1980 to 1984, with the chapters collected into 18 tankōbon volumes. The series follows the humorous adventures of the little girl robot Arale Norimaki, her creator Senbei Norimaki, and the other residents of the bizarre Penguin Village.

EarthBound is a role-playing video game developed by Ape Inc. and HAL Laboratory and published by Nintendo for the Super Nintendo Entertainment System. The second entry in the Mother series, it was first released in Japan in August 1994, and in North America in June 1995. As Ness and his party of four, Paula, Jeff and Poo, the player travels the world to collect melodies from eight Sanctuaries in order to defeat the universal cosmic destroyer Giygas.

Everything You Know Is Wrong is the eighth comedy album by the Firesign Theatre. Released in October 1974 on Columbia Records, it satirizes UFO conspiracy theories and New Age paranormal beliefs such as Erich von Däniken's Chariots of the Gods and claimed psychic Uri Geller, which achieved wide public attention by that time.

Fables for Robots is a series of humorous science fiction short stories by Polish writer Stanisław Lem, first printed in 1964.

Fist of the North Star: Lost Paradise is an action role-playing video game developed and published by Sega for the PlayStation 4. It is based on the manga franchise Fist of the North Star by Buronson and Tetsuo Hara, and features the gameplay and mechanics of Sega's Yakuza game series. It was released in Japan on March 8, 2018 and worldwide on October 2, 2018.

Give Me Immortality or Give Me Death is a comedy album by the Firesign Theatre that was released in 1998 on Rhino Records. Its main theme satirizes 1990s radio formats and public hysteria over the Y2K programming bug. Give Me Immortality... is the first of the Firesign Theatre's Millenium CD trilogy We're Doomed, which includes Boom Dot Bust and Bride of Firesign.

The Honey, I Shrunk the Kids franchise consists of a series of American family-science fiction-comedy film and a television adaptation, based on a concept created by Stuart Gordon and Brian Yuzna, and an original story co-written by Gordon, Yuzna, and Ed Naha. Following the release of Honey, I Shrunk the Kids (1989), and its subsequent financial and critical success, two sequels and a television series followed; titled Honey, I Blew Up the Kid (1992), Honey, We Shrunk Ourselves (1997), and Honey, I Shrunk the Kids: The TV Show, respectively. A fourth sequel titled Shrunk entered development in 2019.

How Time Flys is a comedy album written by David Ossman and featuring the voice talents of all four members of The Firesign Theatre plus several other contributors. It was originally released by Columbia Records in 1973.

Hyper Police is a Japanese manga series and written and illustrated by Minoru Tachikawa. It is set in a period in the far future, in which humanity is almost extinct and most of the population are monsters. The series mostly follows the offices of a private police company and focuses on the life of Natsuki Sasahara, a young catgirl, and her co-workers: foxgirl Sakura Bokuseiinmonzeninari, werewolf Batanen Fujioka and his cousin Tomy Fujioka.

I Think We're All Bozos on This Bus is the fourth comedy album made by the Firesign Theatre for Columbia Records, released in August 1971. In addition to standard stereo formats, the album was released as a Quadraphonic LP and Quadraphonic 8-Track. It was nominated for a Hugo Award for Best Dramatic Presentation in 1972 by the World Science Fiction Society.

Tek Jansen is a fictional character featured on The Colbert Report and in a comic book series published by Oni Press. Jansen originated as a recurring joke in the form of a supposed self-published science fiction novel on the Report, reportedly as a parody of Bill O'Reilly's 1998 novel, Those Who Trespass. The character later appeared on the show in a series of animated shorts entitled Stephen Colbert Presents Stephen Colbert's Alpha Squad 7: A Tek Jansen Adventure, with Jansen voiced by Stephen Colbert, and in 2007 became the protagonist of a five-part comic series.

Journey to the Savage Planet is a 2020 adventure game developed by Typhoon Studios and published by 505 Games. It was released for Microsoft Windows, PlayStation 4, and Xbox One on January 28, 2020, followed by a Nintendo Switch port on May 21, 2020, and a Stadia version on February 1, 2021.

Mother 3 is a role-playing video game developed by Brownie Brown and HAL Laboratory and published by Nintendo for the Game Boy Advance. The final entry in the Mother series, it was released in Japan on April 20, 2006. The game follows Lucas, a young boy with psychic abilities, and a party of characters as they attempt to prevent a mysterious invading army from corrupting and destroying the world.

Nebulous is a post-apocalyptic science fiction comedy radio show written by Graham Duff and produced by Ted Dowd from Baby Cow Productions; it is directed by Nicholas Briggs. The series premiered in the United Kingdom on BBC Radio 4. Set in the year 2099 AD, the show focuses on the adventures of the eponymous Professor Nebulous, director of operations for the eco-troubleshooting team KENT (the Key Environmental Non-Judgmental Taskforce) as they combat various catastrophes and try to set the world back on the right path following a worldwide environmental disaster known as "The Withering". As well as being a parody of a number of famous science fiction programmes, including Doctor Who, Quatermass and Doomwatch, Nebulous is considered a cult radio programme, attracting a number of guest appearances from famous actors.

Not Insane or Anything You Want To is the sixth album released by the Firesign Theatre on Columbia Records. It was released in October 1972 and includes some material that was recorded in the studio as well as some material that was recorded before a live audience. The full title is listed on the spine of the record album as Not Insane or Anything You Want To. The abbreviated title Not Insane appears on the front of the album cover, while Or Anything You Want To appears on the back cover. It is usually referred to simply as Not Insane.

Rex Nebular and the Cosmic Gender Bender is a point-and-click graphic adventure game developed and published by MicroProse in November of 1992. The game is the first graphical adventure game developed by MicroProse. It was developed using the MicroProse Adventure Development system, and made use of 256-colour graphics. Tommo purchased the rights to this game and digitally publishes it through its Retroism brand in 2015.

Saints Row IV is a 2013 action-adventure game developed by Volition and published by Deep Silver. It is the sequel to 2011's Saints Row: The Third and the fourth installment in the Saints Row series. The game was released in August 2013 for Microsoft Windows, PlayStation 3, and Xbox 360, and was later ported to PlayStation 4, Xbox One, and Linux in 2015. A Nintendo Switch port was released on March 27, 2020.

Saints Row: Gat Out of Hell is a 2015 action-adventure game developed by Volition and High Voltage Software, published by Deep Silver and distributed by Square Enix in North America. It was released for Microsoft Windows, Linux, PlayStation 3, PlayStation 4, Xbox 360, and Xbox One. The PlayStation 3 and Xbox 360 versions of the game were released both physically and digitally; so were the PlayStation 4 and Xbox One versions, although the latter two also saw a release bundled alongside Saints Row IV: Re-Elected.

The Sims 3: Into the Future is the eleventh and final expansion pack for The Sims 3 series from Electronic Arts and was released on October 22, 2013, in North America. It is available for both Windows and OS X. In Europe, it was released on October 24, 2013, and in the United Kingdom on October 25, 2013.

The Space Bar is a 1997 graphic adventure game developed by Boffo Games and published by Rocket Science Games and SegaSoft. A comic science fiction story, it follows detective Alias Node as he searches for a shapeshifting killer inside The Thirsty Tentacle, a fantastical bar on the planet Armpit VI. The player assumes the role of Alias and uses his Empathy Telepathy power to live out the memories of eight of the bar's patrons, including an immobile plant, an insect with compound eyes and a blind alien who navigates by sound. Gameplay is nonlinear and under a time limit: the player may solve puzzles and gather clues in any order, but must win before the killer escapes the bar.

Space Brothers is a Japanese manga series written and illustrated by Chūya Koyama. It has been serialized in Kodansha's seinen manga magazine Morning since December 2007. A 99-episode anime television series adaptation by A-1 Pictures aired in Japan from April 2012 to March 2014. The manga was also adapted into a live-action film that premiered in May 2012. An anime film, Space Brothers #0, premiered in August 2014, titled. In 2011, Space Brothers won the general category at both, the 56th Shogakukan Manga Award and the 35th Kodansha Manga Award.

Space Quest is a series of six comic science fiction adventure games released between 1986 and 1995. The games follow the adventures of a hapless janitor named Roger Wilco as he campaigns through the galaxy for "truth, justice and really clean floors".

SpongeBob HeroPants is a 2015 action-adventure video game based on the animated movie The SpongeBob Movie: Sponge Out of Water. It was released on February 3, 2015 in North America and on March 26, 2015 in Europe for the Nintendo 3DS, PlayStation Vita, and Xbox 360. The game was developed by Behaviour Santiago and published by Activision.

The Star Diaries is a series of short stories of the adventures of space traveller Ijon Tichy, of satirical nature, by Polish writer Stanisław Lem. The first ones were published in a 1954 collection Sezam i inne opowiadania and first published as a separate book in 1957 titled Dzienniki gwiazdowe, expanded in 1971. Closely related to this series is the series Ze wspomnień Ijona Tichego [From the Memoirs of Ijon Tichy]. Usually these stories, and several others, are considered to be the same cycle of the adventures of Ijon Tichy.

Professor Tarantoga, an eccentric xenozoologist, traveller, and inventor, is a fictional character from science fiction works, mostly humorous, by Polish writer Stanislaw Lem.
TimeSplitters 2 is a first-person shooter video game developed by Free Radical Design and published by Eidos Interactive for PlayStation 2, GameCube and Xbox game consoles. It is the second game in the TimeSplitters series, and a sequel to the original TimeSplitters.

"Treehouse of Horror XVI" is the fourth episode of the seventeenth season of the American animated television series, The Simpsons. It first aired on the Fox network in the United States on November 6, 2005. In the sixteenth annual Treehouse of Horror, the Simpsons replace Bart with a robot son after Bart falls into a coma, Homer and various other male characters find themselves on a reality show where Mr. Burns hunts humans for sport, and costumed Springfieldians become whatever they are wearing, thanks to a witch who was disqualified from a Halloween costume contest. It was written by Marc Wilmore and directed by David Silverman. Terry Bradshaw and Dennis Rodman guest star as themselves. Around 11.63 million Americans tuned in to watch the episode during its original broadcast.

Under the Skin, known in Japan as Meiwaku Seijin: Panikku Mēkā, is an action-adventure video game by Capcom. It was developed by the company's Production Studio 4, and released in 2004 for the PlayStation 2. Containing science fiction and comedy elements, the main character of the game's story is an extraterrestrial named Cosmi, sent from Planet Mischief to Earth to generally wreak havoc. The game features cameos from some of the cast of one of Capcom's other games, such as an entire level that functions as a parody of Resident Evil 3: Nemesis.