
The Four Horsemen of the Apocalypse and the derived term Four Horsemen have appeared many times in popular culture.

Die Apokalyptischen Reiter is a Weimar, Germany based heavy metal band signed to Nuclear Blast in Europe and The End Records in North America.

The Binding of Isaac is an indie roguelike video game designed by Edmund McMillen and Florian Himsl, initially released in 2011 for Microsoft Windows; the game was later ported for OS X, and Linux operating systems. The game's title and plot are inspired by the Biblical story of the Binding of Isaac. In the game, Isaac's mother receives a message from God demanding the life of her son as proof of her faith, and Isaac, fearing for his life, flees into the monster-filled basement of their home where he must fight to survive. Players control Isaac or one of eleven other unlockable characters through a procedurally generated dungeon in a roguelike manner, fashioned after those of The Legend of Zelda, defeating monsters in real-time combat while collecting items and power-ups to defeat bosses and eventually Isaac's mother.

The Binding of Isaac: Rebirth is an indie roguelike video game designed by Edmund McMillen and developed and published by Nicalis. Rebirth was released for Microsoft Windows, OS X, Linux, PlayStation 4, and PlayStation Vita in November 2014, and for Xbox One, New Nintendo 3DS, and Wii U in July 2015. After an initial rejection due to its controversial content, Nicalis released Rebirth on iOS on January 11, 2017. A version for the Nintendo Switch was released on March 17, 2017.

Darksiders is a hack and slash action-adventure video game developed by Vigil Games and published by THQ. The game’s inspiration is from the Four Horsemen of the Apocalypse, with the player taking the role of the horseman War. The game was released for the PlayStation 3 and Xbox 360 on January 5, 2010 in North America, January 7 in Australia, January 8 in Europe, and March 18 in Japan. The Microsoft Windows version was released in North America and Australia on September 23, and in Europe on September 24. A parallel sequel, Darksiders II, was released on August 14, 2012.

Darksiders Genesis is a top-down hack and slash action role-playing video game developed by American studio Airship Syndicate and published by THQ Nordic. The game was released for Stadia and Microsoft Windows on December 5, 2019, and was released on the Nintendo Switch, PlayStation 4, and Xbox One on February 14, 2020. It is considered a spin-off prequel game in the Darksiders series and introduces the fourth Horseman of the Apocalypse, Strife, as the protagonist. Strife can also team up with his brother, War. Upon release, the game received positive reviews, with many reviewers praising the combat.

Darksiders II is an action role-playing hack and slash action-adventure video game developed by Vigil Games and published by THQ. It is the sequel to Darksiders and was released in August 2012 for Microsoft Windows, PlayStation 3, Xbox 360 and as a launch title for Wii U upon the console's Australian, European, and North American release in November 2012. The story follows the efforts of player character Death to clear the name of his brother, War, who stands accused of wiping out humanity.

Darksiders III is a video game developed by Gunfire Games and published by THQ Nordic for Microsoft Windows, PlayStation 4 and Xbox One in 2018. It is a sequel to Darksiders II and the third entry in the Darksiders series.

The 4 Horsemen of the Apocalypse is a 1962 American drama film directed by Vincente Minnelli and starring Glenn Ford, Ingrid Thulin, Charles Boyer, Lee J. Cobb, Paul Lukas, Yvette Mimieux, Karl Boehm and Paul Henreid. It is loosely based on the 1916 novel by Vicente Blasco Ibáñez, which had been filmed in 1921 with Rudolph Valentino. Unlike the first film, this was a critical and commercial disaster, which contributed greatly to the financial problems of MGM.

The Four Horsemen of the Apocalypse is a 1921 American silent epic war film produced by Metro Pictures Corporation and directed by Rex Ingram. Based on the 1916 Spanish novel The Four Horsemen of the Apocalypse by Vicente Blasco Ibáñez, it was adapted for the screen by June Mathis. The film stars Pomeroy Cannon, Josef Swickard, Bridgetta Clark, Rudolph Valentino, Wallace Beery, and Alice Terry.

Good Omens: The Nice and Accurate Prophecies of Agnes Nutter, Witch (1990) is a World Fantasy Award-nominated novel written as a collaboration between the English authors Terry Pratchett and Neil Gaiman.

Good Omens is a fantasy miniseries based on the 1990 novel of the same name by Terry Pratchett and Neil Gaiman. A co-production between Amazon Studios and BBC Studios, the six-episode series was created and written by Gaiman, who also served as showrunner. Douglas Mackinnon directed the series. Good Omens stars an ensemble cast led by David Tennant, Michael Sheen, Adria Arjona, Miranda Richardson, Michael McKean, Jack Whitehall, Jon Hamm, and Frances McDormand as the voice of God.

X-Men: Apocalypse is a 2016 American superhero film directed and produced by Bryan Singer and written by Simon Kinberg from a story by Singer, Kinberg, Michael Dougherty, and Dan Harris. The film is based on the fictional X-Men characters that appear in Marvel Comics and is the ninth installment in the X-Men film series. It is the sequel to X-Men: Days of Future Past (2014) and stars James McAvoy, Michael Fassbender, Jennifer Lawrence, Oscar Isaac, Nicholas Hoult, Rose Byrne, Tye Sheridan, Sophie Turner, Olivia Munn, and Lucas Till. In the film, the ancient mutant En Sabah Nur / Apocalypse is inadvertently revived in 1983, and plans to wipe out the modern civilization and take over the world, leading the X-Men to try to stop him and defeat his team of mutants.