
The United States Deputy Secretary of the Treasury, in the United States government, advises and assists the Secretary of the Treasury in the supervision and direction of the Department of the Treasury and its activities, and succeeds the Secretary in the secretary's absence, sickness, or unavailability. The Deputy Secretary plays a primary role in the formulation and execution of Treasury policies and programs in all aspects of the Department's activities. In addition, the Deputy Secretary is the only official other than the secretary who can sign a Treasury order, which is a document that delegates authority residing in the secretary or Deputy Secretary to another Treasury official, establishes Treasury policy, and establishes the reporting relationships and supervision of officials. Former Deputy Secretaries include Roger Altman, Lawrence Summers, Stuart E. Eizenstat, Kenneth W. Dam, and Samuel Bodman.

Adewale "Wally" Adeyemo is a Nigerian-American government official serving as the United States deputy secretary of the treasury. He was the first president of the Obama Foundation and also served during the Obama administration as the deputy national security advisor for international economics from 2015 to 2016 and deputy director of the National Economic Council.

Samuel Wright Bodman III was an American businessman, engineer, and politician who served as the 11th United States Secretary of Energy during the George W. Bush administration, from 2005 to 2009. He was also, at different times, the Deputy Secretary of the Treasury and the Deputy Secretary of Commerce.

Kenneth W. Dam served as Deputy Secretary of the Treasury from 2001 to 2004, where he specialized in international economic development. He is currently a senior fellow of the Brookings Institution and a professor emeritus and senior lecturer at the University of Chicago Law School.

Richard Gordon "Dick" Darman was an American businessman and government official who served in senior positions during the presidencies of Ronald Reagan and George H. W. Bush.

Stuart Elliott Eizenstat is an American diplomat and attorney. He served as the United States Ambassador to the European Union from 1993 to 1996 and as the United States Deputy Secretary of the Treasury from 1999 to 2001. For many years, and currently he has served as a partner and Senior Counsel at the Washington, D.C.–based law firm Covington & Burling and as a senior strategist at APCO Worldwide.

Robert Michael Kimmitt was United States Deputy Secretary of the Treasury under President George W. Bush. He was nominated by President Bush on June 29, 2005. The United States Senate unanimously confirmed him on July 29, 2005, and he was sworn into office on August 16, 2005. Kimmitt served through the end of the Bush administration, leaving office on January 20, 2009.

Melville Peter McPherson is the president of the Association of Public and Land-grant Universities. He previously served as a special assistant to President Gerald Ford, administrator of USAID under President Ronald Reagan, Deputy Secretary of the U.S. Department of Treasury, President of Michigan State University from 1993 to 2004, and Chairman of Dow Jones.

Mary John Miller is an American government official and political candidate who served as Under Secretary for Domestic Finance and a former Acting Deputy Secretary of the Treasury. In 2020, she announced her candidacy for Mayor of Baltimore but lost to Council President Brandon Scott in the June 2020 Democratic primary.

Justin George Muzinich is an American businessman and former Donald Trump administration official who served as the United States Deputy Secretary of the Treasury, from December 2018 to January 2021. Muzinich previously served as the Counselor to the Secretary at the United States Department of the Treasury. Prior to that, he served as Policy Director for the Presidential Campaign of Jeb Bush.

Sarah Bloom Raskin is an American attorney and regulator, who was formerly a member of the Board of Governors of the Federal Reserve System and a former United States Deputy Secretary of the Treasury. Previously, she served as Maryland Commissioner of Financial Regulation and as a Managing Director at the Promontory Financial Group. She is a Rubenstein Fellow at Duke University.

Neal Steven Wolin is the CEO of the corporate advisory firm Brunswick Group, an equity partner of Data Collective, a board partner of Social Capital, and a limited partner advisor of Nyca Partners. He is the longest-serving Deputy Secretary of the U.S. Department of the Treasury and also served as Acting Secretary of the Treasury in early 2013.