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The American Institute of Mathematics (AIM) is one of eight NSF-funded mathematical institutes. It was founded in 1994 by John Fry, co-founder of Fry's Electronics, and originally located in the Fry's Electronics San Jose, California location. It was privately funded by Fry at inception, and it obtained NSF funding starting in 2002.

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The Institute for Advanced Study (IAS), located in Princeton, New Jersey, in the United States, is an independent center for theoretical research and intellectual inquiry. It has served as the academic home of internationally preeminent scholars, including J. Robert Oppenheimer, Albert Einstein, Hermann Weyl, John von Neumann, and Kurt Gödel, after they immigrated to the United States.

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The Institute for Computational and Experimental Research in Mathematics (ICERM), founded in 2011, is a research institute in mathematics at Brown University, funded beginning in 2010 by a grant from the National Science Foundation. At the time of its founding, the institute was the eighth of its kind in the nation and the first in New England.

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The Institute for Pure and Applied Mathematics (IPAM) is an American mathematics institute funded by the National Science Foundation. The initial funding for the institute was approved in May 1999 and it was inaugurated in August, 2000.

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The Mathematical Biosciences Institute (MBI) is an institution of higher learning affiliated with the Ohio State University in Columbus, Ohio. MBI received major funding from the National Science Foundation.

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The Mathematical Sciences Research Institute (MSRI) is an independent nonprofit mathematical research institution in Berkeley, California. It is widely regarded as a world leading mathematical center for collaborative research, drawing thousands of leading researchers from around the world each year.

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Statistical and Applied Mathematical Sciences Institute (SAMSI) is an applied mathematics and statistics research organization based in Research Triangle Park, North Carolina. It is funded by the National Science Foundation, and is partnered with Duke University, North Carolina State University, the University of North Carolina at Chapel Hill, and the National Institute of Statistical Sciences.