
Charles III was King of Spain (1759–1788). He also was Duke of Parma and Piacenza, as Charles I (1731–1735); King of Naples, as Charles VII, and King of Sicily, as Charles V (1734–1759). He was the fifth son of Philip V of Spain, and the eldest son of Philip's second wife, Elisabeth Farnese. A proponent of enlightened absolutism and regalism, he succeeded to the Spanish throne on 10 August 1759, upon the death of his childless half-brother Ferdinand VI.

Cosimo II de' Medici was Grand Duke of Tuscany from 1609 until his death. He was the elder son of Ferdinando I de' Medici, Grand Duke of Tuscany, and Christina of Lorraine.

Cosimo III de' Medici was the sixth and penultimate Medici Grand Duke of Tuscany. He reigned from 1670 to 1723, and was the elder son of Grand Duke Ferdinando II. Cosimo's 53-year-long reign, the longest in Tuscan history, was marked by a series of laws that regulated prostitution and May celebrations. His reign also witnessed Tuscany's deterioration to previously unknown economic lows. He was succeeded by his elder surviving son, Gian Gastone, when he died, in 1723.

Ferdinando de' Medici was the eldest son of Cosimo III de' Medici, Grand Duke of Tuscany, and Marguerite Louise d'Orléans. Ferdinando was heir to the Grand Duchy of Tuscany, with the title Grand Prince, from his father's accession in 1670 until his death in 1713. He is remembered today primarily as a patron of music. An excellent musician himself, he attracted top musicians to Florence and thus made it an important musical center. Through his patronage of Bartolomeo Cristofori, Ferdinando made possible the invention of the piano.

Ferdinando II de' Medici was grand duke of Tuscany from 1621 to 1670. He was the eldest son of Cosimo II de' Medici and Maria Maddalena of Austria. He was remembered by his contemporaries as a man of culture and science, actively participating in the Accademia del Cimento, the first scientific society in Italy, formed by his younger brother, Leopoldo de' Medici. His 49-year rule was punctuated by the beginning of Tuscany's long economic decline, which was further exacerbated by his successor, Cosimo III de' Medici. He married Vittoria della Rovere, a first cousin, with whom he had two children who reached adulthood: the aforementioned Cosimo III, and Francesco Maria de' Medici, Duke of Rovere and Montefeltro, a cardinal.

Philip de' Medici was the youngest child of Francesco I de' Medici and Joanna of Austria. He was the heir to the Tuscan throne.

Francesco I was the second Grand Duke of Tuscany, ruling from 1574 until his death in 1587, a member of the House of Medici.

Francis I was the Duke of Lorraine and Bar (1729–1737), and later Grand Duke of Tuscany (1737–1765), who married Maria Theresa of Austria and became Holy Roman Emperor (1745–1765) and Archduke of Austria (1740–1765). His wife effectively ruled Austria and the Holy Roman Empire. They were the founders of the Habsburg-Lorraine dynasty. The oldest surviving son of Leopold, Duke of Lorraine, Francis left the duchy for the deposed Polish king Stanisław Leszczyński in exchange for the Grand Duchy of Tuscany as one of the terms ending the War of the Polish Succession in 1738. The duchy and the ducal title to Lorraine and Bar passed to King Louis XV of France upon Leszczynski's death in 1766, though Francis and his successors retained the right to style themselves as dukes of Lorraine and Bar.

Gian Gastone de' Medici was the seventh and last Medicean Grand Duke of Tuscany.