
Comics about the September 11 attacks were published following the terrorist attacks in New York City, Washington DC, and Pennsylvania on September 11, 2001, and cartoonists turned to art to express their grief and support for relief efforts.

Doctor Strange: The Oath is a 2007 comic book limited series written by Brian K. Vaughan, drawn by Marcos Martin, published by Marvel Comics and starring the superhero Doctor Strange. The story follows Doctor Strange as he searches for the person who tried to kill him, while he also looks for a stolen magical elixir that will cure the terminal cancer of Wong, his faithful servant. Doctor Strange finds himself facing another disciple of the Ancient One, who has learned about the elixir and is determined to destroy it.

Ex Machina is an American creator-owned comic book series, created by Brian K. Vaughan and Tony Harris and published by DC Comics under the Wildstorm imprint.

Paper Girls is a mystery/science fiction comic book series written by Brian K. Vaughan and illustrated by Cliff Chiang, published by American company Image Comics. The colorist is Matt Wilson, the letterer and designer is Jared K. Fletcher, and the color flatter is Dee Cunniffe.

Pride of Baghdad is a graphic novel written by Brian K. Vaughan and illustrated by Niko Henrichon released by DC Comics' Vertigo imprint on September 13, 2006. The story is a fictionalized account of the true story of four lions that escaped from the Baghdad Zoo after an American bombing in 2003. The book won the IGN award for best original graphic novel in 2006.

The Private Eye was a science fiction mystery digital comic written by Brian K. Vaughan, drawn by Marcos Martín and colored by Muntsa Vicente. The first issue was published by Panel Syndicate in March 2013. In 2015, the series won an Eisner Award for Best Digital/Webcomic and the Harvey Award for Best Online Comics Work.

Runaways is a superhero comic book series published by Marvel Comics. The series features a group of teenagers who discover that their parents are part of an evil crime organization known as "Pride". Created by Brian K. Vaughan and Adrian Alphona, the series debuted in July 2003 as part of Marvel Comics' "Tsunami" imprint. The series was canceled in September 2004 at issue eighteen, but due to high numbers of trade collection sales, Marvel revived the series in February 2005.

Saga is an epic space opera/fantasy comic book series written by Brian K. Vaughan and illustrated by Fiona Staples, published monthly by the American company Image Comics. The series is heavily influenced by Star Wars and is based on ideas Vaughan conceived both as a child and as a parent. It depicts a husband and wife, Alana and Marko, from long-warring extraterrestrial races, fleeing authorities from both sides of a galactic war as they struggle to care for their daughter, Hazel, who is born in the beginning of the series and who occasionally narrates the series as an unseen adult.

We Stand On Guard is a science fiction comics series written by Brian K. Vaughan, with art by Steve Skroce and colouring by Matt Hollingsworth. The first issue, a large 44 page book, was published by Image Comics in July 2015.

Y: The Last Man is a post-apocalyptic science fiction comic book series by Brian K. Vaughan and Pia Guerra published by Vertigo from 2002 through 2008. The series centers on Yorick Brown and his pet Capuchin monkey Ampersand, the only males who survived the apparent global androcide. The series was published in sixty issues by Vertigo and collected in a series of ten paperback volumes. The series' covers were primarily by J. G. Jones and Massimo Carnevale. The series received three Eisner Awards.