
Channel Zero is a graphic novel by Brian Wood and Becky Cloonan set in a near-future New York City.

Comic Book Tattoo is an eisner award and Harvey Award-winning anthology graphic novel made up of fifty-one stories, each based on or inspired by a song by American singer-songwriter Tori Amos, published by Image Comics in 2008. Rantz Hoseley, longtime friend of Amos, served as the book's editor. Together, Hoseley and Amos gathered eighty different artists to collaborate on the book. Comic Book Tattoo includes an introduction by another longtime friend of Amos, Neil Gaiman, creator of The Sandman series.

Creature Tech is a graphic novel, written and penciled by Doug TenNapel and published by Top Shelf Productions. Elements of the story tie in with TenNapel's previous comic book work Gear.

Flight is an American comics anthology series edited by Kazu Kibuishi, showcasing young and innovative artists and writers. Image Comics published the first two volumes. In June 2005 Kibuishi announced that the series would move from Image to Ballantine Books from Volume Three on in an attempt to increase sales through mainstream bookstores. Kibuishi also stated that subsequent volumes would be released twice-yearly.

Four Letter Worlds is a comics anthology published by American company Image Comics in 2005; it tells 16 stories revolving around four lettered words: Love, Hate, Fear, and Fate.

Hazed is a dark comedy about three young girls’ perilous journey through the world of sororities and eating disorders. It is a 160-page original graphic novel published by Image Comics in 2008, and is created by Mark Sable and Robbi Rodriguez.

Indigo Vertigo is a 48-page graphic novella, written by KatieJane Garside and illustrated by Dogwitch creator, Daniel Schaffer. It was published by Image Comics in 2005.

Iron West is a western steampunk graphic novel by American comic book creator Doug TenNapel. It was published by Image Comics in 2006.

One Model Nation is a graphic novel by Jim Rugg and Dandy Warhols frontman Courtney Taylor-Taylor about a fictional 1970s German krautrock band. It was released on 11 November 2009. An accompanying studio album titled Totalwerks, Vol. 1 (1969–1977), a greatest hits album by the fictional band, was released on 31 January 2012.

Random Acts of Violence is the one shot graphic novel from Image Comics by writer Justin Gray and Jimmy Palmiotti, and artists Giancarlo Caracuzzo and Paul Mounts in 2010.