
John Constantine, Hellblazer: All His Engines is an original graphic novel featuring the DC Comics character John Constantine, written by Mike Carey, with art by Leonardo Manco. The graphic novel is a spin-off of the long-running series Hellblazer, published by the DC Comics imprint Vertigo. It was first published in January 2005. The graphic novel follows John Constantine's investigation into a worldwide phenomenon that is placing innocent people into comas. The graphic novel was adapted into the animated series titled Constantine: City of Demons.

Asterix and the Falling Sky is the thirty-third volume of the Asterix comic book series, the ninth solely written and illustrated by Albert Uderzo and the only volume to introduce science fiction elements into the otherwise historical comedy series. The book was intended as a tribute to Walt Disney and a satire on the state of the French comics industry. It was released on October 14, 2005 to commercial success, but was panned by the critics. This was the final volume produced by Uderzo before handing over the series to a new creative team.

Black Hole is a twelve-issue comic book limited series written and illustrated by Charles Burns and published first by Kitchen Sink Press, then Fantagraphics. It was released in collected form in 2005 by Pantheon Books. The story deals with the aftermath of a sexually transmitted disease that causes grotesque mutations in teenagers. Burns has said that the mutations can be read as a metaphor for adolescence, sexual awakening and the transition into adulthood.

Brodie's Law is a comic book series created by Daley Osiyemi and David Bircham which tells the story of anti-hero, Jack Brodie, East end Gangster, expert thief and professional killer, who in a twist of fate gains the ability to steal his victims' souls and take on their appearance, memories and feelings.

The Clouds Above is a graphic novel by Jordan Crane, recounting the adventures of a boy named Simon and cat named Jack. The pair skip school one day to avoid a nasty teacher and wander onto the roof. The staircase that they discover leads them above the clouds. They meet friendly pink clouds, dangerous storm clouds, and a flock of yellow birds. Their adventure is fast-paced, suitable for readers of many ages.

The Fountain is a graphic novel illustrated by Kent Williams published in 2005 by Vertigo Comics, based on the original script of Darren Aronofsky's film The Fountain.

Good Apollo, I'm Burning Star IV, Volume One: From Fear Through the Eyes of Madness is a graphic novel released in September of 2005 along with the Coheed and Cambria album of the same name. It is written by Claudio Sanchez, illustrated by Christopher Shy, and published by Evil Ink Comics. In 2017, it was rebooted with Sanchez's wife, Chondra added as a writer and Rags Morales as the main artist and Emilio Lopez as the colorist. This version goes into more depth with the story then the previous edition. The project finished in 2019 and an Ultimate Edition was released.

Ice Haven is a 2005 graphic novel by Daniel Clowes. The book's contents were originally published as the comic book Eightball #22 and were subsequently reformatted to make the hardcover Ice Haven book.

Batman: The Man Who Laughs is a one-shot prestige format comic book by Ed Brubaker and Doug Mahnke, released in February 2005, and intended as a successor to Batman: Year One.

Queen Bee is a graphic novel aimed at middle-schoolers about cliques and popularity, written by Chynna Clugston. The book was one of the American Library Association's book picks for 2006.

The Wonderful Wizard of Oz (2005) is a collection of three stories adapting the novel The Wonderful Wizard of Oz (1900) by L. Frank Baum. The stories were written by David Chauvel with art by Enrique Fernandez.