
12 Days is a debut graphic novel/global manga written and illustrated by June Kim. Basing the plot partially on a story told to her by a stranger, Kim began an early version of 12 Days as a sophomore in college to help herself cope with the end of a relationship. After moving on emotionally with her break-up, she stopped developing the comic and later left South Korea to attend the School of Visual Arts in Manhattan, New York, United States, from which she graduated with a Bachelor of Fine Arts in cartooning. Following her successful pitch of 12 Days to manga publisher Tokyopop, she resumed work on it in early 2005 and finished in the middle of August 2006. 12 Days focuses on Jackie Yuen, who decides to drink the ashes of her former lover for twelve days in beverages as a way to cope with her grief over her death.

Fables: 1001 Nights of Snowfall is a graphic novel prequel to the comic book series Fables written by series creator Bill Willingham with a variety of artists. It was released on October 18, 2006 by Vertigo.

American Born Chinese is a graphic novel by Gene Luen Yang. Released in 2006 by First Second Books, it was a finalist for the 2006 National Book Awards in the category of Young People's Literature. It won the 2007 Michael L. Printz Award, the 2007 Eisner Award for Best Graphic Album: New, the Publishers Weekly Comics Week Best Comic of the Year, the San Francisco Chronicle Best Book of the Year, the 2006/2007 Best Book Award from The Chinese American Librarians Association, and Amazon.com Best Graphic Novel/Comic of the Year. It also made the Booklist Top Ten Graphic Novel for Youth, the NPR Holiday Pick, and Time Top Ten Comic of the Year. It was colored by cartoonist Lark Pien, who received the 2007 Harvey Award for Best Colorist for her work on the book.

The Arrival by Shaun Tan is a wordless "graphic novel" published by Hodder Children's Books in 2006. The book is 128 pages long and divided into six chapters; it is composed of small, medium, and large panels, and often features pages of full artwork. It features an immigrant's life in an imaginary world that sometimes vaguely resembles our own. Without the use of dialogue or text, Shaun Tan portrays the experience of a father emigrating to a new land. Tan differentiates The Arrival from children's picture books, explaining that there's more emphasis on continuity in texts with multiple frames and panels, and that a "graphic novel" text like his more closely resembles a film making process. Shaun Tan has said he wanted his book to build a kind of empathy in readers: "In Australia, people don't stop to imagine what it's like for some of these refugees. They just see them as a problem once they're here, without thinking about the bigger picture. I don't expect the book to change anybody's opinion about things, but if it at least makes them pause to think, I'll feel as if I've succeeded in something."

Can't Get No is a 2006 graphic novel by Rick Veitch published by Vertigo.

Marisa Acocella Marchetto is an American cartoonist. She is the author of the New York Times best-selling graphic novel Ann Tenna, the graphic memoir Cancer Vixen, and Just Who the Hell is She, Anyway? She is also a cartoonist for The New Yorker and a columnist for W magazine's website. Her work has appeared in The New York Times, Glamour, and O, The Oprah Magazine.

Cavalcade of Boys is a comic book miniseries by Tim Fish, featuring the lives and loves of several gay characters in America.

Fun Home: A Family Tragicomic is a 2006 graphic memoir by the American cartoonist Alison Bechdel, author of the comic strip Dykes to Watch Out For. It chronicles the author's childhood and youth in rural Pennsylvania, United States, focusing on her complex relationship with her father. The book addresses themes of sexual orientation, gender roles, suicide, emotional abuse, dysfunctional family life, and the role of literature in understanding oneself and one's family.

Hyde & Shriek is a Hardy Boys graphic novel written by Scott Lobdell and illustrated by Sidney Lima and Paulo Henrique. The sixth in the Undercover Brothers graphic novel series, it was published by Papercutz in 2006.

Lost Girls is a graphic novel written by Alan Moore and illustrated by Melinda Gebbie, depicting the sexually explicit adventures of three female fictional characters of the late 19th and early 20th century: Alice from Lewis Carroll's Alice's Adventures in Wonderland and Through the Looking-Glass, Dorothy Gale from L. Frank Baum's The Wonderful Wizard of Oz, and Wendy Darling from J. M. Barrie's Peter and Wendy. They meet as adults in 1913 and describe and share some of their erotic adventures with each other.

Sticky is a book of gay erotic comics written by Dale Lazarov and drawn by Steve MacIsaac.