
Woodrow Huckleberry Tiberius Boyd is a character on the American television show Cheers, portrayed by Woody Harrelson. Woody came to Cheers at the beginning of the fourth season of Cheers in 1985 in the episode "Birth, Death, Love and Rice".

Diane Chambers is a fictional character in the American television situation comedy show Cheers, portrayed by Shelley Long and created by Glen and Les Charles. After her fiancé Sumner Sloan abandons her in the Cheers bar in the pilot episode, Diane works as a bar waitress. She has an on-off relationship with the womanizing bartender Sam Malone and a one-year relationship with Frasier Crane, who later becomes a main character of the series and Frasier. When Long left the series during the fifth season, the producers wrote her character out. After that, they added her permanent replacement Rebecca Howe, a businesswoman played by Kirstie Alley, in the sixth season. Shelley Long made a special guest appearance in the series finale as Diane in the eleventh and final season. Long also appeared in Frasier as Diane's fantasy counterpart in Frasier's dreams and the actual Diane in a crossover episode "The Show Where Diane Comes Back".

Clifford C. Clavin, Jr., is a fictional character on the American television show Cheers played by John Ratzenberger. A postal worker, he is the bar's know-it-all and was a contestant on the game show Jeopardy! Cliff was not originally scripted in the series' pilot episode, "Give Me a Ring Sometime", but the producers decided to add a know-it-all character and Ratzenberger helped flesh it out. The actor made guest appearances as Cliff on The Tortellis, St. Elsewhere, Wings, and Frasier.

Dr. Frasier Winslow Crane is a fictional character on the American television sitcoms Cheers and Frasier, portrayed by Kelsey Grammer. The character debuted in the Cheers third-season premiere, "Rebound " (1984), as Diane Chambers's love interest, part of the Sam and Diane story arc. Intended to appear for only a few episodes, Grammer's performance for the role was praised by producers, prompting them to expand his role and to increase his prominence. Later in Cheers, Frasier marries Lilith Sternin and has a son, Frederick. After Cheers ended, the character moved to a spin-off series Frasier, the span of his overall television appearances totaling twenty years. In the spin-off, Frasier moves back to his birthplace Seattle after his divorce from Lilith, who retained custody of Frederick in Boston, and is reunited with a newly-created family: his estranged father Martin and brother Niles.

Rebecca Howe is a fictional character of the American television sitcom Cheers, portrayed by Kirstie Alley and created by Glen and Les Charles. Rebecca appeared in 147 episodes of Cheers between 1987 and 1993 and in one episode of Wings. She debuts in the season six episode "Home Is the Sailor" after Shelley Long—who played waitress Diane Chambers—left the show to pursue a movie career. Much of the show's humor in previous seasons had been based around the interaction and sexual tension between the womanizing, working-class main character, bartender Sam Malone, and the high-class, snobbish Diane. Rebecca was intended to fill the gap as Sam's new female foil.

Samuel "Mayday" Malone is a fictional character on the American television show Cheers, portrayed by Ted Danson and created by Glen and Les Charles. The central character of the series, Sam, a former relief pitcher for the Boston Red Sox baseball team, is the owner and bartender of the bar called "Cheers". He is also a recovering alcoholic and a notorious womanizer. Although his celebrity status was short-lived, Sam retains that standing within the confines of Cheers, where he is beloved by the regular patrons. Along with Carla Tortelli and Norm Peterson, he is one of only three characters to appear in all episodes of Cheers. Sam has an on-again, off-again relationship with the bar waitress Diane Chambers for the series' first five seasons until her departure from the series. Then he tries to seduce Diane's replacement, Rebecca Howe, who frequently rejects his advances. Sam also appears in "The Show Where Sam Shows Up", a crossover episode of the spin-off Frasier.

Ernie Pantusso, commonly known as "Coach", is a fictional character on the American television show Cheers, portrayed by Nicholas Colasanto between 1982 and 1985. Coach was originally Sam Malone's baseball coach before the show's pilot episode. He later became a bartender of Cheers, while Sam became its owner and another bartender. He is not "worldly wise" but has some shred of wit. He also has a daughter named Lisa, who solely appeared in "Coach's Daughter" (1982), from his late wife Angela.

Hilary Norman "Norm" Peterson is a regular fictional character on the American television show Cheers. The character was portrayed by George Wendt and is named Hilary after his grandfather.

Hilary Norman "Norm" Peterson is a regular fictional character on the American television show Cheers. The character was portrayed by George Wendt and is named Hilary after his grandfather.

Sam Malone and Diane Chambers, collectively known as Sam and Diane, are fictional characters in the American situation comedy television series Cheers. Sam Malone is a working-class, retired baseball player-turned-bartender played by Ted Danson; Diane Chambers is a college-graduate cocktail waitress played by Shelley Long. Danson appeared on Cheers for its entire run of the series; Long was part of the regular cast from the 1982 series premiere until the fifth-season finale, "I Do, Adieu" (1987). Long returned for a special appearance in the 1993 series finale, "One for the Road."

Lilith Sternin is a fictional character on the American television sitcoms Cheers and Frasier, portrayed by Bebe Neuwirth. The character first appears as a date for Frasier Crane, though mutual hostility and discomfort causes the evening to end badly. Several months later, Lilith meets Frasier again and, with some help from Frasier's ex-fiancée, Diane Chambers, they start a romantic relationship, eventually living together, marrying, and having a son, Frederick.

Carla Maria Victoria Angelina Teresa Apollonia Lozupone Tortelli LeBec, commonly known as Carla Tortelli, is a fictional character in the American television show Cheers, portrayed by Rhea Perlman. Outwardly, at least, Carla is a mean-spirited woman who expresses disdain for many people. She had four children with her then-husband Nick when the series started and eight children with three different men when it ended.