
An American Tragedy is a 1925 novel by American writer Theodore Dreiser. He began the manuscript in the summer of 1920, but a year later abandoned most of that text. It was based on the notorious murder of Grace Brown in 1906 and the trial of her lover. In 1923 Dreiser returned to the project, and with the help of his wife Helen and two editor-secretaries, Louise Campbell and Sally Kusell, he completed the massive novel in 1925.

Arrowsmith is a novel by American author Sinclair Lewis, first published in 1925. It won the 1926 Pulitzer Prize. Lewis was greatly assisted in its preparation by science writer Paul de Kruif, who received 25% of the royalties on sales, although Lewis was listed as the sole author. Arrowsmith is an early major novel dealing with the culture of science. It was written in the period after the reforms of medical education flowing from the Flexner Report on Medical Education in the United States and Canada: A Report to the Carnegie Foundation for the Advancement of Teaching, 1910, which had called on medical schools in the United States to adhere to mainstream science in their teaching and research.

Bread Givers is a 1925 three-volume novel by Jewish-American author Anzia Yezierska; the story of a young girl growing up in an immigrant Jewish household in the Lower East Side of New York City. Her parents are from Poland in the Russian Empire.

The Cave Girl is a lost world novel by American writer Edgar Rice Burroughs. Originally published in two separate stories, The Cave Girl begun in February 1913 and published by "All-Story" in July, August, and September 1913; and The Cave Man begun in 1914 and published by "All-Story Weekly" throughout March and April 1917. The book version was first published by A. C. McClurg on 1925-03-21. In August 1949, Dell Paperback published a version with a map captioned "Wild Island Home of Nadara the Cave Girl Where Violence and Bloodshed Rule."

Dark Laughter is a 1925 novel by the American author Sherwood Anderson. It dealt with the new sexual freedom of the 1920s, a theme also explored in his 1923 novel Many Marriages and later works. The influence of James Joyce's Ulysses, which Anderson had read before writing the 1925 novel, is expressed in Dark Laughter.

The Eternal Lover is a fantasy-adventure novel by American writer Edgar Rice Burroughs. The story was begun in November 1913 under the working title Nu of the Niocene. It was first run serially in two parts by All-Story Weekly. The first part, released March 7, 1914 was titled "The Eternal Lover" and the second part, released in four installments from January 23, 1915 to February 13, 1915 was titled "Sweetheart Primeval". The book version was first published by A. C. McClurg on October 3, 1925. In 1963, Ace Paperback published a version under the title The Eternal Savage. An E-Text edition has been published by Edgar Rice Burroughs, Inc. and is available online.

Firecrackers. A Realistic Novel is a 1925 novel by American author Carl Van Vechten. It is one of several fictional works published that same year which assayed the temerity and hedonism of the Jazz Age including F. Scott Fitzgerald's The Great Gatsby and Anita Loos' Gentlemen Prefer Blondes.

Gentlemen Prefer Blondes: The Intimate Diary of a Professional Lady (1925) is a comic novel written by American author Anita Loos. The story primarily follows the escapades and dalliances of a young blonde flapper in New York City and Europe during the Roaring Twenties. It is one of several novels exploring the hedonistic Jazz Age published that year that have become famous—including F. Scott Fitzgerald's The Great Gatsby and Carl Van Vechten's Firecrackers.

The Great Gatsby is a 1925 novel written by American author F. Scott Fitzgerald that follows a cast of characters living in the fictional towns of West Egg and East Egg on prosperous Long Island in the summer of 1922. Many literary critics consider The Great Gatsby to be one of the greatest novels ever written.

The House Without a Key is a novel that was written in 1925 by Earl Derr Biggers. It is the first of the Charlie Chan mysteries written by Biggers.

Invaders from the Dark is a horror novel by American writer Greye La Spina. It was published by Arkham House in 1960 in an edition of 1,559 copies. It was La Spina's first and only hardcover book.

The Lost King of Oz (1925) is the nineteenth in the series of Oz books created by L. Frank Baum and his successors, and the fifth written by Ruth Plumly Thompson. It was Illustrated by John R. Neill.

The Making of Americans: Being a History of a Family's Progress is a modernist novel by Gertrude Stein. The novel traces the genealogy, history, and psychological development of members of the fictional Hersland and Dehning families. Stein also includes frequent metafictional meditations on the process of writing the text that periodically overtake the main narrative.

The Man Nobody Knows (1925) is the second book by the American author and advertising executive Bruce Fairchild Barton. In it, Barton presents Jesus as "[t]he Founder of Modern Business," in an effort to make the Christian story accessible to businessmen of the time.

Manhattan Transfer is an American novel by John Dos Passos published in 1925. It focuses on the development of urban life in New York City from the Gilded Age to the Jazz Age as told through a series of overlapping individual stories.

Porgy is a novel written by the American author DuBose Heyward and published by the George H. Doran Company in 1925.
The Professor's House is a novel by American novelist Willa Cather. Published in 1925, the novel was written over the course of several years. Cather first wrote the centerpiece, “Tom Outland's Story,” and then later wrote the two framing chapters “The Family” and “The Professor.”

Thunder on the Left is a novel by Christopher Morley, originally published in 1925. In it, Morley looks at maturity, individual growth, and human nature. It was adapted as a play by Jean Ferguson Black in 1934.

The Wind (1925), a supernatural novel by Dorothy Scarborough, depicts the loneliness of life in a small Texas town during the 1880s. She originally published it anonymously, anticipating a rough reception in Texas. It was later made into a film called The Wind (1928) starring Lilian Gish.