
Adeline's Dream is the first installment of the realistic fiction novel series From Many Peoples written by Linda Aksomitis. It was first published by Coteau Books in 2006.

Before I Wake (2006) is a novel by Robert J. Wiersema. The events of the novel take place in Victoria, British Columbia, Canada.

Blindsight is a hard science fiction novel by Canadian writer Peter Watts, published by Tor Books in 2006. It won the Seiun Award for best translated novel, and was nominated for the Hugo Award for Best Novel, the John W. Campbell Memorial Award for Best Science Fiction Novel, and the Locus Award for Best Science Fiction Novel. The novel follows a crew of astronauts sent out as the third wave, following two series of probes, to investigate a trans-Neptunian Kuiper belt comet dubbed 'Burns-Caulfield' that has been found to be transmitting an unidentified radio signal to an as-yet unknown destination elsewhere in the solar system, followed by their subsequent first contact. The novel explores questions of identity, consciousness, free will, artificial intelligence, neurology, game theory as well as evolution and biology.

Born to Rock is a 2006 novel by Gordon Korman.

Broken is a fantasy novel by written by Kelley Armstrong. It is the sixth in her Women of the Otherworld series and has the return of Elena Michaels as narrator.

Daaku is a Canadian crime fiction novel by Ranj Dhaliwal.

De Niro's Game is the debut novel by Lebanese-Canadian writer Rawi Hage, originally published in 2006.

The Immaculate Conception is the English translation by Lazer Lederhendler of Gaétan Soucy's French novel, L'Immaculée conception, first published in 1994.

JPod is a novel by Douglas Coupland published by Random House of Canada in 2006. Set in 2005, the book explores the strange and unconventional everyday life of the main character, Ethan Jarlewski, and his team of video game programmers whose last names all begin with the letter 'J'.

The Law of Dreams is a historical fiction novel about the Great Famine of Ireland by Canadian author Peter Behrens. Published in 2006 by House of Anansi Press, it was the recipient of that year's Governor General's Award for English language fiction.

Lullabies for Little Criminals is a 2006 novel by Heather O'Neill.
On the Run is a series of children's novels written by Gordon Korman. It tells a story about two children who try to clear their parents' names, while they are also being hunted by the authorities themselves. The series has six books in total and was published in 2005 through 2006. The series also has a sequel series entitled Kidnapped, which follows the children after this series.

The Other Side of the Bridge is the second novel by Canadian novelist Mary Lawson. It became a bestseller in Canada, and was longlisted for The Booker Prize.

Piece of My Heart is the 16th novel by Canadian detective fiction writer Peter Robinson in the Inspector Banks series. It was published in 2006.

Shattered is a 2006 novel by Eric Walters. It has a foreword from Lieutenant-General Roméo Dallaire, who was the Force Commander for the United Nations Mission to Rwanda.

Sun of Suns, Book One of Virga, is a science fiction novel by Karl Schroeder, published by Tor in 2006. It is set in the fictional world of Virga, a world devoid of gravity containing multiple artificial stars, a fullerene sphere filled with air, drifting rocks and nations floating around Candesce. The story focuses around three main characters: Hayden Griffin, Admiral Chaison Fanning, and his wife Venera Fanning. The sequel to the book, Queen of Candesce, was released in August 2007.

The Thousandfold Thought is the third book in the Prince of Nothing series by Scott Bakker. It was published in January 2006. More specifically the Thousandfold Thought, as envisioned and set into play by Anasûrimbor Moënghus, is the union of the warring faiths of Inrithism and Fanimry under the rule of the Warrior Prophet and Aspect-Emperor of the Three Seas, Anasûrimbor Kellhus, in order to better prepare for the resurrection of the No-God Mog-Pharau by his Consult and the Second Apocalypse he shall bring.

We All Fall Down is a novel by Canadian author Eric Walters, published in 2006 by Random House of Canada. The story follows Will, a ninth-grade student, spending a day with his father at the World Trade Center on September 11, 2001. It was awarded the Red Maple Award in 2007 and was an honor book for the 2008 Manitoba Young Reader's Choice Award.

Widdershins is a 2006 urban fantasy novel by Canadian writer Charles De Lint, set in the Newford universe. It continues the events of the 2001 novel The Onion Girl, where Jilly was left partially paralyzed and her relationship with Geordie unfulfilled. It also deals with a potential war between fairies and "cousins." Fairies, according to the novel, came to the Americas along with the European explorers. Cousins are the original inhabitants, who can take the form of specific animals depending on their bloodline.