
The Adventures of Barry Ween, Boy Genius is a comic book metaseries created, written and illustrated by Judd Winick. It follows the comical escapades of the eponymous character, a 10-year-old boy who secretly possesses the most powerful intellect on Earth, along with his impulsive best friend Jeremy and his crush Sara. Barry puts his genius to work primarily in creating outlandish inventions that are centuries ahead of their time, such as teleportation devices, jetpacks and wallet-sized nuclear devices. Many of the storylines involve one of Barry's inventions going horribly wrong and the two boys' efforts to right the situation before anyone can find out. Barry takes great care to keep his genius a secret and maintains Jeremy as his only confidant. The pair's dialogue is rife with profanity, often complex in its construction, and this foul-mouthed irreverence is reflected to a lesser extent in several of the other characters.

Bad Boy is a one-shot comic book by Frank Miller and Simon Bisley. It was published by American company Oni Press in 1999, as a 44-page prestige format comic book.

Blue Monday is a comic book series created, written and illustrated by Chynna Clugston Flores. The series follows the adventures of Bleu L. Finnegan and her friends as they attend high school during the early 1990s, specifically between the years 1991–93.

The Bunker is a comic book written by Joshua Hale Fialkov with artwork by Joe Infurnari.

Chasing Dogma is a comic book mini-series that chronicles the events of the two fictional stoners Jay and Silent Bob between two of their films: Chasing Amy and Dogma. The series was written by Kevin Smith, creator of View Askew Productions. It was originally published by Oni Press in four issues as Jay & Silent Bob in 1998 and 1999, and later collected in a trade paperback by Image Comics.

Courtney Crumrin is an independent comic book series written and illustrated by Ted Naifeh and released through Oni Press.

The Damned is a horror-noir American comic book created by Cullen Bunn and Brian Hurtt, and published by Oni Press.

Fortune and Glory is a three-issue American comic book limited series by Brian Michael Bendis. It is the story of the author's attempts to break into Hollywood by writing screenplays for his hardboiled comics.

Hopeless Savages is a comic book series created and written by Jen Van Meter, and published by Oni Press. Thus far there have been three 4-issue miniseries, a one-shot, and an original graphic novel, all written by van Meter but each illustrated by a different set of artists, including Christine Norrie, Chynna Clugston, Andi Watson, Bryan Lee O'Malley, Vera Brosgol, and Meredith McClaren.

Invader Zim is an ongoing American comic book series created by Jhonen Vasquez. It is a continuation of the animated television series of the same name that originally aired on Nickelodeon.

Jingle Belle is a fictional comics character created by Paul Dini. The spoiled teenage daughter of Santa Claus, she has a humorously contentious relationship with her famous father. She is usually motivated by feeling unappreciated or being jealous of the attention her father pays to all the children of the world.

Local is a twelve-part Oni Press comic book limited series written by Brian Wood and illustrated by Ryan Kelly.

Madman is a creator owned fictional character, a comic book superhero that appears in comic books by creator Mike Allred and which has been published by a number of publishers over the years. The character first appeared in Creatures of the Id. His name, Frank Einstein, is a combination of Frank Sinatra and Albert Einstein, and is also a reference to Frankenstein.

Mutant, Texas: Tales of Sheriff Ida Red is a four-issue comic book miniseries created and written by Paul Dini and illustrated by J. Bone, published by Oni Press in 2002. The stories take place in a mythical West Texas town changed by a release of atomic power and mystic forces.

Nocturnals is a comic book title created by artist Dan Brereton which debuted as a six-part limited series in 1994–1995 under Malibu Comics collectively subtitled as Black Planet.

PENG! is a one-shot 72 page sports action comic written and drawn by Corey Lewis, published in 2005 by Oni Press.

Polly and the Pirates is an independent comic book series written and illustrated by Ted Naifeh and released through Oni Press.

Scooter Girl is a miniseries by Chynna Clugston, which tells the story of two mod revivalists living in California. It is published by Oni Press and was one of Ain't It Cool News's Vroom Socko's Top Ten Comics of the 2000s.

Scott Pilgrim is a series of graphic novels by Canadian author and artist Bryan Lee O'Malley. The series is about Scott Pilgrim, a slacker and part-time musician who lives in Toronto, Ontario, and plays bass guitar in a band. He falls in love with American delivery girl Ramona Flowers, but must defeat her seven evil exes in order to date her.

The Sixth Gun is a monthly comic book series created by Cullen Bunn and Brian Hurtt and published by Oni Press.

Space Battle Lunchtime is an American comic book created by Natalie Riess and published through Oni Press. The first issue of the eight-issue monthly miniseries was released May 4, 2016. The art received mostly positive reviews, although some critics said the plot was slow or thin.

St. Swithin's Day is a story written by Grant Morrison and drawn by Paul Grist in 1989 for Trident Comics.

Stumptown is an American comic book limited series and later ongoing, written by Greg Rucka with art by Matthew Southworth. The first series launched by Oni Press on November 4, 2009 and ran for four issues. A second miniseries began in September 2012 and ran for five issues and a third volume, this time ongoing, began in September 2014.

Tek Jansen is a fictional character featured on The Colbert Report and in a comic book series published by Oni Press. Jansen originated as a recurring joke in the form of a supposed self-published science fiction novel on the Report, reportedly as a parody of Bill O'Reilly's 1998 novel, Those Who Trespass. The character later appeared on the show in a series of animated shorts entitled Stephen Colbert Presents Stephen Colbert's Alpha Squad 7: A Tek Jansen Adventure, with Jansen voiced by Stephen Colbert, and in 2007 became the protagonist of a five-part comic series.

The Leading Man is a 5-issue limited graphic novel created by B. Clay Moore and Jeremy Haun for Oni Press in 2006 and later compiled in one volume in 2007. Also is known as the first full-color series from the publisher. Universal Pictures is working on a film adaptation with Justin Lin as director.

Three Days in Europe is a five-issue mini-series by Antony Johnston and Mike Hawthorne, published by Oni Press between November 2002 and April 2003.

Wasteland is a monthly comic book series written by Antony Johnston, drawn by Christopher Mitten with covers by Ben Templesmith, and published by Oni Press. It debuted in July 2006 and ended in April 2015.

Whiteout is a comic book limited series by writer Greg Rucka and artist Steve Lieber. It was originally released in four issues during 1998, by Oni Press and then collected into a trade paperback.

Whiteout: Melt is the title of a comic book limited series written by Greg Rucka, illustrated by Steve Lieber, and published by Oni Press in 2000. It is the sequel to Whiteout.