
303 is a six-issue comic-book mini-series created by Garth Ennis and Jacen Burrows, and published by Avatar Press. The story targets a mature audience.

Absolute Boyfriend is a six-volume manga series by Yuu Watase, first serialized in Shōjo Comic. Chuang Yi licensed it for an English language release in Singapore, with the first volume released in March 2005. Viz Media licensed the series for an English release in North America, serializing the series in its Shojo Beat manga anthology as well as releasing the volumes.

X-Men: Age of Apocalypse is a 2005 Marvel Comics six-issue limited series which takes place a year after the last story in the X-Men: Age of Apocalypse one-shot, with Magneto's X-Men helping North America recover from Apocalypse's iron fist. The series was written by Akira Yoshida and pencilled by Chris Bachalo; the first two issues were inked solely by Tim Townsend, with other helping out with the rest.

Angeltown is a 5-issue limited series created in 2005 by writer Gary Phillips and artist Shawn Martinbrough, and published by Vertigo Comics, an imprint of DC Comics. The story is told in the blaxploitation idiom, with nods to the detective stories of Chester Himes and Walter Mosley.

Banzai!, officially stylized BANZAI!, is a discontinued shōnen manga anthology that was published in Germany by Carlsen Verlag, from November 2001 to December 2005. It debuted in November 2001 as a German language adaptation of the popular Japanese manga anthology Weekly Shōnen Jump, published by Shueisha. In addition to various series from Weekly Shōnen Jump, the magazine serialized some original German manga-influenced comics, including Crewman 3. Issues also included educational articles to teach readers Japanese and columns with news updates on anime and manga series. Series published in the magazine were also published in tankōbon volumes under the Banzai! präsentiert and the highly popular series under the Best of Banzai! label. The name Banzai! came from the transliteration of 10,000 years, a traditional Japanese exclamation.

Black Hole is a twelve-issue comic book limited series written and illustrated by Charles Burns and published first by Kitchen Sink Press, then Fantagraphics. It was released in collected form in 2005 by Pantheon Books. The story deals with the aftermath of a sexually transmitted disease that causes grotesque mutations in teenagers. Burns has said that the mutations can be read as a metaphor for adolescence, sexual awakening and the transition into adulthood.
Cattivik was an Italian humoristic comic book character created by Bonvi.

The Complete Crumb Comics is a series of collections from Fantagraphics Books which was intended to reproduce the entire body of American cartoonist and comic book artist/writer Robert Crumb's comics work in chronological order, beginning with his fanzine work from as early as 1958.

Crouching Tiger, Hidden Dragon was a twelve-volume comic series published by Comics One and HK Comics Limited, written by Andy Seto. The comic is based on a 5 book series known as the Crane-Iron Pentalogy.

Elektra: The Hand is a five-issue comic book limited series, written by Akira Yoshida and pencilled by Christian Gossett and published in 2004 by Marvel Comics.

Futari wa Pretty Cure , known as simply Pretty Cure outside Japan, is a Japanese magical girl anime series produced by Toei Animation and broadcast across Japan on TV Asahi's ANN network. It is the first series in the Pretty Cure metaseries created by Izumi Todo. The original series, directed by Daisuke Nishio, aired on TV Asahi between February 1, 2004, and January 30, 2005, in the same timeslot as Izumi Todo's previous work Ashita no Nadja. It was the first of the Pretty Cure series to have received an adapted English-language version, which aired in Canada from March 2009. A direct sequel, Futari wa Pretty Cure Max Heart , or simply Max Heart, aired in Japan between February 6, 2005, and January 29, 2006. It was then succeeded by Futari wa Pretty Cure Splash Star. Two Max Heart movies were released on April 16, 2005, and December 10, 2005, respectively. The series' main motif is yin and yang.

G.I. Joe: A Real American Hero is a comic book that was published by Image Comics from 2001 to 2005. Based on Hasbro, Inc.'s G.I. Joe: A Real American Hero line of military-themed toys, the series picks up seven years after the end of the Marvel Comics series.

Ghostbusters: Legion is a 2004 comic book mini-series published by the Quebec-based publisher, 88MPH Studios run by Canadian Sebastien Clavet. It was written by Andrew Dabb, with pencils by Steve Kurth and inks by Serge LaPointe. The series ran 4 issues from February through May 2004. It was collected as a hardcover collection in 2005 by 88MPH and was supposed to be released via a Diamond Comic Distributors "Previews" exclusive. However, the hardcover never came to pass due to the company's financial problems. It was reprinted as a softcover trade paperback that year, for the UK market by the British Titan Books.

Green Manor is a Franco-Belgian comics series written by Fabien Vehlmann, illustrated by Denis Bodart and published by Dupuis in French and Cinebook in English. I's a humoristic detective series set in the United Kingdom at the end of the 19th century.

Haruhi Suzumiya is a Japanese light novel series written by Nagaru Tanigawa and illustrated by Noizi Ito. It was first published in 2003 by Kadokawa Shoten in Japan with the novel The Melancholy of Haruhi Suzumiya, and has since been followed by 11 additional novel volumes, an anime television series adaptation produced by Kyoto Animation, four manga series, an animated film, two original net animation series and several video games.

Justice League Elite was a twelve-issue comic book limited series published monthly by DC Comics in 2004 and 2005. The title was created by writer Joe Kelly and penciller Doug Mahnke.

Laugh Comics Digest was a publication of Archie Comics that lasted for 200 issues from August 1974 through April 2005. The title was noteworthy because it was not restricted to any character—it often included reprints of stories featuring the popular spinoff character Sabrina, the Teenage Witch, as well as That Wilkin Boy and Super Duck, and sometimes even included reprints from the very obscure title Cosmo the Merry Martian.

Mnemovore is a six-issue comic book limited series published under the Vertigo imprint of DC. The comics were in the horror genre, and ran monthly from June 2005.

Nick Raider is a fictional comic detective whose series was published from 1988 to 2005 by Sergio Bonelli Editore in Italy. Graphically inspired by the American actor Robert Mitchum, it was created by writer Claudio Nizzi and artist Giampiero Casertano. His partner Marvin Brown was inspired by Eddie Murphy. Nick Raider's stories are set in New York City.

Nijigahara Holograph is a Japanese seinen manga series written and illustrated by Inio Asano. It is about the events that occur after a girl is thrown into a well by her classmates and their lives afterwards. The manga was serialized in Ohta Publishing's Quick Japan magazine from 2003 to 2005. It is licensed in North America by Fantagraphics Books.

NYX is a limited series of comic books by Marvel Comics, consisting of seven issues, published between 2003 and 2005. It is written by Joe Quesada with art by Joshua Middleton and Rob Teranishi. NYX stands for District X, New York City.

Ocean is a 2004 six-issue comic book miniseries, written by Warren Ellis with pencils by Chris Sprouse and inks by Karl Story. It was published by American company DC Comics under the Wildstorm imprint.

Promethea is a comic book series created by Alan Moore, J. H. Williams III and Mick Gray, published by America's Best Comics/WildStorm.

Rising Stars is a 24-issue comic book limited series written by J. Michael Straczynski about 113 people born with special abilities following the appearance of a mysterious light in the sky above Pederson, Illinois. The series explores how society may react to the advent of superpowers, and how those who are Specials may react towards society and each other. Rising Stars was one of the first comics produced under Straczynski's own Joe's Comics imprint for Top Cow Productions.

District X, also known as Mutant Town or the Middle East Side, is a fictional location appearing in American comic books published by Marvel Comics. It is a neighborhood in New York City primarily populated by mutants, first seen during Grant Morrison's run on the series New X-Men in New X-Men #127. The ghetto was established in Alphabet City, Manhattan, a neighborhood in the East Village. This would fall within New York's 12th congressional district and the New York City Council's 2nd district. According to the front cover of X-Factor #31, it had a population of 743, having been much reduced by the Decimation.

The Spectacular Spider-Man is a comic book and magazine series starring Spider-Man and published by Marvel Comics.

Spider-Man: India is a comic book originally published in India by Gotham Entertainment Group in 2004, retelling the story of Marvel Comics' Spider-Man in an Indian setting. It ran for four issues, which were later also published in the United States in 2005 and collected into a trade paperback (ISBN 0-7851-1640-0). The series was created by Sharad Devarajan, Suresh Seetharaman, and Jeevan J. Kang with Marvel Comics. The Indian version was conceptualized by Indian director Satyajit Ray, who had once met Stan Lee in New York to discuss creating an Indian version of the superhero. However, this was not done during Ray's lifetime.

Strange Adventures is a series of American comic books published by DC Comics, the first of which was August-September 1950, according to the cover date, and published continuously until November 1973.

Thor: Blood Oath is a 6-issue comic book limited series published by Marvel Comics in September to December 2005 and is written by Michael Avon Oeming, with art by Scott Kolins.

Thor: Son of Asgard is a comic book series published by Marvel Comics from March 2004 to January 2005. Written by Akira Yoshida and illustrated by Greg Tocchini, the series follows Thor's early adventures in Asgard with Sif and Balder. It was originally a limited series of six issues but, thanks to popular demand, it was later extended to an ongoing series that lasted for twelve issues in total.

Too Much Coffee Man (TMCM) is an American satirical superhero created by cartoonist Shannon Wheeler. Too Much Coffee Man wears what appears to be a spandex version of old-fashioned red "long johns" with a large mug attached atop his head. He is an anxious Everyman who broods about the state of the world, from politics to people, exchanging thoughts with friends and readers.

Trudy is the title character of a comic strip about a suburban homemaker by Jerry Marcus which debuted on March 18, 1963. It was syndicated until August 20, 2005, after Marcus died on July 22 of that year.