
Avalon was a webcomic by Josh Phillips set in the fictional city of Avalon, Ontario, Canada. It focused on a group of high school students, and while it was originally gag-a-day, it evolved into a coherent, long-term story with realistic characters. The comic launched on 8 November 1999 and was originally scheduled to end in August 2002. Avalon was a member of Keenspot.

Demonology 101 is a webcomic written and drawn by Faith Erin Hicks from August 1999 to June 2004. It tells the story of Raven, a 16-year-old demon being raised by a human in ordinary human society. Hicks' first public work gained attention as an early story-focused webcomic, and ran for 700 pages before being concluded.

Dicebox, by American cartoonist Jenn Manley Lee, is a science fiction webcomic which has been hosted at the subscription-based comics anthology site Girlamatic. The comic, planned for four books totalling 36 chapters, is set in the space-travelling future and is primarily the story of one year in the lives of two women factory workers, Griffen Medea Stoyka and Molly Robbins.

Diesel Sweeties is a webcomic and former newspaper comic strip written by Richard Stevens III. The comic began in 2000, originally hosted at robotstories.com. From January 2007 until August 2008 it was syndicated to over 20 United States newspapers, including major daily newspapers like The Detroit News and Houston Chronicle.

Digger is a webcomic drawn and written by Ursula Vernon. It is also published in print form by Sofawolf Press.

Dresden Codak is a webcomic written and illustrated by Aaron Diaz. Described by Diaz as a "celebration of science, death and human folly", the comic presents stories that deal with elements of philosophy, science and technology, and/or psychology. The comic was recognized in 2008 at the Web Cartoonist's Choice Awards for Outstanding Use of Color and Outstanding Use of The Medium.

Inverloch is a series of five fantasy graphic novels authored by Sarah Ellerton drawn in a cel-shaded manga style. Inverloch was initially published as a webcomic with new content introduced several pages at a time from 2003 to 2007. Three volumes have seen print with the first three volumes currently available from IndyPlanet and with the first two originally published by Seven Seas Entertainment. Inverloch received several nominations in the 2005, 2006 and 2007 Web Cartoonist's Choice Awards, winning the Outstanding Fantasy Comic category in 2005. During its web publication Inverloch was highly rated at both Topwebcomics and buzzComix online comic rating sites.

Amy Kim Ganter, is an American author and illustrator of original English-language manga.

Shaenon K. Garrity is a webcomic creator and science-fiction author best known for her webcomics Narbonic and Skin Horse. She collaborated with various artists to write webcomics for the Modern Tales-family of webcomic subscription services in the early 2000s, and write columns for various comics journals. Starting in 2003, Garrity begun doing freelance editing work for Viz Media on various manga translations.

Girl Genius is an ongoing comic book series turned webcomic, written and drawn by Phil and Kaja Foglio and published by their company Studio Foglio LLC under the imprint Airship Entertainment. The comic won the Hugo Award for Best Graphic Story three times, has been nominated for a Hugo Award for Best Professional Artist and twice for Eisner Awards, and won multiple WCCA awards.

Goats is a popular webcomic written and illustrated by Jonathan Rosenberg. The webcomic started April 1, 1997. On April 3, 2006, after nine years drawing the strip, Rosenberg became a full-time cartoonist making his living drawing Goats. In 2010, because of work on Scenes from a Multiverse, Goats was put on hiatus. In 2012 Rosenberg raised more than $55.000 via Kickstarter to print Goats Book IV, relaunch the website and finish the story with Goats Book V. In August 19, 2014, 71 comics and all e-books were republished, while Kickstarter backers have yet to receive any merchandise.

Gunnerkrigg Court is a science-fantasy webcomic created by Tom Siddell and launched in April 2005. It is updated online three days a week, and seven volumes of the still continuing comic have been published in print format by Archaia Studios Press and Titan Books. The comic has been critically acclaimed and has won numerous Web Cartoonists' Choice Awards, as well as receiving positive reviews for its artwork and storytelling.

Homestar Runner is an American Adobe Flash adult animated surreal comedy web series created by Mike and Matt Chapman, also known as The Brothers Chaps. It mixes surreal humor, self-parody, and references to 1970s, 1980s, 1990s, and early 2000s pop culture, in particular video games, classic television, and popular music.

Inverloch is a series of five fantasy graphic novels authored by Sarah Ellerton drawn in a cel-shaded manga style. Inverloch was initially published as a webcomic with new content introduced several pages at a time from 2003 to 2007. Three volumes have seen print with the first three volumes currently available from IndyPlanet and with the first two originally published by Seven Seas Entertainment. Inverloch received several nominations in the 2005, 2006 and 2007 Web Cartoonist's Choice Awards, winning the Outstanding Fantasy Comic category in 2005. During its web publication Inverloch was highly rated at both Topwebcomics and buzzComix online comic rating sites.

Jack is a furry webcomic by David Hopkins. It is set in a world populated by anthropomorphic animals.

Kazuhiro "Kazu" Kibuishi is an American graphic novel author and illustrator. He is best known for being the creator and editor of the comic anthology Flight and for creating the webcomic Copper. He is also the author and illustrator of the ongoing Amulet series.

Lackadaisy is a webcomic created by American artist Tracy J. Butler. Set in a Prohibition-era 1927 St. Louis with a population of anthropomorphic cats, the plot chronicles the fortunes of the Lackadaisy speakeasy after its founder is murdered. The comic mixes elements of comedy, crime and mystery. It won multiple Web Cartoonists' Choice Awards in 2007 and 2008, and in April 2011 was nominated for the Eisner Award for "Best Digital Comic".

Mac Hall is a webcomic which was created through a bet between the creator Ian McConville and a friend who claimed he "couldn't make a comic like Penny Arcade". After the fifteenth comic, McConville was joined by Matt Boyd who began to write the comic.

Joey Manley was an American LGBT fiction author, web designer, and webcomics publisher. Manley wrote the successful LGBT novel The Death of Donna-May Dean in 1992. He moved to San Francisco in 2000 in order to work in web design. Manley was the founder and publisher of the Modern Tales family of webcomics websites, which included Modern Tales, Serializer, Girlamatic, Webcomics Nation, and others. Manley is considered one of the "founding pioneers" of the webcomic movement for creating a then-revolutionary subscription model.

Megatokyo (メガトーキョー) is an English-language webcomic created by Fred Gallagher and Rodney Caston. Megatokyo debuted on August 14, 2000, and has been written and illustrated solely by Gallagher since July 17, 2002. Gallagher's style of writing and illustration is heavily influenced by Japanese manga. Megatokyo is freely available on its official website. The stated schedule for updates is Tuesday and Friday, but they typically are posted just once or twice a month on non-specific days. Recently, this schedule has slipped further, due to the health issues of Sarah Gallagher (Seraphim), Fred's wife. Megatokyo was also published in book-format by CMX, although the first three volumes were published by Dark Horse. For February 2005, sales of the comic's third printed volume were ranked third on BookScan's list of graphic novels sold in bookstores, then the best showing for an original English-language manga.

Ryan M. North is a Canadian writer and computer programmer who is the creator and author of Dinosaur Comics, and co-creator of Whispered Apologies and Happy Dog the Happy Dog. He has been the writer of The Unbeatable Squirrel Girl for Marvel Comics since the series debuted in January 2015.

Nowhere Girl is an adult fiction webcomic by Justine Shaw, about a "college student who feels like an outsider in her own life, finding her place in the world and coming to terms with her sexuality". It is named after a song written by British futurist band B-Movie. Since its start in 2001, Nowhere Girl has won several awards. However, the comic has been retired in 2010.

The Order of the Stick (OOTS) is a comedic webcomic that satirizes tabletop role-playing games and medieval fantasy. The comic is written and drawn by Rich Burlew, who illustrates the comic in a stick figure style.

Ozy and Millie is a daily comic strip that ran from 1998 to 2008, created by Dana Simpson and syndicated by North America Syndicate and Andrews McMeel Syndication. It follows the adventures of assorted anthropomorphized animals, centering on Ozy and Millie, two young foxes attending North Harbordale Elementary School in Seattle, contending with everyday elementary school issues such as tests and bullies, as well as more surreal situations.

Penny Arcade is a webcomic focused on video games and video game culture, written by Jerry Holkins and illustrated by Mike Krahulik. The comic debuted in 1998 on the website loonygames.com. Since then, Holkins and Krahulik have established their own site, which is typically updated with a new comic strip each Monday, Wednesday, and Friday. The comics are accompanied by regular updates on the site's blog.

PvP, also known as Player vs Player, is a longrunning video game webcomic, written and drawn by Scott Kurtz. The webcomic follows the events at a fictional video game magazine company, featuring many running gags and references with a focus on nerd culture. Dylan Meconis was added as a co-writer in 2013.

Questionable Content is a slice-of-life webcomic written and drawn by Jeph Jacques. It was launched on August 1, 2003. The plot originally centered on Marten Reed, an indie rock aficionado; his anthropomorphized personal computer Pintsize; his roommate, Faye Whitaker; their mutual friend, Dora Bianchi; and their neighbor Hannelore Ellicott-Chatham. However, over time a supporting cast of characters has grown to include employees of the local coffee shop, neighbors, and androids. QC's storytelling style combines romantic melodrama, situational comedy, and sexual humor, while considering questions of relationships, sexuality, dealing with emotional trauma, and, as of late, artificial intelligence and futurism.

Real Life is an American webcomic drawn and authored by Maelyn Dean that began on November 15, 1999. After having not been updated since December 10, 2015, the comic continued on September 10, 2018. It stopped updating again from July 16, 2019, and recommenced on June 15, 2020. The comic is loosely based around the lives of fictionalized versions of Dean and her friends, including verbatim conversations, as well as fictional aspects including time travel and mecha combat. Characters regularly break the fourth wall. Real Life focuses on humor related to video games and science fiction, and references internet memes.

Saturday Morning Breakfast Cereal (SMBC) is a webcomic by Zach Weinersmith. The gag-a-day comic features few recurring characters or storylines, and has no set format; some strips may be a single panel, while others may go on for ten panels or more. Recurring themes in SMBC include science, research, superheroes, religion, romance, dating, parenting and the meaning of life. SMBC has run since 2002 and is published daily.

Scary Go Round was a 2002 webcomic set in the fictional West Yorkshire town of Tackleford, England, and written by John Allison. Scary Go Round was named one of the best webcomics of 2004 by The Webcomics Examiner. The Sunday Times describes it as "postmodern Brit horror" that is "subtle and stylishly drawn, with a bold cartoon edge". The Morning Star has called it "brilliant, bonkers" and "the best British strip that I've yet found". Scary Go Round won the Web Cartoonist's Choice Awards in 2003 for Outstanding Original Digital Art, in 2005 and in 2007 for Outstanding Comic.

Schlock Mercenary is a comedic webcomic written and drawn by Howard Tayler. It follows the tribulations of a star-travelling mercenary company in a satiric, mildly dystopian 31st-century space opera setting. Since its debut on June 12, 2000, the comic has updated daily, begun to support its author, and been nominated for five Hugo Awards.

VG Cats is a webcomic written and drawn by Canadian cartoonist Scott Ramsoomair. Published on its own website, it featured the adventures of a pair of anthropomorphic cats, who often played the roles of characters in popular video games that are parodied in the strip. Strips were usually presented in a large format and in full color. The author generally set Mondays as days for updating the comic; however, the update schedule had a reputation of being incredibly sporadic; he frequently mocked his tardiness in updating in various strips due to personal reasons, drawing nude drawings on Patreon and frequent convention appearances. As of March 2018, the site had approximately 380 comics listed in its main archives. Based on this archive alone, VG Cats averaged 25 comics a year while it was at its peak. During 2017-2018 that average has gone down to 5 comics a year. The last posted comic was uploaded on March 26, 2018. Scott updated the comic on May 22, 2020, adding a completely different website. Later changes included comic #381, which was planned to be released in February of 2020, and the removal of ads, because Scott said he "doesn't think he's okay with what they are anymore."

Zachary Alexander Weinersmith is an American cartoonist and writer, best known for his webcomic Saturday Morning Breakfast Cereal (SMBC). Outside of SMBC, he is the co-creator of four books, a sketch comedy series, a podcast, and multiple other webcomics.

xkcd, sometimes styled XKCD, is a webcomic created in 2005 by American author Randall Munroe. The comic's tagline describes it as "A webcomic of romance, sarcasm, math, and language". Munroe states on the comic's website that the name of the comic is not an initialism, but "just a word with no phonetic pronunciation".