
Asterix and the Class Act is officially the thirty-second album of the Asterix comic book series, by René Goscinny (stories) and Albert Uderzo, published in 2003. Unlike the other Asterix books, it is a compilation of short stories, rather than one long story. Each story has an introductory page giving some of its original history.

Blankets is an autobiographical graphic novel by Craig Thompson, published in 2003 by Top Shelf Productions. As a coming-of-age autobiography, the book tells the story of Thompson's childhood in an Evangelical Christian family, his first love, and his early adulthood. The book was widely acclaimed, with Time magazine ranking it #1 in its 2003 Best Comics list, and #8 in its Best Comics of the Decade.

Fagin the Jew is a graphic novel by American cartoonist Will Eisner.

Jar of Fools is a once-weekly comic strip by Jason Lutes that was compiled, first into a two-part anthology, and then a graphic novel. The work has received praise from The New York Times Book Review, Spin, Wired, and acclaimed comics creator Chris Ware.

Latter Days is the tenth and final novel in Canadian cartoonist Dave Sim's Cerebus comic book series. It is made up of issues #266-300 of Cerebus. It was collected as the 15th and 16th "phonebook" volumes, as Latter Days and The Last Day.

Louis Riel is a historical biography in comics by Canadian cartoonist Chester Brown, published as a book in 2003 after serializion in 1999–2003. The story deals with Métis rebel leader Louis Riel's antagonistic relationship with the newly established Canadian government. It begins shortly before the 1869 Red River Rebellion, and ends with Riel's 1885 hanging for high treason. The book explores Riel's possible schizophrenia—he believed God had named him Prophet of the New World, destined to lead the Métis people to freedom.

Orbiter is a graphic novel by Warren Ellis and Colleen Doran, published in 2003 by DC Comics under their Vertigo imprint.

Persepolis is an autobiographical series of bande dessinées by Marjane Satrapi that depicts her childhood up to her early adult years in Iran and Austria during and after the Islamic Revolution. The title Persepolis is a reference to the ancient capital of the Persian Empire. Originally published in French, the graphic memoir has been translated to many other languages, including English, Spanish, Catalan, Portuguese, Italian, Greek, Swedish, Finnish, Georgian, Chinese and others. As of 2018, it has sold more than 2 million copies worldwide. Persepolis was written in 2000 and Persepolis 2 was written in 2004.

Switchblade Honey is a 2003 72-page science fiction graphic novel written by Warren Ellis and drawn by Brandon McKinney, published by AiT/Planet Lar.