
Breakfast with Hunter is a 2003 documentary film about the everyday life of gonzo-journalist Hunter S. Thompson by Wayne Ewing.

Buy the Ticket, Take the Ride: Hunter S. Thompson on Film is a 2006 documentary about writer Hunter S. Thompson directed by Tom Thurman.

Uncle Duke is a fictional character in the comic strip Doonesbury by Garry Trudeau. He is nominally Zonker Harris's uncle, albeit an "uncle by courtesy" only. Duke appeared in the strip July 1974 and was originally a straightforward caricature of the gonzo journalist Hunter S. Thompson, but eventually took on a life of his own and a succession of ill-fated ventures in the areas of politics, business and crime.

Fear and Loathing in Las Vegas is a 1998 American film adapted from Hunter S. Thompson's 1971 novel Fear and Loathing in Las Vegas. It was co-written and directed by Terry Gilliam, and stars Johnny Depp and Benicio del Toro as Raoul Duke and Dr. Gonzo, respectively. The film details the duo's journey through Las Vegas as their initial journalistic intentions devolve into an exploration of the city under the influence of psychoactive substances.

For No Good Reason is a 2012 American-British documentary film about Ralph Steadman, directed by Charlie Paul. The film was in competition for the Grierson Award for Best Documentary at the 2012 BFI London Film Festival.

Freak Power: The Ballot or the Bomb is a 2020 American documentary film directed by Ajax Phillips and Daniel Joseph Watkins, based on the book Freak Power: Hunter S. Thompson's Campaign for Sheriff written by Watkins. The film follows journalist Hunter S. Thompson and his 1970 campaign for sheriff of Pitkin County, Colorado, against the incumbent sheriff Carol Whitmire, whose crackdown on marijuana and loitering aimed to incarcerate and intimidate young hippies, or "freaks", into leaving the area. Thompson created and ran under the third party "Freak Power" ticket, with the strategy of registering hundreds of young voters who had never before participated in the democratic process.

Gonzo: The Life and Work of Dr. Hunter S. Thompson is a 2008 documentary film directed by Alex Gibney. It details Hunter S. Thompson's landmark writings on music and politics. Friends and family provide interviews to help describe the mythos of Hunter and his life.

Spider Jerusalem is a fictional character and the protagonist of the comic book Transmetropolitan, created by writer Warren Ellis and artist Darick Robertson, introduced under the now-defunct Helix imprint of DC Comics before being moved to the Vertigo imprint.

Where the Buffalo Roam is a 1980 American semi-biographical comedy film which loosely depicts author Hunter S. Thompson's rise to fame in the 1970s and his relationship with Chicano attorney and activist Oscar "Zeta" Acosta. The film was produced and directed by Art Linson. Bill Murray portrayed the author and Peter Boyle portrayed Acosta, who is referred to in the film as Carl Lazlo, Esq. A number of other names, places, and details of Thompson's life are also changed.