
AnyLogic is a multimethod simulation modeling tool developed by The AnyLogic Company. It supports agent-based, discrete event, and system dynamics simulation methodologies. AnyLogic is a cross-platform simulation software because it works on Windows, macOS and Linux.

Apache Struts 1 is an open-source web application framework for developing Java EE web applications. It uses and extends the Java Servlet API to encourage developers to adopt a model–view–controller (MVC) architecture. It was originally created by Craig McClanahan and donated to the Apache Foundation in May 2000. Formerly located under the Apache Jakarta Project and known as Jakarta Struts, it became a top-level Apache project in 2005.

Audacity is a free and open-source digital audio editor and recording application software, available for Windows, macOS, Linux, and other Unix-like operating systems. Audacity was started in the fall of 1999 by Dominic Mazzoni and Roger Dannenberg at Carnegie Mellon University and was released on May 28, 2000 as version 0.8.

Autodesk Softimage, or simply Softimage is a discontinued 3D computer graphics application, for producing 3D computer graphics, 3D modeling, and computer animation. Now owned by Autodesk and formerly titled Softimage|XSI, the software has been predominantly used in the film, video game, and advertising industries for creating computer generated characters, objects, and environments.

Bacula is an open-source, enterprise-level computer backup system for heterogeneous networks. It is designed to automate backup tasks that had often required intervention from a systems administrator or computer operator.

BearShare was a peer-to-peer file sharing application originally created by Free Peers, Inc. for Microsoft Windows and also a rebranded version of iMesh by MusicLab, LLC, tightly integrated with their music subscription service.

Beonex Communicator is a discontinued open-source Internet suite based on the Mozilla Application Suite (MAS) by Ben Bucksch, a German Mozilla developer. It was intended to have a higher security and privacy level than other commercial products. The Internet suite contains a Web browser, an email and news client, an HTML editor and an IRC client.

C# is a general-purpose, multi-paradigm programming language encompassing static typing, strong typing, lexically scoped, imperative, declarative, functional, generic, object-oriented (class-based), and component-oriented programming disciplines.
CA Anti-Spyware is a spyware detection program distributed by CA, Inc. Until 2007, it was known as PestPatrol.

ChatZilla is an IRC client for Mozilla-based browsers such as Firefox, introduced in 2000. It is cross-platform open source software which has been noted for its consistent appearance across platforms, CSS appearance customization and scripting.

DivX is a brand of video codec products developed by DivX, LLC. There are three DivX codecs: the original MPEG-4 Part 2 DivX codec, the H.264/MPEG-4 AVC DivX Plus HD codec and the High Efficiency Video Coding DivX HEVC Ultra HD codec. The most recent version of the codec itself is version 6.9.2, which is several years old. New version numbers on the packages now reflect updates to the media player, converter, etc.

Drupal is a free and open-source web content management framework written in PHP and distributed under the GNU General Public License. Drupal provides a back-end framework for at least 12% of the top 10,000 websites worldwide – ranging from personal blogs to corporate, political, and government sites. Systems also use Drupal for knowledge management and for business collaboration.

EasyTag is a graphical tag editor for Linux and Microsoft Windows. An attempt to bring EasyTAG to OS X is ongoing. It is written in C and relies on GTK+ and id3lib for graphics and ID3 tag handling respectively. As of version 2.1.1, EasyTag also uses the tag manipulation library provided by the MAD project, for support of ID3v2.4.

eDonkey2000 was a peer-to-peer file sharing application developed by US company MetaMachine, using the Multisource File Transfer Protocol. This client supports both the eDonkey2000 network and the Overnet network.

Ekiga is a VoIP and video conferencing application for GNOME and Microsoft Windows. It is distributed as free software under the terms of the GNU General Public License. It was the default VoIP client in Ubuntu until October 2009, when it was replaced by Empathy. Ekiga supports both the SIP and H.323 protocols and is fully interoperable with any other SIP compliant application and with Microsoft NetMeeting. It supports many high-quality audio and video codecs.

DR-WebSpyder is a DOS web browser, mail client and operating system runtime environment that was developed by Caldera UK in 1997. It was based on the DR-DOS operating system and networking components from Novell as well as the Arachne web browser by Michal Polák of xChaos software. The system was designed to run on low-end desktop systems, but being able to boot and execute from disk as well as from ROM or network, it was also tailored for x86-based thin clients and embedded systems with or without disk drives. Using the web browser as its principal user interface, it could be also used for kiosk systems and set-top boxes. Named Embrowser, it has been ported to Linux in 1999 and was called Embedix Browser since 2000.
FASM is an assembler for x86 processors. It supports Intel-style assembly language on the IA-32 and x86-64 computer architectures. It claims high speed, size optimizations, operating system (OS) portability, and macro abilities. It is a low-level assembler and intentionally uses very few command-line options. It is free and open-source software.

Finnix is a Debian-based Live CD operating system, developed by Ryan Finnie and intended for system administrators for tasks such as filesystem recovery, network monitoring and OS installation. Finnix is a relatively small distribution, with an ISO download size of approximately 100 MiB, and is available for the x86 and PowerPC architectures, and paravirtualized systems. Finnix can be run off a bootable CD, a USB flash drive, a hard drive, or network boot (PXE).

FOAF is a machine-readable ontology describing persons, their activities and their relations to other people and objects. Anyone can use FOAF to describe themselves. FOAF allows groups of people to describe social networks without the need for a centralised database.

Galeon is a discontinued Gecko-based web browser that was created by Marco Pesenti Gritti with the goal of delivering a consistent browsing experience to GNOME desktop environment. It gained some popularity in the early 2000s due to its speed, flexibility in configuration and features.

GameSpy Arcade was a shareware multiplayer game server browsing utility. GameSpy Arcade allowed players to view and connect to available multiplayer games, and chat with other users of the service. It was initially released by GameSpy Industries, in early 2000, to replace the aging GameSpy3D program. Version 2.0.5 was the latest offering of the software, boasting additional features such as increased speed and advanced server sorting abilities.

GCompris is a software suite comprising educational entertainment software for children aged 2 to 10. GCompris was originally written in C and Python using the GTK+ widget toolkit, but a rewrite in C++ and QML using the Qt widget toolkit is since early 2014 in process. GCompris is free and open-source software subject to the requirements of the GNU General Public License version 3 and has been part of the GNU project.

Gephi is an open-source network analysis and visualization software package written in Java on the NetBeans platform.

GoVenture is the brand name for a series of educational computer games and simulations developed and published by MediaSpark Inc. The first GoVenture simulation was launched in 2000 and several more have been launched since. GoVenture educational games and simulations are themed on business and money subjects and are designed to give learners realistic experiences with various business processes and financial topics.

GraphCalc is an open-source computer program that runs in Microsoft Windows and Linux that provides the functionality of a graphing calculator.

Havok is a middleware software suite developed by the Irish company Havok. Havok provides a physics engine component and related functions to video games.

K Desktop Environment 2 was the second series of releases of the K Desktop Environment. There were three major releases in this series.

K-Meleon is an open-source web browser for Microsoft Windows. Originally based on the same Gecko layout engine as Mozilla Firefox and SeaMonkey, K-Meleon's design goal is to provide a fast and reliable web browser while providing a highly customizable interface and using system resources efficiently. Beginning with K-Meleon 76.2G, builds of the browser have utilized the Goanna layout engine instead of the Gecko engine. The browser is released under the GNU General Public License.

The Mac OS X Public Beta was the first publicly available version of Apple Computer's Mac OS X operating system to feature the Aqua user interface. It was released to the public on September 13, 2000 for US$29.95. Its release was significant as the first publicly available evidence of Apple's ability to ship the long-awaited "next-generation Mac operating system" after the Copland failure. It allowed software developers and early adopters to test a preview of the upcoming operating system and develop software for the forthcoming operating system before its final release. It is the only public version of Mac OS X to have a code name not based on a big cat until the release of 10.9 Mavericks in 2013. The US version had a build number of 1H39 and the international version had build number 2E14.

MediaBrowser was a Web browser branding company that started in 2000 by Mark C. Brown. They made specially branded versions of Internet Explorer for various company brands and themes. Because the branded web browsers made by MediaBrowser require Internet Explorer 5 or higher it is only supported on Windows operating systems. On December 5, 2001, Mediabrowser.com, Inc. went bankrupt and shut down their site and its branded web browsers.

Microsoft Office 2001 is a suite of productivity software for Mac OS 8, Mac OS 9, or the Classic environment in Mac OS X. It is the Mac equivalent of Office 2000. It was developed by Microsoft and announced on September 13, 2000 before its release on October 11, 2000.

Miranda IM is an open-source multiprotocol instant messaging application, designed for Microsoft Windows. Miranda is free software distributed under the GNU General Public License.

MPlayer is a free and open-source media player software application. It is available for Linux, OS X and Microsoft Windows. Versions for OS/2, Syllable, AmigaOS, MorphOS and AROS Research Operating System are also available. A port for DOS using DJGPP is also available. Versions for the Wii Homebrew Channel and Amazon Kindle have also been developed.

NetBeans is an integrated development environment (IDE) for Java. NetBeans allows applications to be developed from a set of modular software components called modules. NetBeans runs on Windows, macOS, Linux and Solaris. In addition to Java development, it has extensions for other languages like PHP, C, C++, HTML5, and JavaScript. Applications based on NetBeans, including the NetBeans IDE, can be extended by third party developers.

Netscape 6 is a discontinued Internet suite developed by Netscape Communications Corporation, and was the sixth major release of the Netscape series of browsers. It superseded Netscape Communicator (4.x), as the release of Netscape Communicator 5 was scrapped. Netscape 6 was the first browser of the Netscape line to be based on another source code: Mozilla Application Suite, an open-source software package from the Mozilla Foundation, which was created by Netscape in 1998.

NodeXL is a network analysis and visualization software package for Microsoft Excel 2007/2010/2013/2016. The free version contains network visualization and social network analysis features. The commercial version includes access to social media network data importers, advanced network metrics, and automation. It is a popular package similar to other network visualization tools such as Pajek, UCINet, and Gephi.

Oracle Warehouse Builder (OWB) is an ETL tool produced by Oracle that offers a graphical environment to build, manage and maintain data integration processes in business intelligence systems.

phpBB is an Internet forum package in the PHP scripting language. The name "phpBB" is an abbreviation of PHP Bulletin Board. Available under the GNU General Public License, phpBB is free and open-source.

Pixia is a freeware raster graphics editor program for Windows, created by Isao Maruoka. It was originally designed for the anime/manga community but has also been used in other branches of art.

The Player Project is a project to create free software for research into robotics and sensor systems. Its components include the Player network server and the Stage robot platform simulators. Although accurate statistics are hard to obtain, Player is one of the most popular open-source robot interfaces in research and post-secondary education. Most of the major intelligent robotics journals and conferences regularly publish papers featuring real and simulated robot experiments using Player and Stage.

PunkBuster is a computer program that is designed to detect software used for cheating in online games. It does this by scanning the memory contents of the local machine. A computer identified as using cheats may be banned from connecting to protected servers. The aim of the program is to isolate cheaters and prevent them from disrupting legitimate games. PunkBuster is developed and published by Even Balance, Inc.

Shareaza is a peer-to-peer file sharing client running under Microsoft Windows which supports the gnutella, Gnutella2 (G2), eDonkey, BitTorrent, FTP, HTTP and HTTPS network protocols and handles magnet links, ed2k links, and the now deprecated gnutella and Piolet links. It is available in 30 languages.

SQLite is a relational database management system (RDBMS) contained in a C library. In contrast to many other database management systems, SQLite is not a client–server database engine. Rather, it is embedded into the end program.

Nuendo is a digital audio workstation (DAW) developed by Steinberg for music recording, arranging, editing and post-production. The package is aimed at audio and video post-production market segments, but also contains optional modules that can be used for multiple multimedia creation and audio sequencing.

Surfraw is a free public domain POSIX-compliant command-line shell program for interfacing with a number of web-based search engines. It was created in July 2000 by Julian Assange and is licensed in the public domain and written in the Bourne shell language.

In computing, uClibc is a small C standard library intended for Linux kernel-based operating systems for embedded systems and mobile devices. uClibc was written to support μClinux, a version of Linux not requiring a memory management unit and thus suited for microcontrollers.

Ututo is a Linux distribution consisting entirely of free software. The distribution is named for a variety of gecko found in northern Argentina.

Windows 2000 is a business-oriented operating system that was produced by Microsoft and was released as part of the Windows NT family of operating systems. It was succeeded by Windows XP in 2001, releasing to manufacturing on December 15, 1999 and being officially released to retail on February 17, 2000. It is the successor to Windows NT 4.0.

Windows Millennium Edition, or Windows Me, is a graphical operating system developed by Microsoft as part of its Windows 9x family of operating systems. It is the successor to Windows 98 Second Edition (SE), and was released to manufacturing on June 19, 2000, with general availability on September 14, 2000.

xine is a multimedia playback engine for Unix-like operating systems released under the GNU General Public License. xine is built around a shared library (xine-lib) that supports different frontend player applications. xine uses libraries from other projects such as liba52, libmpeg2, FFmpeg, libmad, FAAD2, and Ogle. xine can also use binary Windows codecs through a wrapper, bundled as the w32codecs, for playback of some media formats that are not handled natively.