
Octavius Valentine Catto was an American educator, intellectual, and civil rights activist in Philadelphia. He became principal of male students at the Institute for Colored Youth, where he had also been educated. Born free in Charleston, South Carolina, in a prominent mixed-race family, he moved north as a boy with his family. He became educated and served as a teacher, becoming active in civil rights. He also became known as a top cricket and baseball player in 19th-century Philadelphia, Pennsylvania.

Sarah Mapps Douglass was an American educator, abolitionist, writer, and public lecturer. Her painted images on her written letters may be the first or earliest surviving examples of signed paintings by an African-American woman. These paintings are contained within the Cassey Dickerson Album. The album is a rare collection of 19th-century friendship letters between a group of women.

Henry Highland Garnet was an African-American abolitionist, minister, educator and orator. Having escaped with his family as a child from slavery in Maryland, he grew up in New York City. He was educated at the African Free School and other institutions, and became an advocate of militant abolitionism. He became a minister and based his drive for abolitionism in religion.

Lemuel Haynes was an American clergyman. A veteran of the American Revolution, Haynes was the first black man in the United States to be ordained as a minister.

Mary Jane Patterson was the first African-American woman to receive a B.A degree, in 1862.

James William Charles Pennington was an African-American orator, minister, writer, and abolitionist active in Brooklyn, New York. He escaped at the age of 19 from slavery in western Maryland and reached New York. After working in Brooklyn and gaining some education, he was admitted to Yale University as its first black student. He completed studies and was ordained as a minister in the Congregational Church, later also serving in Presbyterian churches for congregations in Hartford, Connecticut; and New York. After the Civil War, he served congregations in Natchez, Mississippi; Portland, Maine; and Jacksonville, Florida.

Charles Lewis Reason 1818 – August 16, 1893) was an American mathematician, linguist, and educator. He was the first African-American college professor in the United States, teaching at New York Central College, McGrawville.

John Brown Russwurm (1799–1851) was an abolitionist, newspaper publisher, and colonizer of Liberia where he moved from the United States. He was born in Jamaica to an English father and enslaved mother. As a child he traveled to the United States with his father and received a formal education, becoming the first African American to graduate from Hebron Academy and Bowdoin College.

Alexander Lucius Twilight was an American educator, minister and politician. He is the first African-American man known to have earned a bachelor's degree from an American college or university, graduating from Middlebury College in 1823. He was ordained as a Congregational minister and worked in education and ministry all his career. In 1829 Twilight became principal of the Orleans County Grammar School. There he designed and built Athenian Hall, the first granite public building in the state of Vermont. In 1836 he was the first African American elected as a state legislator, serving in the Vermont House of Representatives; he was also the only African American ever elected to a state legislature before the Civil War.

George Boyer Vashon was an American scholar, poet, and abolitionist.