
Apollo 9 was a March 1969 human spaceflight, the third in NASA's Apollo program. Flown in low Earth orbit, it was the second crewed Apollo mission that the United States launched via a Saturn V rocket, and was the first flight of the full Apollo spacecraft: the command and service module (CSM) with the Lunar Module (LM). The mission was flown to qualify the LM for lunar orbit operations in preparation for the first Moon landing by demonstrating its descent and ascent propulsion systems, showing that its crew could fly it independently, then rendezvous and dock with the CSM again, as would be required for the first crewed lunar landing. Other objectives of the flight included firing the LM descent engine to propel the spacecraft stack as a backup mode, and use of the portable life support system backpack outside the LM cabin.

Apollo 10 was a May 1969 human spaceflight, the fourth crewed mission in the United States Apollo program, and the second to orbit the Moon. It was the F mission: a "dress rehearsal" for the first Moon landing, testing all the components and procedures just short of actually landing. While astronaut John Young remained in the Command Module orbiting the Moon, astronauts Thomas Stafford and Gene Cernan flew the Apollo Lunar Module (LM) to a descent orbit within 8.4 nautical miles (15.6 km) of the lunar surface, the point where powered descent for landing would begin. After orbiting the Moon 31 times Apollo 10 returned safely to Earth, and its success enabled the first actual landing two months later.

The Apollo 11 goodwill messages are statements from leaders of 73 countries around the world on a disc about the size of a 50-cent piece made of silicon that was left on the Moon by the Apollo 11 astronauts.

Apollo 12 was the sixth crewed flight in the United States Apollo program and the second to land on the Moon. It was launched on November 14, 1969, from the Kennedy Space Center, Florida, four months after Apollo 11. Commander Charles "Pete" Conrad and Apollo Lunar Module Pilot Alan L. Bean performed just over one day and seven hours of lunar surface activity while Command Module Pilot Richard F. Gordon remained in lunar orbit. The landing site for the mission was located in the southeastern portion of the Ocean of Storms.

The Apollo insurance covers are autographed postal covers signed by the astronaut crews prior to their mission. The insurance covers began with Apollo 11 and ended with Apollo 16. The ability of astronauts to obtain much life insurance was limited, so they signed hundreds of postal covers before they left, on the presumption that they would become highly valuable in the event of their death. The crew would designate a trusted ally with the covers who would then have them cancelled at the Kennedy Space Center (KSC) post office on the day of launch and/or on the day of the lunar landing.

On 15 April 1969, a United States Navy Lockheed EC-121M Warning Star of Fleet Air Reconnaissance Squadron One (VQ-1) on a reconnaissance mission was shot down by a North Korean MiG-21 aircraft over the Sea of Japan. The plane crashed 90 nautical miles (167 km) off the North Korean coast and all 31 Americans on board were killed, which constitutes the largest single loss of U.S. aircrew during the Cold War era.

The "Environmental Impact of the Big Cypress Swamp Jetport", unofficially known as the "Leopold Report" or the "Leopold-Marshall Report", was a report authored by hydrologist Luna Leopold of the United States Geological Service for the Department of the Interior and officially released on September 17, 1969. Arthur R. Marshall, formerly of the United States Fish and Wildlife Service, helped draft the report. It is considered the first ecological impact report in the state of Florida.

In 1969, the United States FBI, under Director J. Edgar Hoover, continued for a twentieth year to maintain a public list of the people it regarded as the Ten Most Wanted Fugitives.

The Melbourne–Evans collision was a collision between the light aircraft carrier HMAS Melbourne of the Royal Australian Navy (RAN) and the destroyer USS Frank E. Evans of the United States Navy (USN). On 3 June 1969, the two ships were participating in SEATO exercise Sea Spirit in the South China Sea. Around 3:00 am, when ordered to a new escort station, Evans sailed under Melbourne's bow, where she was cut in two. Seventy-four of Evans's crew were killed.

Miss World USA 1969 was the 8th edition of the Miss World USA pageant and it was held in the Baltimore Civic Center in Baltimore, Maryland and was won by Gail Renshaw of Virginia. She was crowned by outgoing titleholder, Johnine Leigh Avery of Washington. Renshaw went on to represent the United States at the Miss World 1969 Pageant in London later that year. She finished as 1st Runner-Up at Miss World. After competing at Miss World, Renshaw resigned her title to get married. Renshaw was replaced by Connie Lee Haggard of Texas who was the 1st Runner-Up of Miss World USA.

The Moratorium to End the War in Vietnam was a massive demonstration and teach-in across the United States against the United States involvement in the Vietnam War. It took place on October 15, 1969, followed a month later, on November 15, 1969, by a large Moratorium March in Washington, D.C.

The United States's Bowline nuclear test series was a group of 47 nuclear tests conducted in 1968–1969. These tests followed the Operation Crosstie series and preceded the Operation Mandrel series.

The United States's Mandrel nuclear test series was a group of 52 nuclear tests conducted in 1969–1970. These tests followed the Operation Bowline series and preceded the Operation Emery series.