
The Spanish missions in Baja California were a large number of religious outposts established by Catholic religious orders, the Jesuits, the Franciscans and the Dominicans, between 1683 and 1834 to spread the Christian doctrine among the Native Americans or Indians living on the Baja California peninsula. The missions gave Spain a valuable toehold in the frontier land, and introduced European livestock, fruits, vegetables, and industry into the region. The Indians were severely impacted by the introduction of European diseases such as smallpox and measles and by 1800 their numbers were a fraction of what they had been before the arrival of the Spanish.

Mission Santa Catarina was founded on November 12, 1797 in the present-day Valle of El Álamo in the municipio of Ensenada, Baja California, México, by the Dominican missionary José Loriente. The ruins of the Mission are located at 31°49′38″N 115°49′16″W.

Mission El Descanso was founded in 1817 among the Kumeyaay by Dominican missionary Tomás de Ahumada at a site 22 kilometers south of the present-day city of Rosarito, Baja California, Mexico.

Misión Santo Domingo was founded among the Kiliwa Indians of Baja California, Mexico, by the Dominicans Miguel Hidalgo and Manuel García in 1775. It is located near Colonia Vicente Guerrero and northeast of San Quintín Bay.

Mission San Miguel was established on 28 March 1787 by the Dominican missionary Luis Sales among the Kumeyaay Indians of northwestern Baja California, Mexico. The ruins of the mission are located in present-day Ejido La Misión, Baja California in the municipio of Ensenada. The mission ruins are behind the local school, on the north side of Highway 1.

Mission Guadalupe was founded by the Dominican missionary Félix Caballero in June 1834, at the site of the modern community of Guadalupe, Baja California. This was the last of the new Dominican missions in Baja California and the only one begun after Mexico had gained its independence in 1821.

Misión El Rosario was the first Dominican mission in Baja California, established in 1774 by Vicente Mora and Francisco Galisteo near the modern town of El Rosario.

Mission San Pedro Mártir was established by the Dominican missionary José Loriente on 27 April 1794, in the Sierra San Pedro mountain range in northern Baja California, Mexico.

Located in Baja California, Mexico about 35 miles southeast of El Rosario, Misión San Fernando Rey de España de Velicatá (1769–1817) was the only mission founded by Franciscans in Baja California.

San Borja was a Spanish mission established in 1762 by the Jesuit Wenceslaus Linck at the Cochimí settlement of Adac, west of Bahía de los Ángeles.

Mission San Vicente was founded in August 1780 by the Dominican missionaries Miguel Hidalgo and Joaquin Valero among the Paipai Indians of northwestern Baja California, Mexico.

Junípero Serra y Ferrer, O.F.M., was a Roman Catholic Spanish priest and friar of the Franciscan Order. He is credited with establishing the Franciscan Missions in the Sierra Gorda, a UNESCO World Heritage Site. He later founded a mission in Baja California and the first nine of 21 Spanish missions in California from San Diego to San Francisco, in what was then Spanish-occupied Alta California in the Province of Las Californias, New Spain.

Mission Santo Tomás de Aquino was founded in what is now Baja California on April 24, 1791 by the Dominican missionary José Loriente, with the authorization of the president of the missions, Juan Crisóstomo Gómez. It was named for Saint Thomas Aquinas.

The visita or subordinate mission station of San Telmo may have been built in the years 1798-1800 by the Dominican missionaries based at Mission Santo Domingo.
