
Fernando de Alencastre Noroña y Silva, 1st Duke of Linares, GE was a Spanish nobleman and military officer. He also served as Viceroy of New Spain, from January 15, 1711 to August 15, 1716.

José Antonio de Alzate y Ramírez was a priest in New Spain, scientist, historian, cartographer, and journalist.
Matías de Armona also Don Matías de Armona was a governor of Las Californias, serving from June 12, 1769 to November 9, 1770, during Spanish Empire colonial rule of New Spain
María Gertrudis Teodora Bocanegra Mendoza was a woman who fought in the Mexican War of Independence. She was arrested, tortured and executed in 1817.

Francisco Javier Clavijero Echegaray, was a Spanish Jesuit teacher, scholar and historian. After the expulsion of the Jesuits from Spanish provinces (1767), he went to Italy, where he wrote a valuable work on the pre-Columbian history and civilizations of Mesoamerica and the central Mexican altiplano.

Atanasio Echeverría y Godoy was an 18th-century Mexican botanical artist and naturalist who trained at the Royal Art Academy in Mexico. The genus Echeveria was named in his honour by Augustin Pyramus de Candolle.

Juan de Esteyneffer was a Moravian German lay Jesuit missionary sent to the New World. He is known for his 1711 work Florilegio Medicinal, which compiled a combination of New World traditional medicine, European materia medica, and 18th-century European medical diagnosis.

Miguel de la Grúa Talamanca de Carini y Branciforte, 1st Marquess of Branciforte was a Sicilian military officer who served as 53rd Viceroy of New Spain from July 12, 1794 to May 31, 1798. He was the only non-Spanish viceroy.

'Pedro Malo de Villavicencio (sometimes Pedro de Malo de Villavicencio) was a member of the Royal Audiencia of Mexico City in the first half of the eighteenth century. From August 1741 to November 3, 1742, he served as viceroy of New Spain, in his capacity as president of the Audiencia.

María Josefa Crescencia Ortíz Téllez–Girón, popularly known as Doña Josefa Ortiz de Domínguez or La Corregidora was an insurgent and supporter of the Mexican War of Independence, which fought for independence against Spain, in the early 19th century. She was married to Miguel Domínguez, corregidor of the city of Querétaro, hence her nickname.
María Rita de la Trinidad Pérez Jiménez, commonly known as Doña Rita Pérez de Moreno, was an insurgent and heroine of the Mexican War of Independence, along with her husband Pedro Moreno.

Gaspar de Portolà i Rovira was a Spanish soldier and administrator in service to the Spanish Empire in the Viceroyalty of New Spain. As commander of the Portolà expedition on land and sea that established San Diego and Monterey, Portolà expanded New Spain's Las Californias province far to the north from its beginnings on the Baja California peninsula. Portolà's expedition also was the first known European to see and record what we now call San Francisco Bay. His expedition gave names to geographic features along the way, many of which are still in use.

María Ignacia Javiera Rafaela Agustina Feliciana Rodríguez de Velasco y Osorio Barba Jimenez Bello De Pereyra Hernandez de Cordoba Salas Solano Garfias, known as la Güera Rodríguez was a Criolla figure in the society of Mexico City, and a proponent of Mexican independence from Spain.

Don Juan Antonio de Urrutia y Arana Perez de Inoriza y Chávarri was a rich and powerful nobleman and patron of the arts in 18th-century Querétaro, in the Viceroyalty of New Spain.

María de la Soledad Leona Camila Vicario Fernández de San Salvador, best known as Leona Vicario, was one of the most prominent figures of the Mexican War of Independence. She was dedicated to informing insurgents of movements in her home Mexico City, the capital of the viceroyalty. She was a member of Los Guadalupes, one of the earliest independence movements in New Spain. She financed the rebellion with her large fortune. She was one of the first female journalists in Mexico. Driven by strong feminist beliefs, she took many risks and sacrificed much wealth in the name of liberation.

The following is a list of Viceroys of New Spain.