
The Anastasian War was fought from 502 to 506 between the Byzantine Empire and the Sasanian Empire. It was the first major conflict between the two powers since 440, and would be the prelude to a long series of destructive conflicts between the two empires over the next century.

The Battle of Hadhramaut took place between the armies of the Sasanian Empire under the command of Spahbed Vahrez and Aksumite forces under King Masruq ibn Abraha in 570. The Aksumite army was defeated by the Sassanids and Masruq was killed.

The Battle of Martyropolis was fought in summer 588 near Martyropolis between an East Roman (Byzantine) and a Sassanid Persian army, and resulted in a Byzantine victory.

The Battle of the Blarathon, also known as the Battle of Ganzak, was fought in 591 near Ganzak between a combined Byzantine–Persian force and a Persian army led by the usurper Bahram Chobin.

The Battle of Gol-Zarriun, also Battle of Bukhara, took place in c. 560 when the Sasanian Empire allied with the First Turkic Khaganate against the Hephthalite Empire.

The Byzantine–Sasanian War of 572–591 was a war fought between the Sasanian Empire of Persia and the Eastern Roman Empire, termed by modern historians as the Byzantine Empire. It was triggered by pro-Byzantine revolts in areas of the Caucasus under Persian hegemony, although other events also contributed to its outbreak. The fighting was largely confined to the southern Caucasus and Mesopotamia, although it also extended into eastern Anatolia, Syria, and northern Iran. It was part of an intense sequence of wars between these two empires which occupied the majority of the 6th and early 7th centuries. It was also the last of the many wars between them to follow a pattern in which fighting was largely confined to frontier provinces and neither side achieved any lasting occupation of enemy territory beyond this border zone. It preceded a much more wide-ranging and dramatic final conflict in the early 7th century.

The Battle of Dara was fought between the Byzantine Empire and the Sasanians in 530. It was one of the battles of the Iberian War.

The Treaty of Dara, also known as the Fifty-Year Peace, was a peace treaty concluded between the Byzantine and Sassanid (Persian) empires at the frontier town of Dara in what is now southern Turkey in 562. The treaty, negotiated by Peter the Patrician for the Byzantine emperor Justinian I and Izadgushasp for the Sassanid king Khosrau I ended the 20-year-long war over the Caucasian kingdom of Lazica. The treaty contained 13 articles, and is well-recorded. It covered all parts of the two empires, Persarmenia, Lazica, the client states, and the Arab allies.

The Fortifications of Derbent are one of the fortified defense lines built by the Persian Sasanian Empire to protect the eastern passage of the Caucasus Mountains against the attacks of the nomadic peoples of the Pontic–Caspian steppe. Built in the 6th century during the reign of Persian emperor Khosrow I and maintained by various later Arab, Turkish and Persian regimes, the fortifications comprise three distinct elements: the citadel of Naryn-Kala at Derbent, the twin long walls connecting it with the Caspian Sea in the east, and the "mountain wall" of Dagh-Bary, running from Derbent to the Caucasus foothills in the west. The immense wall, with a height of up to twenty meters and a thickness of about 10 feet, stretched for forty kilometers between the Caspian Sea and the Caucasus Mountains, thirty north-looking towers stretched for forty kilometers between the Caspian Sea and the Caucasus Mountains, effectively blocking the passage across the Caucasus. The fortification complex was made a UNESCO World Heritage Site in 2003.

The Iberian War was fought from 526 to 532 between the Byzantine Empire and the Sasanian Empire over the eastern Georgian kingdom of Iberia—a Sasanian client state that defected to the Byzantines. Conflict erupted among tensions over tribute and the spice trade.

The Lazic War, also known as the Colchidian War or in Georgian historiography as the Great War of Egrisi, was fought between the East Roman (Byzantine) Empire and the Sasanian Empire for control of the ancient Georgian region of Lazica. The Lazic War lasted for twenty years, from 541 to 562, with varying success and ended in a victory for the Persians, who obtained an annual tribute in exchange for ending the war. The Lazic War is narrated in detail in the works of Procopius of Caesarea and Agathias.

The Sasanian civil war of 589–591 was a conflict that broke out in 589, due to the great deal of dissatisfaction among the nobles towards the rule of Hormizd IV. The civil war lasted until 591, ending with the overthrow of the Mihranid usurper Bahram Chobin and the restoration of the Sasanian family as the rulers of Iran.

The Battle of Satala was fought between the forces of the Eastern Roman (Byzantine) Empire and the Sassanid (Persian) Empire in summer 530, near Satala in Byzantine Armenia. The Persian army approached the city to lay siege, when it was attacked in the rear by a small Byzantine force. The Persians turned back to meet them, but were then attacked by the main army from inside the city. A determined attack by a Byzantine unit led to the loss of the Persian general's flag, causing the panicking Persians to retreat.
The Siege of Dara was raised by the Sasanian king Khosrow I in 573 during the Byzantine–Sasanian War of 572–591. The fortified city fell after 4 months.

The Siege of Phasis took place in 555–556 during the Lazic War between the Byzantine and Sasanian Empires. Expecting an easy victory, the Persians besieged the town of Phasis in Lazica, held by the Byzantines, but were defeated in the ensuing irregular battle. The main source for the siege is the 6th-century historian Agathias.

The Battle of Thannuris (Tannuris) was fought between the forces of the Eastern Roman (Byzantine) Empire under Belisarius and Coutzes and the Persian Sasanian Empire under Xerxes in summer 528, near Dara in northern Mesopotamia. As they were trying to build a fortress in Mindouos, the Byzantines were defeated by the Sasanian army. Belisarius managed to flee but the Sasanians destroyed the buildings. Despite their victory, the Persians suffered heavy losses, angering Kavadh I, the Sasanian king of Persia.