
Pope Alexander VI, was Pope from 11 August 1492 until his death in 1503.

Alfonso de Aragon y Escobar (1417–1495), Duke of Villahermosa, Count of Ribagorza and Cortes and Grand Master of the Order of Calatrava, was an illegitimate son of John II of Aragon and one of his mistresses, Leonor de Escobar, daughter of Alfonso Rodríguez de Escobar.

Juan de Aragón y de Jonqueras, 2nd Count of Ribagorza, was Viceroy of Catalonia (1496–1501) and Viceroy of Naples (1507–1509), replacing Gonzalo Fernández de Córdoba.

Pedro de Arbués was a Spanish Roman Catholic priest and a professed Augustinian canon. He served as an official of the Spanish Inquisition until he was assassinated in the La Seo Cathedral in Zaragoza in 1485 allegedly by Jews and conversos. The veneration of him came swiftly through popular acclaim. His death greatly assisted the Inquisitor-General Tomás de Torquemada's campaign against heretics and crypto-Jews.

Pedro Martínez de Luna y Pérez de Gotor, known as el Papa Luna in Spanish and Pope Luna in English, was an Aragonese nobleman, who as Benedict XIII, is considered an antipope by the Catholic Church.

Francisco Fernández de Bobadilla was an official under the Crown of Castile and a knight of the Order of Calatrava. He was also the brother of doña Beatriz de Bobadilla, marquess of Moya and Peñalosa, a patron of Christopher Columbus and close friend to Queen Isabella. He was sent to the island of Hispaniola as a judge, where he arrested Columbus for supposed irregularities in the latter's government. He served as Viceroy from 1500 until 1502. He died at sea when his convoy was struck by a hurricane.

Bernardo Boyl was an Aragonese monk or friar, known as Fray Buil, who accompanied Christopher Columbus on his second voyage across the Atlantic. On January 6, 1494 Buil conducted the first mass held in the New World, in a temporary church on La Isabela. There is unclear evidence about his affiliation to a religious order. He left the Indies after disagreements with Columbus, and his mission work came to little.

Juan Fernández de Híjar y Cabrera was a Spanish noble of the House of Híjar. He was the son of Juan Fernández de Híjar, the fifth Baron of Hijar and first lord of Lécera. His mother was Juan Fernandez' second wife, Timbor de Cabrera, daughter of Bernardo de Cabrera, first Count of Módica, XXIV Viscount of Cabrera, XXVI Viscount of Bas, and II Viscount of Osuna.

Pope Callixtus III, born Alfonso de Borgia, was head of the Catholic Church and ruler of the Papal States from 8 April 1455 to his death. Borgia spent his early career as a professor of law at the University of Lleida; he later served as a diplomat for the kings of Aragon. He became a tutor for King Alfonso V's illegitimate son Ferdinand. After arranging a reconciliation between Alfonso and Pope Martin V, Borgia was made Bishop of Valencia. In 1444, Pope Eugene IV named him a cardinal, and Borgia became a member of the Roman Curia. During the Siege of Belgrade (1456), Callixtus initiated the custom that bells be rung at midday to remind the faithful to pray for the crusaders. The tradition of the Angelus noon bell still exists in most Catholic Churches to this day. He was also responsible for the retrial of Joan of Arc that saw her vindicated. He appointed two nephews as cardinals, one of whom became Pope Alexander VI.

Antoni Canals (1352-1419) was a Dominican friar, orator and writer. He was born in the Kingdom of Valencia and he was famous for his sermons and by three translations or adaptations of classical works into Catalan.

Gilabert de Centelles y de Cabrera was a Viceroy of Sicily and the son of Gilabert de Centelles y de Riusech, Baron of Nules, and Elionor de Cabrera.

Eleanor, 3rd Countess of Alburquerque became Queen consort of Aragon by her marriage to Ferdinand I of Aragon. In Spanish, she is known as Leonor Urraca de Castilla, condesa de Alburquerque.

Eleanor of Aragon was Queen consort of Cyprus by marriage to Peter I of Cyprus. She was regent of Cyprus during the absence of her spouse in 1366, and regent during the minority of her son Peter II of Cyprus from 1369.

Saint Vincent Ferrer, O.P. was a Valencian Dominican friar and preacher, who gained acclaim as a missionary and a logician. He is honored as a saint of the Catholic Church and other churches of Catholic traditions.

François de Surienne was a Spanish mercenary and engineer, a specialist in fortification and artillery, who was active in Normandy and Burgundy in the 15th century. He was lord of Pisy and of Châtel-Gérard as well as bailli of Chartres and of Saint-Pierre-le-Moûtier. His name is generally given in Spanish as Francisco de Soriano, Sarriera, Sariñera, Siurana, and Sureda. Since he was born in Aragon, he was also known in France by his demonym, the Aragonese.

Ausiàs March was a medieval Valencian poet and knight from Gandia, Valencia. He is considered as one of the most important poets of the "Golden Century" of Catalan literature.

Margaret of Prades was the queen consort of Aragon by marriage to King Martin of Aragon.

Luis Mercader Escolano (1444–1516) was the Grand Inquisitor of the Kingdom of Aragon from 1513 to 1516.
Gabriel Móger or Mòger was a Majorcan painter, sculptor, and poet. He was employed primarily for work on retables and altarpieces by the churches of Majorca. Though Móger's active painting career can be dated to 1426–38 on the basis of surviving documents, his poetic encounter took place some years earlier. A document of 8 March 1404 calls him minor xxv annis et maior tamen xx. By 2 January 1414 he was married and the poem was most likely composed between those dates.
Juan Rejón was an Aragonese captain in the service of the Castilian navy, who was appointed by the Catholic Monarchs to participate in the conquest of the Canary Islands. Rejón founded the city of Las Palmas de Gran Canaria.
Enrique de Villena (1384–1434), also known as Henry de Villeine and Enrique de Aragón, was a Spanish nobleman, writer, theologian and poet. He was also the last legitimate member of the House of Barcelona, the former royal house of Aragon. When political power was denied to him, he turned to writing. He was persecuted by Alfonso V of Aragon and John II of Castile owing to his reputation as a necromancer.

Isabel de Villena was the illegitimate child of Enrique de Villena an unknown noblewoman who rose to become the abbess of the Real Monasterio de la Trinidad of Valencia. As the first major female writer of a work done in the Catalan language, she composed a number of religious treaties. Her most famous work was her Vita Christi. She was also a proto-feminist who tried to change the negative image of women at the time through her writing.

Yolande of Aragon was Duchess of Anjou and Countess of Provence by marriage, who acted regent of Provence during the minority of her son. She was a daughter of John I of Aragon and his wife Yolande of Bar. Yolande played a crucial role in the struggles between France and England, influencing events such as the financing of Joan of Arc's army in 1429 that helped tip the balance in favour of the French. She was also known as Yolanda de Aragón and Violant d'Aragó. Tradition holds that she commissioned the famous Rohan Hours.