
Anna Vasilievna of Moscow was a Byzantine Empress consort by marriage to John VIII Palaiologos. She died while her husband was still the junior co-emperor of the Byzantine Empire.

Demetrios Chalkokondyles, Latinized as Demetrius Chalcocondyles and found variously as Demetricocondyles, Chalcocondylas or Chalcondyles was one of the most eminent Greek scholars in the West. He taught in Italy for over forty years; his colleagues included Marsilius Ficinus, Angelus Politianus, and Theodorus Gaza in the revival of letters in the Western world, and Chalkokondyles was the last of the Greek humanists who taught Greek literature at the great universities of the Italian Renaissance. One of his pupils at Florence was the famous Johann Reuchlin. Chalkokondyles published the first printed publications of Homer, of Isocrates, and of the Suda lexicon.
Laonikos Chalkokondyles, Latinized as Laonicus Chalcocondyles. Incidentally Chalcokondyles is from χαλκος "brass",and κονδυλος "knuckle". He was a Byzantine Greek historian from Athens. He is known for his Histories in ten books, which record the last 150 years of the Byzantine Empire.

Manuel Chrysoloras was a pioneer in the introduction of Greek literature to Western Europe during the Late Middle Ages.

Elia del Medigo, also called Elijah Delmedigo or Elias ben Moise del Medigo and sometimes known to his contemporaries as Helias Hebreus Cretensis or in Hebrew Elijah Mi-Qandia. According to Jacob Joshua Ross, "while the non-Jewish students of Delmedigo may have classified him as an “Averroist”, he clearly saw himself as a follower of Maimonides". But, according to other scholars, Delmedigo was clearly a strong follower of Averroes' doctrines, even the more radical ones: unity of intellect, eternity of the world, autonomy of reason from the boundaries of revealed religion.

Helena Dragaš was the empress consort of Byzantine emperor Manuel II Palaiologos and mother of the last two emperors, John VIII Palaiologos and Constantine XI Palaiologos. She served as regent after the death of her son John VIII in 1448, until the arrival of his successor Constantine XI from Mistra in 1449.

Theodorus Gaza, also called Theodore Gazis or by the epithet Thessalonicensis and Thessalonikeus, was a Greek humanist and translator of Aristotle, one of the Greek scholars who were the leaders of the revival of learning in the 15th century.

Gennadius II was a Byzantine philosopher and theologian, and Ecumenical Patriarch of Constantinople from 1454 to 1464. He was a strong advocate for the use of Aristotelian philosophy in the Eastern Church.

George of Trebizond was a Greek philosopher, scholar and humanist.

Jovan Uroš Nemanjić or John Ouresis Doukas Palaiologos or Joasaph of Meteora, was the ruler of Thessaly from c. 1370 to c. 1373, thereafter retiring as a monk for the nest half century. He died in 1422.

Isidore of Kiev, also known as Isidore of Thessalonica was a Byzantine Greek Metropolitan of Kiev, cardinal, humanist, and theologian. He was one of the chief Eastern defenders of reunion at the time of the Council of Florence.

Helena Kantakouzene was the second wife of David of Trebizond, the last Emperor of Trebizond. Recent research has led to doubts regarding her existence.

Irene Kantakouzene, known simply as Despotess Jerina, was the wife of Serbian Despot Đurađ Branković. In Serbian folk legends, she is the founder of many fortresses in Serbia.

Constantine Lascaris was a Greek scholar and grammarian, one of the promoters of the revival of Greek learning in Italy during the Renaissance, born in Constantinople.
Janus Lascaris, also called John Rhyndacenus, was a noted Greek scholar in the Renaissance.
Saint Laura of Constantinople was a Christian who lived in Constantinople during the 15th century. She was born in Greece into a noble family: her father was a Latin knight named Michael and her mother was Albanian. Her name was Theodolinde Trasci. After she became a nun in Constantinople, she changed it into Laura, eventually rising to become an abbess. She was martyred by the Ottoman Turks who took Constantinople on 29 May 1453. They scalded her to death with the other 52 sisters of her convent. Her feast day is on May 29.
Cleofa Malatesta da Pesaro was an Italian noblewoman and the wife of Theodore II Palaiologos, Despot of the Morea, brother of Constantine XI, the last Byzantine emperor. She was a daughter of Malatesta dei Sonetti, Count of Pesaro, and Isabella Gonzaga. She married Theodore Palaiologos in Mystras on January 21, 1421, or sometime in 1422 in an arranged marriage that was part of an initiative of her uncle, Pope Martin V, to join Western with Orthodox nobility, who in this way hoped to gain political alliances against the Ottoman Turks.

Maria Asanina Palaiologina, better known as Maria of Mangup or Maria of Doros, was the second wife of Prince Stephen the Great and as such Princess consort of Moldavia from September 1472 to 1475 or 1477. Of uncertain parentage, but most likely a descendant of imperial Bulgarian and Byzantine dynasties, she belonged to the ruling class of the small Crimean Principality of Theodoro. Her close relatives included both warring princes of Theodoro, Alexios II and Isaac, as well as Zuan Tzamplakon, diplomat and leader of Stratioti.

Mark of Ephesus was a hesychast theologian of the late Palaiologan period of the Byzantine Empire who became famous for his rejection of the Council of Ferrara-Florence (1438–1439). As a monk in Constantinople, Mark was a prolific hymnographer and a devoted Palamite. As a theologian and a scholar, he was instrumental in the preparations for the Council of Ferrara-Florence, and as Metropolitan of Ephesus and delegate for the Patriarch of Alexandria, he was one of the most important voices at the synod. After renouncing the Council as a lost cause, Mark became the leader of the Orthodox opposition to the Union of Florence, thus sealing his reputation as a defender of Eastern Orthodoxy and pillar of the Eastern Orthodox Church.

Michael Tarchaniota Marullus or Michael Marullus was a Greek Renaissance scholar, poet of Neo-Latin, humanist and soldier.

Marcus Musurus was a Greek scholar and philosopher born in Candia, Venetian Crete.

Helena Palaiologina was a Byzantine princess of the Palaiologos family, who became the Queen consort of Cyprus and Armenia, titular Queen consort of Jerusalem, and Princess of Antioch through her marriage to King John II of Cyprus and Armenia. She was the mother of Queen Charlotte of Cyprus.
Zoe Palaiologina, who later changed her name to Sophia Palaiologina, was a Byzantine princess, member of the Imperial Palaiologos family, Grand Princess of Moscow as the second wife of Grand Prince Ivan III. Through her eldest son Vasili III, she was also the grandmother of Ivan the Terrible, the first Tsar of All Russia.

Andreas Palaiologos or Palaeologus, sometimes anglicized to Andrew, was the eldest son of Thomas Palaiologos, Despot of the Morea. Thomas was a brother of Constantine XI Palaiologos, the final Byzantine emperor. After his father's death in 1465, Andreas was recognized as the titular Despot of the Morea and from 1483 onwards, he also claimed the title "Emperor of Constantinople".

Demetrios Palaiologos or Demetrius Palaeologus was Despot of the Morea together with his brother Thomas from 1449 until the fall of the despotate in 1460. Demetrios and Thomas were sons of Byzantine Emperor Manuel II Palaiologos, and brothers of the final two emperors John VIII and Constantine XI. Demetrios had a complicated relationship with his brothers, who he frequently quarreled with, usually over the matter of Demetrios's wish to establish himself as the most senior of them and claim the imperial throne for himself.

Angelos Pitzamanos (1467–1535) was a Greek Renaissance painter.

Georgius Gemistus, later called Plethon, was one of the most renowned philosophers of the late Byzantine era. He was a chief pioneer of the revival of Greek scholarship in Western Europe. As revealed in his last literary work, the Nomoi or Book of Laws, which he only circulated among close friends, he rejected Christianity in favour of a return to the worship of the classical Hellenic Gods, mixed with ancient wisdom based on Zoroaster and the Magi.

Theodore II Palaiologos or Palaeologus was Despot in the Morea from 1407 to 1443 and in Selymbria from then until his death.

Jovan Uroš Nemanjić or John Ouresis Doukas Palaiologos or Joasaph of Meteora, was the ruler of Thessaly from c. 1370 to c. 1373, thereafter retiring as a monk for the nest half century. He died in 1422.