
Edward Spencer Abraham is an American attorney, author and politician who was a United States Senator from Michigan from 1995 to 2001 and the tenth United States Secretary of Energy, serving under President George W. Bush, from 2001 to 2005. Abraham, a Republican, is one of the founders of the Federalist Society and a co-founder of the Harvard Journal of Law and Public Policy. To date, Abraham is the last Republican to serve as a U.S. Senator from Michigan.

John David Ashcroft is an American lawyer, lobbyist, songwriter and former politician who served as the 79th U.S. Attorney General (2001–2005), in the George W. Bush Administration. He later founded The Ashcroft Group, a Washington D.C. lobbying firm.

Samuel Wright Bodman III was an American businessman, engineer, and politician who served as the 11th United States Secretary of Energy during the George W. Bush administration, from 2005 to 2009. He was also, at different times, the Deputy Secretary of the Treasury and the Deputy Secretary of Commerce.

Joshua Brewster Bolten is an American lawyer and politician. Bolten served as the White House Chief of Staff to U.S. President George W. Bush, replacing Andrew Card on April 14, 2006. Since 2017, he has been president and CEO of the Business Roundtable.

Andrew Hill Card Jr. is an American politician who was White House Chief of Staff under President George W. Bush from 2001 to 2006, as well as head of Bush's White House Iraq Group. Card served as United States Secretary of Transportation under President George H. W. Bush from 1992 to 1993.

Elaine Lan Chao is an American executive and public servant who serves as the United States Secretary of Transportation, having assumed office on January 31, 2017. A member of the Republican Party, Chao was previously Secretary of Labor under President George W. Bush from 2001 to 2009.

Michael Chertoff is an American attorney who was the second United States Secretary of Homeland Security, serving under President George W. Bush. He was the co-author of the USA PATRIOT Act. He previously served as a United States Circuit Judge of the United States Court of Appeals for the Third Circuit, as a federal prosecutor, and as Assistant U.S. Attorney General. He succeeded Tom Ridge as U.S. Secretary of Homeland Security on February 15, 2005.

Kenneth W. Dam served as Deputy Secretary of the Treasury from 2001 to 2004, where he specialized in international economic development. He is currently a senior fellow of the Brookings Institution and a professor emeritus and senior lecturer at the University of Chicago Law School.

Mitchell Elias Daniels Jr. is an American academic administrator, businessman, author, and retired politician who served as the 49th Governor of Indiana, from 2005 to 2013, as a Republican. Since 2013, Daniels has been president of Purdue University.

Donald Louis Evans is an American businessman. He was the 34th U.S. Secretary of Commerce. He was appointed by his longtime friend George W. Bush and sworn into office on January 20, 2001. On November 9, 2004, the White House announced that Evans intended to resign by the end of January 2005.

Robert Michael Gates is an American intelligence analyst, and university president who served as the 22nd United States Secretary of Defense from 2006 to 2011. He was originally appointed by President George W. Bush and was retained for service by President Barack Obama. Gates began his career serving as an officer in the United States Air Force but was quickly recruited by the Central Intelligence Agency (CIA). Gates served for 26 years in the CIA and the National Security Council, and was Director of Central Intelligence under President George H. W. Bush. After leaving the CIA, Gates became president of Texas A&M University and was a member of several corporate boards. Gates served as a member of the Iraq Study Group, the bipartisan commission co-chaired by James A. Baker III and Lee H. Hamilton, that studied the lessons of the Iraq War.

Alberto R. Gonzales is an American lawyer who served as the 80th United States Attorney General, appointed in February 2005 by President George W. Bush, becoming the highest-ranking Hispanic American in executive government to date. He was the first Hispanic to serve as White House Counsel. Earlier he had been Bush's General Counsel during his governorship of Texas. Gonzales had also served as Secretary of State of Texas and then as a Texas Supreme Court Justice.

Carlos Miguel Gutierrez is an American former CEO and former United States Secretary of Commerce. He is currently a Co-Founder and Executive Chairman of EmPath, a Skills Intelligence Software as a Service machine learning company that uses proprietary software to enable large and complex organizations to discover and grow employee's skills by identifying their proficiencies and deficiencies and enabling their efficient redeployment, up-skilling, re-skilling, and training.

Eric Himpton Holder Jr. is an American lawyer who served as the 82nd Attorney General of the United States from 2009 to 2015. Holder, serving in the administration of President Barack Obama, was the first African American to hold the position of U.S. Attorney General.

Alphonso R. Jackson served as the 13th United States Secretary of Housing and Urban Development (HUD). He was nominated by President George W. Bush on January 28, 2004 and confirmed by the Senate on March 31, 2004. Jackson announced his resignation on March 31, 2008.

Michael Owen Johanns is an American attorney and politician who served as a United States Senator from Nebraska from 2009 to 2015. He served as the 38th governor of Nebraska from 1999 until 2005, and was chair of the Midwestern Governors Association in 2002. In 2005, he was appointed by President George W. Bush to serve as the Secretary of Agriculture, where he served from 2005 to 2007, becoming the fourth Nebraskan to hold that position.

Stephen Lee Johnson is an American politician who served as the Administrator of the Environmental Protection Agency (EPA) under President George W. Bush during the second term of his administration. He has received the Presidential Rank Award, the highest award that can be given to a civilian federal employee.

Dirk Arthur Kempthorne is an American politician who was the United States Secretary of the Interior from 2006 to 2009, serving under President George W. Bush. A Republican, Kempthorne previously served as a United States Senator from Idaho from 1993 to 1999 and as the 30th Governor of Idaho from 1999 to 2006. He is known for his conservative views, particularly on economic issues.

Robert M. Kimmitt was United States Deputy Secretary of the Treasury under President George W. Bush. He was nominated by President Bush on June 29, 2005. The United States Senate unanimously confirmed him on July 29, 2005, and he was sworn into office on August 16, 2005. Kimmitt served through the end of the Bush administration, leaving office on January 20, 2009.

Michael Okerlund Leavitt is an American politician who served as the 14th Governor of Utah from 1993 to 2003 in the Republican Party, as Administrator of the Environmental Protection Agency from 2003 to 2005 and as Secretary of Health and Human Services from 2005 to 2009.

James Milton Loy is a retired United States Coast Guard admiral who served as Acting United States Secretary of Homeland Security in 2005 and U.S. Deputy Secretary of Homeland Security (DHS) from December 4, 2003, to March 1, 2005. Prior to his appointment as the DHS Deputy Secretary, he served as the second administrator of the Transportation Security Administration from 2002 to 2003, and before that as the Commandant of the U.S. Coast Guard from 1998 to 2002.

Gordon Hall Mansfield was an American military veteran who was Deputy Secretary of Veterans Affairs between 2004 and 2008.

Melquíades Rafael Ruiz Martínez, is a Cuban-American lobbyist and former politician who served as a United States Senator from Florida from 2005 to 2009 and as general chairman of the Republican Party from November 2006 until October 19, 2007. Previously, Martínez served as the 12th Secretary of Housing and Urban Development under President George W. Bush. Martínez is a Cuban-American and Roman Catholic. He announced he was resigning as general chairman of the Republican National Committee on October 19, 2007.

Norman Yoshio Mineta is an American politician. A member of the Democratic Party, Mineta most recently served in President George W. Bush's Cabinet as the United States Secretary of Transportation, the only Democratic Cabinet Secretary in the Bush administration. On June 23, 2006, Mineta announced his resignation after more than five years as Secretary of Transportation, effective July 7, 2006, making him the longest-serving Transportation Secretary in the Department's history. On July 10, 2006, Hill & Knowlton, a public relations firm, announced that Mineta would join it as a partner. On August 10, 2010, it was announced that Mineta would join L&L Energy, Inc as Vice Chairman.

Michael Bernard Mukasey is an American attorney and former federal judge who served as the 81st Attorney General of the United States from 2007 to 2009.

Robert James Nicholson is an attorney, real estate developer, and a former Republican Party chairman. He was the United States Secretary of Veterans Affairs from January 26, 2005, until October 1, 2007.

Gale Ann Norton served as the 48th United States Secretary of the Interior from 2001 to 2006 under President George W. Bush. She was the first woman to hold the position. Previously, Norton had served as Colorado's Attorney General.

James Allen Nussle is an American businessman and retired politician who has been president and chief executive officer of the Credit Union National Association since 2014. A member of the Republican Party, Nussle served as a member of the United States House of Representatives from 1991 to 2007, was the Republican nominee for the 2006 Iowa gubernatorial election, losing to Democrat Chet Culver, before his appointment as Director of the Office of Management and Budget (OMB) in 2007 by President George W. Bush, an office he retained until 2009.

Paul Henry O'Neill served as the 72nd United States Secretary of the Treasury for part of President George W. Bush's first term, from January 2001 to December 2002. He was fired in December 2002 for his public disagreement with the administration. Prior to his term as Secretary of the Treasury, O'Neill was chairman and CEO of industrial giant Alcoa and chairman of the RAND Corporation.

Roderick Raynor Paige served as the 7th United States Secretary of Education from 2001 to 2005. Paige, who grew up in Mississippi, moved from classroom teacher to college dean and school superintendent to be the first African American to serve as the U.S. education chief.

Henry Merritt "Hank" Paulson Jr. is an American banker who served as the 74th United States Secretary of the Treasury from 2006 to 2009. Prior to his role in the Department of the Treasury, Paulson was the chairman and chief executive officer (CEO) of Goldman Sachs.

James Benjamin Peake was the sixth United States Secretary of Veterans Affairs, serving from 2007 to 2009. In 2004, he retired from a 38-year United States Army career. He also served as the 40th Surgeon General of the United States Army.

Mary E. Peters served as the United States Secretary of Transportation under President George W. Bush from 2006 to 2009. She was the second woman to hold the position after Elizabeth Dole.

Robert Jones Portman is an American politician, currently serving as the junior United States Senator from Ohio. A Republican, Portman previously served as a U.S. Representative, the 14th United States Trade Representative, and the 35th Director of the Office of Management and Budget (OMB).

Colin Luther Powell is an American politician, diplomat and retired four-star general who served as the 65th United States Secretary of State from 2001 to 2005. A member of the Republican Party, Powell was the first African-American Secretary of State. Powell served as the 16th United States National Security Advisor from 1987 to 1989 and as the 12th Chairman of the Joint Chiefs of Staff from 1989 to 1993.

Steven C. Preston is currently president and CEO of Goodwill Industries International, the organization that works to help individuals achieve greater independence through employment, with programs for youth, seniors, and veterans, as well as people with disabilities, criminal backgrounds, and other specialized needs. He formerly served as the 14th Secretary of the U.S. Department of Housing and Urban Development from 2008 to 2009 and the 22nd Administrator of the U.S. Small Business Administration from 2006 until his appointment as HUD Secretary. Before entering public service, Preston spent nearly 25 years in financial and operational leadership positions in the private sector.

Anthony Joseph Principi is the former United States Secretary of Veterans Affairs. He was appointed by President George W. Bush on January 23, 2001, and resigned on January 26, 2005. He Chaired the 2005 Defense Base Closure and Realignment Commission, BRAC and is currently serving as a Consultant & Board member of several diverse Foundations & Corporations.

Condoleezza "Condi" Rice is an American diplomat, political scientist, civil servant, and professor who served as the 66th United States Secretary of State from 2005 to 2009 and as the 20th United States National Security Advisor from 2001 to 2005. A member of the Republican Party, Rice was the first female African-American Secretary of State and the first woman to serve as National Security Advisor.

Thomas Joseph Ridge is an American politician and author who served as the Assistant to the President for Homeland Security from 2001 to 2003, and the first United States Secretary of Homeland Security from 2003 to 2005. Prior to this, Ridge was a member of the United States House of Representatives from 1983 to 1995 and the 43rd Governor of Pennsylvania from 1995 to 2001. He is a member of the Republican Party.

Donald Henry Rumsfeld is an American former politician. Rumsfeld served as Secretary of Defense from 1975 to 1977 under Gerald Ford, and again from January 2001 to December 2006 under George W. Bush. He is both the youngest and the second-oldest person to have served as Secretary of Defense. Additionally, Rumsfeld was a three-term U.S. Congressman from Illinois (1963–69), director of the Office of Economic Opportunity (1969–70), counsellor to the president (1969–73), the United States Permanent Representative to NATO (1973–74), and White House Chief of Staff (1974–75). Between his terms as Secretary of Defense, he served as the CEO and chairman of several companies.

Edward Thomas Schafer is an American businessman and politician who was the 30th governor of North Dakota from 1992 to 2000. Schafer also served as the 29th United States Secretary of Agriculture from 2008 to 2009, appointed by President George W. Bush. From January to July 2016 he served as interim president of the University of North Dakota.

Susan Carol Schwab is an American politician, who served under President George W. Bush as United States Trade Representative from June, 2006 to January, 2009.

John William Snow is the former CEO of CSX Corporation, and served as the 73rd United States Secretary of the Treasury under U.S. President George W. Bush. He replaced Secretary Paul O'Neill on February 3, 2003 and was succeeded by Henry Paulson on July 3, 2006, in a move that had been anticipated. Snow submitted a letter of resignation on May 30, 2006, effective "after an orderly transition period for my successor." Snow announced on June 29, 2006 that he had completed his last day on the job; Robert Kimmitt served as acting secretary until Paulson was sworn in.

Margaret M. LaMontagne Spellings is an education administrator and American politician. Spellings was the President of the University of North Carolina, overseeing the seventeen campus system from March 1, 2016 until March 1, 2019 and is currently the CEO and President of Texas 2036.

Tommy George Thompson is an American Republican politician and the current President of the University of Wisconsin System, serving on an interim basis since July 1, 2020. He previously served as the 42nd Governor of Wisconsin and was the 19th United States Secretary of Health and Human Services, in the cabinet of U.S. President George W. Bush.

Ann Margaret Veneman is the former executive director of UNICEF, serving from 2005 to 2010. Her appointment was announced on January 18, 2005 by UN Secretary-General Kofi Annan. Previously, Veneman was the United States Secretary of Agriculture, the first, and to date the only, woman to hold that position. Veneman served as USDA Secretary from January 20, 2001 to January 20, 2005, leaving to become the fifth executive director of UNICEF. She served in this position from May 1, 2005. A lawyer, Veneman has practiced law in Washington, DC and California, including being a deputy public defender. She has also served in other high level positions in U.S. federal and state government, including being appointed California's Secretary of Food and Agriculture, serving from 1995 to 1999.

John P. Walters is a former Director of the White House Office of National Drug Control Policy (ONDCP) in the George W. Bush administration. He held that position from December 7, 2001 to January 20, 2009. As the U.S. "Drug Czar", Walters coordinated all aspects of federal anti-drug policies and spending. As drug czar, he was a staunch opponent of drug decriminalization, legalization, and medical marijuana.

Christine Todd Whitman is an American Republican politician and author who served as the 50th Governor of New Jersey, from 1994 to 2001, and as Administrator of the Environmental Protection Agency in the administration of President George W. Bush from 2001 to 2003. She is the first woman elected governor of New Jersey.

Robert Bruce Zoellick is an American public official and lawyer who was the eleventh president of the World Bank, a position he held from July 1, 2007 to June 30, 2012. He was previously a managing director of Goldman Sachs, United States Deputy Secretary of State and U.S. Trade Representative, from February 7, 2001 until February 22, 2005. Zoellick has been a senior fellow at Harvard's Belfer Center for Science and International Affairs since ending his term with the World Bank. He is currently a Senior Counselor at Brunswick Group.