
The 2014 South American Games was a multi-sport event that took place in Santiago, Chile. It was the 10th edition of the ODESUR South American Games. Santiago hosted this event for the second time, the first being in 1986. Most of the events took place in and around the National Stadium. The games were held between March 7 to 18.

The 2019 United Nations Climate Change Conference, also known as COP25, is the 25th United Nations Climate Change conference. It was held in Madrid, Spain, from 2 to 13 December 2019 under the presidency of the Chilean government. The conference incorporated the 25th Conference of the Parties to the United Nations Framework Convention on Climate Change (UNFCCC), the 15th meeting of the parties to the Kyoto Protocol (CMP15), and the second meeting of the parties to the Paris Agreement (CMA2).

Civil protests have taken place throughout Chile in response to a raise in the Santiago Metro's subway fare, the increased cost of living, privatisation and inequality prevalent in the country. Due to the magnitude and diversity of these manifestations, they are referred to by Chilean media as an estallido social.

The 2015 Copa América was the 44th edition of the Copa América, the main international football tournament for national teams in South America, and took place in Chile between 11 June and 4 July 2015. The competition was organized by CONMEBOL, South America's football governing body.
The 2015 Copa América Final was the final match of the 2015 Copa América, an international football tournament organized by CONMEBOL that was played in Chile.

The 2019–2020 Chilean protests are characterised by widespread eye injuries including many globe ruptures among protesters as result of Chilean riot police's use of "rubber" bullets and tear gas grenades. Data from the National Institute of Human Rights (INDH) shows that the use of "rubber" bullets and pellets by security forces has left at least 1863 injured, including 268 with eye problems. According to the Chilean Ophthalmology Society, this is the highest number of injuries of this type registered during protests or in conflict zones in the world. In late November, security forces announced the suspension of the use of "rubber" pellets as a crowd control method in the protests. The INDH updated figures at the end of January 2020 reporting that 427 persons had received eye injuries at the hands of the police. Almost 90% of the injured are men. As of early January 2020 the age of injured goes from 14 to 59 years, and averages 28 years.

On 8 September 2014, a fire extinguisher bomb exploded in the Escuela Militar metro station in Santiago, Chile, injuring 14 people, several seriously. Though no group or individual has claimed responsibility, the attacks have been attributed to the Chilean Anarchist group, Conspiracy of Cells of Fire.