
The Battle of the Aegates was a naval battle fought on 10 March 241 BC between the fleets of Carthage and Rome during the First Punic War. It took place among the Aegates Islands, off the western coast of the island of Sicily. The Carthaginians were commanded by Hanno, and the Romans were under the overall authority of Gaius Lutatius Catulus, but Quintus Valerius Falto commanded during the battle. It was the final and deciding battle of the 23-year-long First Punic War.

The Battle of Cape Ecnomus or Eknomos was a naval battle, fought off southern Sicily, in 256 BC, between the fleets of Carthage and the Roman Republic, during the First Punic War. The Carthaginian fleet was commanded by Hanno and Hamilcar; the Roman fleet jointly by the consuls for the year, Marcus Atilius Regulus and Lucius Manlius Vulso Longus. It resulted in a clear victory for the Romans.
Near the site of the first battle and great Carthaginian defeat of 480 BC, the Second Battle of Himera was fought near the city of Himera in Sicily in 409 between the Carthaginian forces under Hannibal Mago and the Ionian Greeks of Himera aided by an army and a fleet from Syracuse. Hannibal, acting under the instructions of the Carthaginian senate, had previously sacked and destroyed the city of Selinus after the Battle of Selinus in 409. Hannibal then destroyed Himera which was never rebuilt.

The Siege of Lilybaeum lasted for nine years, from 250 to 241 BC, as the Roman army laid siege to the Carthaginian-held Sicilian city of Lilybaeum during the First Punic War. Rome and Carthage had been at war since 264 BC, fighting mostly on the island of Sicily or in the waters around it, and the Romans were slowly pushing the Carthaginians back. By 250 BC, the Carthaginians held only the cities of Lilybaeum and Drepana; these were well-fortified and situated on the west coast, where they could be supplied and reinforced by sea without the Romans being able to use their superior army to interfere.

The Norman conquest of southern Italy lasted from 999 to 1139, involving many battles and independent conquerors. In 1130, the territories in southern Italy united as the Kingdom of Sicily, which included the island of Sicily, the southern third of the Italian Peninsula, the archipelago of Malta, and parts of North Africa.

The naval Battle of Palermo took place on 2 June 1676 during the Franco-Dutch War, between a French force sent to support a revolt in the city of Messina against the Spanish rule in Sicily, and a Spanish force supported by a Dutch maritime expedition force.

The Sicilian Regiment was a light infantry regiment recruited from Sicily that served with the British Army during the Napoleonic wars, from 1806 to its disbandment in 1816.

The Sicilian Expedition was an Athenian military expedition to Sicily, which took place from 415–413 BC during the Peloponnesian War between the Athenian empire, or the Delian League, on one side and Sparta, Syracuse and Corinth on the other. The expedition ended in a devastating defeat for the Athenian forces, severely impacting Athens.

The Sicilian Wars, or Greco-Punic Wars, were a series of conflicts fought between Ancient Carthage and the Greek city-states led by Syracuse, Sicily, over control of Sicily and the western Mediterranean between 580–265 BC.

The Allied invasion of Sicily, codenamed Operation Husky, was a major campaign of World War II, in which the Allies took the island of Sicily from the Axis powers. It began with a large amphibious and airborne operation, followed by a six-week land campaign, and initiated the Italian Campaign.

The Battle of Thermae was a field engagement during the First Punic War that took place in 259 BC near Thermae on the northern coast of Sicily. The Carthaginian general Hamilcar surprised and defeated 6,000 allied troops of Rome.

The Battle of Tyndaris was a naval battle of the First Punic War that took place off Tyndaris in 257 BC. Tyndaris was a Sicilian town founded as a Greek colony in 396 BC located on the high ground overlooking the Tyrrhenian Sea in the Gulf of Patti. Hiero II, the tyrant of Syracuse, allowed Tyndaris to become a base for the Carthaginians. The battle took place in the waters between Tyndaris and the Aeolian Islands, with Gaius Atilius Regulus in command of the Roman fleet. Subsequently, the town fell to Rome.

The War of the Sicilian Vespers or just War of the Vespers was a conflict that started with the insurrection of the Sicilian Vespers against Charles of Anjou in 1282 and ended in 1302 with the Peace of Caltabellotta. It was fought in Sicily, Catalonia and elsewhere in the western Mediterranean between the kings of Aragon on one side against the Angevin Charles of Anjou, his son Charles II, the kings of France, and the Papacy on the other side. The war resulted in the division of the old Kingdom of Sicily; at Caltabellotta, Charles II was confirmed as king of Sicily's peninsular territories, while Frederick III was confirmed as king of the island territories.