
The Siege of Acre was the first significant counterattack by King Guy of Jerusalem against Saladin, leader of the Muslims in Syria and Egypt. This pivotal siege formed part of what later became known as the Third Crusade. The siege lasted from August 1189 until July 1191, in which time the city's coastal position meant the attacking Latin force were unable to fully invest the city and Saladin was unable to fully relieve it with both sides receiving supplies and resources by sea. Finally, it was a key victory for the Crusaders and a serious setback for Saladin's ambition to destroy the Crusader States.

The Siege of Acre took place in 1291 and resulted in the Crusaders losing control of Acre to the Mamluks. It is considered one of the most important battles of the period. Although the crusading movement continued for several more centuries, the capture of the city marked the end of further crusades to the Levant. When Acre fell, the Crusaders lost their last major stronghold of the Crusader Kingdom of Jerusalem. They still maintained a fortress at the northern city of Tartus, engaged in some coastal raids, and attempted an incursion from the tiny island of Ruad, but when they lost that as well in 1302 in the Siege of Ruad, the Crusaders no longer controlled any part of the Holy Land.

The Siege of Ascalon took place in 1153, resulting in the capture of that Egyptian fortress by the Crusader Kingdom of Jerusalem.

The Siege of Burriana was one of the battles that occurred during the Conquest of Valencia by James I of Aragon. Burriana was an important Muslim city, being the capital of La Plana, Valencia. It was known as the "Green City". The city was besieged for two months, finally falling to the forces of James I in July 1233.

The Siege of Damascus took place between 24 and 28 July 1148, during the Second Crusade. It ended in a decisive crusader defeat and led to the disintegration of the crusade. The two main Christian forces that marched to the Holy Land in response to Pope Eugene III and Bernard of Clairvaux's call for the Second Crusade were led by Louis VII of France and Conrad III of Germany. Both faced disastrous marches across Anatolia in the months that followed, with most of their armies being destroyed. The original focus of the crusade was Edessa (Urfa), but in Jerusalem, the preferred target of King Baldwin III and the Knights Templar was Damascus. At the Council of Acre, magnates from France, Germany, and the Kingdom of Jerusalem decided to divert the crusade to Damascus.

The Siege of Al-Dāmūs was a battle of the Reconquista that occurred in the year 1210. The forces of the Kingdom of Aragon, together with auxiliary forces of the Knights Templar and Knights Hospitaller, were pitted against the defending forces of the Almohades. The Christian forces defeated the Muslim defenders. This battle was significant because in taking the castle at Ademuz, the Christian forces riled their Muslim opponents to initiate a grand offensive that would eventually culminate in the Battle of Las Navas de Tolosa. This offensive, in turn, marked the end of the Islamic domination of the region and the beginning of Christian rule in the province.

The Crusader fortress of Krak des Chevaliers fell to the Mamluk sultan Baibars in 1271. Baibars went north to deal with Krak des Chevaliers after the death of Louis IX of France on 29 November 1270.

The Great Siege of Malta took place in 1565 when the Ottoman Empire attempted to invade the island of Malta, then held by the Knights Hospitaller. The Knights, with approximately 2,000 footsoldiers and 400 Maltese men, women, and children, withstood the siege and repelled the invaders. This victory became one of the most celebrated events of sixteenth-century Europe, to the point that Voltaire said: "Nothing is better known than the siege of Malta." It undoubtedly contributed to the eventual erosion of the European perception of Ottoman invincibility, although the Mediterranean continued to be contested between Christian coalitions and the Turks for many years.

The Siege of Rhodes was a military engagement involving the Knights Hospitaller and Mamluk Sultanate. The Mamluk fleet landed on the island of Rhodes on 10 August 1444, besieging its citadel. Clashes took place on the western walls of the city and at the Mandraki harbor. On 18 September 1444, the Mamluks departed from the island and lifted the siege.

In 1480 the small Knights Hospitaller garrison of Rhodes withstood an attack of the Ottoman Empire.

The Siege of Rhodes of 1522 was the second and ultimately successful attempt by the Ottoman Empire to expel the Knights of Rhodes from their island stronghold and thereby secure Ottoman control of the Eastern Mediterranean. The first siege in 1480 had been unsuccessful.

The Fall of Ruad in 1302 was one of the culminating events of the Crusades in the Eastern Mediterranean. When the garrison on the tiny Isle of Ruad fell, it marked the loss of the last Crusader outpost on the coast of the Levant. In 1291, the Crusaders had lost their main power base at the coastal city of Acre, and the Muslim Mamluks had been systematically destroying any remaining Crusader ports and fortresses since then, forcing the Crusaders to relocate their dwindling Kingdom of Jerusalem to the island of Cyprus. In 1299–1300, the Cypriots sought to retake the Syrian port city of Tortosa, by setting up a staging area on Ruad, two miles (3 km) off the coast of Tortosa. The plans were to coordinate an offensive between the forces of the Crusaders, and those of the Ilkhanate. However, though the Crusaders successfully established a bridgehead on the island, the Mongols did not arrive, and the Crusaders were forced to withdraw the bulk of their forces to Cyprus. The Knights Templar set up a permanent garrison on the island in 1300, but the Mamluks besieged and captured Ruad in 1302. With the loss of the island, the Crusaders lost their last foothold in the Holy Land. Attempts at other Crusades continued for centuries, but the Europeans were never again able to occupy any territory in the Holy Land until the 20th century, during the events of World War I.

The Siege of Smyrna was fought between the Knights of Rhodes, who held the harbour and sea-castle of Smyrna in western Anatolia, and the army of the Turco-Mongol emir Timur. The Turco-Mongols blockaded the harbour and attacked the fortifications with stone-throwing siege engines, while the defenders, numbering only about 200 knights, countered with arrows and incendiary projectiles. After two weeks of strong resistance against a far superior adversary, the outer wall was destroyed by mining and breached. Some of the garrison managed to escape by sea, but the inhabitants and the city itself were destroyed.

The Fall of Tripoli was the capture and destruction of the Crusader state, the County of Tripoli, by the Muslim Mamluks. The battle occurred in 1289 and was an important event in the Crusades, as it marked the capture of one of the few remaining major possessions of the Crusaders. The event is represented in a rare surviving illustration from a now fragmentary manuscript known as the 'Cocharelli Codex', thought to have been created in Genoa in the 1330s. The image shows the countess dowager Sibylla of Armenia and Barthélémy Mansel, Bishop of Tortosa sitting in state in the centre of the fortified city, and Qalawun's assault in 1289, with his army depicted massacring the inhabitants fleeing to boats in the harbour and to the nearby island of St Thomas.

The siege of Tripoli occurred in 1551 when the Ottomans besieged and vanquished the Knights of Malta in the fortress of Tripoli, modern Libya. The Spanish had established a fort in Tripoli in 1510, and Charles V remitted it to the Knights in 1530. The siege culminated in a six-day bombardment and the surrender of the city on 15 August.